Heparinoids (Heparinoid)

Heparin derivatives. The term has also been used more loosely to include naturally occurring and synthetic highly-sulphated polysaccharides of similar structure. Heparinoid preparations have been used for a wide range of applications including as anticoagulants and anti-inflammatories and they have been claimed to have hypolipidemic properties. (From Martindale, The Extra Pharmacopoeia, 30th, p232)

Also Known As:

Networked: 322 relevant articles (23 outcomes, 45 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Burroughs, A K: 4 articles (02/2009 - 02/2005)
2.	Burroughs, Andrew K: 3 articles (06/2014 - 10/2002)
3.	Senzolo, M: 3 articles (02/2009 - 04/2007)
4.	Riddell, A: 3 articles (02/2008 - 02/2005)
5.	Sandercock, P: 3 articles (01/2005 - 01/2000)
6.	Counsell, C: 3 articles (01/2005 - 01/2000)
7.	Hill, Michael D: 2 articles (03/2015 - 01/2012)
8.	Triantos, Christos: 2 articles (06/2014 - 01/2009)
9.	Riddell, Anne: 2 articles (06/2014 - 02/2009)
10.	Thalheimer, Ulrich: 2 articles (06/2014 - 01/2009)

Related Diseases

1.	Stroke (Strokes) 09/01/1993 - "Low molecular weight heparinoids (LMWHs) offer a new treatment option to patients experiencing acute ischemic stroke. " 01/01/2001 - "PC patients did not show any particular benefit from anticoagulation, and the efficacy of heparinoid did not vary between AC and PC stroke. " 07/01/2000 - "Low-molecular-weight heparins and heparinoids in acute ischemic stroke : a meta-analysis of randomized controlled trials." 11/01/1988 - "Recent advances in noninvasive diagnostic techniques to detect DVT early and the development of relatively safe heparinoid compounds increase the need for a prophylactic study in patients with ischemic stroke." 12/01/2001 - "However, an i.v. low-molecular-weight heparinoid showed a trend toward improving long-term outcome in subgroup of patients with atherothrombotic stroke. "
2.	Venous Thrombosis (Deep-Vein Thrombosis) 01/23/1992 - "The incidence of deep-vein thrombosis was 56.6% and 15.5% respectively in the placebo and heparinoid treated patients (incidence reduction: 74%; P less than 0.001). " 01/23/1992 - "Prevention of deep vein thrombosis following total hip replacement by low molecular weight heparinoid." 04/22/1998 - "Low molecular weight heparins and heparinoids have been shown to be effective in preventing deep vein thrombosis in persons with stroke, and they might be effective in reducing unfavorable outcomes following ischemic stroke. " 04/01/2003 - "Based on study results, most reviews and therapy recommendations for the treatment of acute stroke generally decline the use of high-dose heparins and heparinoids with full anticoagulation for improving outcome or preventing secondary embolic events as well as low-dose applications for venous thrombosis prophylaxis. " 01/01/2005 - "Allocation a to low-molecular-weight heparin or heparinoid was associated with a significant reduction in the odds of deep vein thrombosis (Peto odds ratio 0.52, 95% confidence interval 0.56 to 0.79). "
3.	Thrombocytopenia (Thrombopenia) 03/02/1992 - "In no case was there an exacerbation of the thrombocytopenia nor thromboembolic complications while on heparinoid therapy. " 04/01/1991 - "This is the first report of thrombocytopenia caused by heparinoid. " 03/01/1995 - "[Successful therapy of heparin-associated thrombocytopenia with a low sulfated heparinoid]." 01/01/1992 - "[Heparin-associated thrombocytopenia: successful therapy of patients after prospective selection of a compatible heparinoid with the heparin-induced platelet activation test]." 01/01/2006 - "Of those, heparinoid has been shown to be safer and more effective for the prevention of postoperative VTE than UFH, especially for treatment of heparin-induced thrombocytopenia (HIT). "
4.	Pain (Aches) 06/23/2008 - "Non-steroidal-anti-inflammatory drugs or local treatment with heparinoid may reduce the pain. " 10/01/1993 - "We found significant differences between the two treatments with TNG yielding greater improvement in terms of disappearance of pain (TNG: 50.2 +/- 39.7, heparinoids: 72.0 +/- 39.9), time for reducing erythema in half (TNG: 28.0 +/- 24.2, heparinoids: 54.6 +/- 34.5), and time for reducing fibrous cord in half (TNG: 58.3 +/- 38.4, heparinoids: 84.5 +/- 41.5). " 01/01/1989 - "Treatment with the surfactant sodium pentosanpolysulphate, a heparinoid, given orally to patients with chronic prostatitis reduced concomitant pain in muscles and joints. " 01/01/2015 - " array of topical treatments, such as heparinoid or diclofenac gels, improved pain compared to placebo or no intervention. " 01/01/2008 - "In head-to-head studies comparing different topical heparin formulations, all preparations appeared effective but heparin gel 1000 IU/g was superior to a heparinoid mucopolysaccharide cream (Hirudoid) in patients with vascular disorders in terms of resolving spontaneous pain, induced pain, oedema and heaviness in the limb. "
5.	Phlebitis 10/01/1993 - "We conclude that transcutaneous TNG should be applied systematically in patients with superficial phlebitis, given that it is more effective than the usual treatment with heparinoid substances." 05/01/1969 - "[Considerations on the prevention and treatment of superficial phlebitis in anesthesiological practice, using a semisynthetic heparinoid]." 10/01/1993 - "The purpose of this study was to evaluate the beneficial effects of transdermal nitroglycerine (TNG) in the treatment of superficial phlebitis caused by endovenous catheters and to compare them with the effects from the application of heparinoid substances. " 01/01/2003 - "The actual time of disappearance of the signs and symptoms of phlebitis also were significantly shorter in patients treated with notoginseny cream than with heparinoid cream." 10/01/1993 - "[Heparinoids versus nitroglycerin in the treatment of superficial phlebitis]."

Related Drugs and Biologics

1.	Heparin (Liquaemin)
2.	danaproid (danaparoid)
3.	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)
4.	Factor Xa (Coagulation Factor Xa)
5.	Sodium
6.	Hirudoid
7.	fondaparinux (Arixtra)
8.	Ointments (Pastes)
9.	Semaphorin-3A
10.	Tacrolimus (Prograf)

Related Therapies and Procedures

1.	Catheters
2.	Hip Replacement Arthroplasty (Total Hip Replacement)
3.	Rhinoplasty
4.	Phototherapy (Light Therapy)
5.	Compression Stockings