Heparitin Sulfate (Heparan Sulfate)

01/01/2008 - "This strategy of targeting heparan sulfate may be particularly effective for attacking cancers like myeloma where extensive genetic chaos renders them unlikely to respond well to agents that target a single signaling pathway."
11/08/2005 - "In the current study, we further examined the residues in NKp46 that may be involved in heparan sulfate binding on tumor cells. "
01/22/2002 - "In the present study, the importance of sequence information contained within tumor cell-surface heparan sulfate was investigated. "
11/02/2015 - "Tissue-specificity of heparan sulfate biosynthetic machinery in cancer."
09/01/2015 - "Myeloid precursor cells secreted all the APRIL they produced, and binding of secreted APRIL to MM cells, strictly dependent of heparan sulfate carried by CD138, resulted in an in situ internalization by tumor cells. "

09/15/2015 - "Butanolysis derivatization: improved sensitivity in LC-MS/MS quantitation of heparan sulfate in urine from mucopolysaccharidosis patients."
04/01/2012 - "Our previous studies in mucopolysaccharidosis type IIIB (MPSIIIB), a disease in which a genetic defect induces the accumulation of undigested heparan sulfate (HS) fragments, led to the hypothesis that abnormal lysosome formation was related to events occurring at the Golgi level. "
09/15/2015 - "Heparan sulfate (HS) is a complex oligosaccharide that is a marker of a number of diseases, most notably several of the mucopolysaccharidoses (MPS). "
02/27/2015 - "Heparan sulfate saccharides modify focal adhesions: implication in mucopolysaccharidosis neuropathophysiology."
09/01/2014 - "Novel heparan sulfate assay by using automated high-throughput mass spectrometry: Application to monitoring and screening for mucopolysaccharidoses."

03/05/2010 - "Unique extracellular matrix heparan sulfate from the bivalve Nodipecten nodosus (Linnaeus, 1758) safely inhibits arterial thrombosis after photochemically induced endothelial lesion."
01/01/1991 - "A heparan sulfate-related preparation (suleparoide) was much less effective in both thrombosis models, especially in the venous one, while the activity was most specifically directed to the maintenance of endothelial stability."
04/24/2012 - "Both heparin and heparan sulfate are known to be potent inhibitors of thrombosis. "
06/01/2004 - "We propose that the main biological role of PF4 and the basis for its presence in the alpha granules of all known mammalian platelets is to neutralize surface heparan sulfate side-chains of glycosaminoglycans and to optimize thrombus development at sites of vascular injury. "
04/18/2003 - "The unusually severe thrombosis associated with the heterozygous mutation may be explained by the ability of antithrombin London to bind endogenous heparan sulfate or heparin molecules with high affinity and to thereby block activation of the normal inhibitor."

01/01/2010 - "A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis."
01/01/2010 - "We applied a loss-of-function genetic approach employing lymphatic endothelial conditional mutations in heparan sulfate biosynthesis to study the effects on tumor-lymphatic trafficking and lymph node metastasis. "
09/13/2012 - "The heparan sulfate 6-O-endosulfatase (SULF2) promotes growth and metastasis of solid tumors. "
08/01/2011 - "Epac1 promotes melanoma metastasis via modification of heparan sulfate."
01/01/2011 - "M402, a novel heparan sulfate mimetic, targets multiple pathways implicated in tumor progression and metastasis."

12/01/2014 - "Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2), an enzyme mediating 3-O-sulfation of heparan sulfate (HS), is silenced by hypermethylation in breast cancer. "
01/01/2007 - "A heparan sulfate-targeted conditionally replicative adenovirus, Ad5.pk7-Delta24, for the treatment of advanced breast cancer."
11/01/2005 - "Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer."
01/01/2013 - "In addition to HER2 levels, heparan sulfate synthesis and shedding determine breast cancer cell susceptibility to trastuzumab."
01/01/2013 - "Trastuzumab action is dependent on the availability of heparan sulfate on the surface of breast cancer cells. "