Hempa (Hexamethylphosphoramide)

A chemosterilant agent that is anticipated to be a carcinogen.

Also Known As:

Hexamethylphosphoramide; HMPA; Hexamethylphosphoric Triamide; Triamide, Hexamethylphosphoric; Hexametapol; Phosphoric triamide, hexamethyl-

Networked: 25 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Phosphoramides: 8
    - Hempa: 25
      - thiohempa

Experts

1.	Hamada, Junichi: 2 articles (03/2015 - 02/2012)
2.	Iizuka, Takahiro: 2 articles (03/2015 - 02/2012)
3.	Sakai, Fumihiko: 2 articles (03/2015 - 02/2012)
4.	Sato, Mayumi: 2 articles (03/2015 - 02/2012)
5.	Chen, Shuang: 1 article (01/2021)
6.	Choi, Garam: 1 article (01/2021)
7.	Choi, Sang Ho: 1 article (01/2021)
8.	Gao, Wenqing: 1 article (01/2021)
9.	Im, Hanhyeok: 1 article (01/2021)
10.	Kim, Dukyun: 1 article (01/2021)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2020 - "This study hypothesized that there is an association between chronic stress (as indexed by resting amygdalar activity [AmygA]), hematopoietic system activity (HMPA), and subclinical cardiovascular indexes (aortic vascular inflammation [VI] and noncalcified coronary plaque burden [NCB]) in psoriasis (PSO). " 01/01/1982 - "Rats exposed by inhalation to hexamethylphosphoramide (HMPA) at concentrations of 50, 100, 400, and 4000 parts per billion (ppb) for 6-24 months revealed nasal tumors and squamous metaplasia with inflammation in the nasal epithelium, but no changes were observed at 10 ppb. "
2.	Epilepsy (Aura) 02/01/2012 - "The authors performed serial neuroimaging studies during acute stage and after recovery of aura symptoms in eight HMPA attacks in two affected individuals of the Japanese family of FHM during a 10-year-observational period. " 03/01/2015 - "We evaluated CBF at different phases of aura symptoms in 11 attacks of HMPA. " 03/01/2015 - "We assessed neurovascular changes with time in the affected cerebral hemisphere corresponding to aura symptoms during the acute phase of HMPA. " 03/01/2015 - "To report biphasic changes in cerebral blood flow (CBF) in the acute phase of hemiplegic migraine with prolonged aura (HMPA), in which aura symptoms lasted longer than 24 h, in three patients with familial hemiplegic migraine (FHM) carrying a p.H916L mutation in ATP1A2 gene. "
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2020 - "This study hypothesized that there is an association between chronic stress (as indexed by resting amygdalar activity [AmygA]), hematopoietic system activity (HMPA), and subclinical cardiovascular indexes (aortic vascular inflammation [VI] and noncalcified coronary plaque burden [NCB]) in psoriasis (PSO). " 01/01/2020 - "Furthermore, a consecutive subset of 30 patients with severe PSO (Psoriasis Area Severity Index Score >10) were followed at 1 year to assess the relationship between skin disease improvement and AmygA, HMPA, VI, and NCB. "
4.	Chromosome Aberrations (Chromosome Abnormalities) 09/01/2012 - "Chromosome aberration frequency in rat peripheral lymphocytes increases with repeated dosing with hexamethylphosphoramide or cyclophosphamide." 09/01/2012 - "Therefore, in the current study, after optimising culture conditions for rat lymphocytes in this laboratory, rats were given oral doses of cyclophosphamide or hexamethylphosphoramide (HMPA) for up to 28 days and peripheral lymphocytes analysed for chromosome aberrations at various time points. "
5.	Adenocarcinoma 01/01/2012 - "The aim of this study therefore was to analyze the impact of synchronous liver-directed therapy on operative outcome and overall survival in patients with hepatic metastasized pancreatic adenocarcinoma (HMPA). " 01/01/2012 - "22 patients who underwent simultaneous pancreas resection and liver-directed therapy for HMPA between January 1, 2004 and January 1, 2009 were compared to 22 patients who underwent classic pancreas resection for nonmetastasized pancreatic adenocarcinoma (NMPA) in a matched pair study design. "

Related Drugs and Biologics

1.	Hempa (Hexamethylphosphoramide)
2.	Cyclophosphamide (Cytoxan)
3.	N- methyl- N- 2- (methylsulfinyl)ethylpropionic acid amide (NMPA)
4.	Volatile Fatty Acids
5.	Dihydrotachysterol (AT 10)
6.	A-Form DNA (A-DNA)
7.	Cyclins
8.	Altretamine (Hemel)
9.	Formaldehyde (Formol)
10.	Doxorubicin (Adriamycin)

Related Therapies and Procedures

1.	Therapeutics
2.	Transjugular Intrahepatic Portasystemic Shunt