Hemothorax

10/01/2019 - "Study Selection and Data Extraction: Articles were included if they described the use of intrapleural alteplase in adult patients with a retained hemothorax; single patient case reports and abstracts were excluded. "
10/01/2021 - "We used the techniques in a benchtop model with tissue plasminogen activator (tPA) and pig hemothorax with tPA. "
01/01/2021 - "Effectiveness of Delayed Intrapleural Alteplase Instillation for Infected Residual Traumatic Hemothorax. "
10/01/2019 - "Conclusion: Administration of intrapleural alteplase should be considered in patients with retained hemothorax as an alternative to surgical intervention. "
10/01/2019 - "Relevance to Patient Care and Clinical Practice: Because of the paucity of data for use of alteplase in retained hemothorax and administration of a high-risk medication, this review provides dosing and administration recommendations based on reported safety and efficacy. "

09/01/2015 - "VATS versus intrapleural streptokinase: A prospective, randomized, controlled clinical trial for optimum treatment of post-traumatic Residual Hemothorax."
07/01/2011 - "Massive hemothorax following administration of intrapleural streptokinase."
04/01/2009 - "Intrapleural streptokinase treatment for postoperative coagulated hemothorax in a newborn."
04/01/2005 - "We conclude that intrapleural streptokinase increases resolution of clot in the pleural space and decreases pleural thickening and adhesion in experimental minimal clotted hemothorax in ewes. "
04/01/2005 - "Use of intrapleural streptokinase in experimental minimal clotted hemothorax."

06/01/2022 - "Following the first dose of DNase and tPA, the patient developed hypoxemia with hypotension and was found to have rapid development of white-out right hemothorax."
02/20/2022 - "This study evaluated the effectiveness of intrapleural tissue plasminogen activator (tPA) with and without DNase in the treatment of retained traumatic hemothorax. "
04/01/2017 - "Various studies have documented success in using fibrinolytics such as tissue plasminogen activator (tPA) in conjunction with deoxyribonuclease administered through a chest tube to resolve a hemothorax. "
06/01/2022 - "Hemothorax With White-Out Lung After Intrapleural Tissue Plasminogen Activator and Deoxyribonuclease Therapy in a Patient With Complicated Parapneumonic Effusion."
02/20/2022 - "Dornase alfa (DNase) has demonstrated efficacy in parapneumonic effusion, but the lack of deoxyribonucleoproteins limits direct extrapolation to traumatic retained hemothorax treatment. "

02/01/1989 - "Tube drainage of the pleural cavity was performed in 10 patients who had hemothorax or hemopneumothorax, and antibiotics were administered to all patients. "
04/01/2012 - "Following an intensive and specific antibiotic therapy and with an almost completed recovery of the renal function, he underwent surgical management, consisting in the evacuation and drainage of the hemothorax, followed by resection of the aneurysm and extensive tissular debridmente, culminating in the vascular reconstruction utilizing the "simplified technique", introduced in 1984 by A. "
06/01/1996 - "We enrolled patients with hemothorax or empyema, clotted and/or loculated, that was not resolved through conventional pleural drainage with chest tube and antibiotics in patients with empyema. "
12/01/1986 - "We conducted a prospective randomized study of patients requiring tube thoracostomy for pneumo- and/or hemothorax complicating blunt or penetrating thoracic trauma in an attempt to assess the efficacy of prophylactic antibiotic therapy. "
06/01/1997 - "Factors predictive of development of empyema were retained hemothorax (odds ratio, 12.5; 95% confidence interval, 0.96-163), pulmonary contusion (odds ratio, 6.3; 95% confidence interval, 1.53-25.8), and multiple chest tube placement (odds ratio, 2.5; 95% confidence interval, 1.91-3.28); factors not predictive of empyema were severity of injury, mechanism of injury, setting in which TT was performed, number of days chest tubes were in place, and antibiotic drugs at the time of TT. "

01/01/2012 - "Herein, a case with localized pleural plaques and spontaneous hemothorax due to warfarin treatment which was improved with medical treatment is presented because of its rarity. "
01/01/2013 - "To our knowledge, massive hemothorax due to warfarin use is an extremely rare condition."
01/01/2013 - "Nontraumatic massive spontaneous hemothorax with concomitant warfarin use."
01/01/2002 - "[Hemothorax with high number of eosinophils following warfarin overdose]."
05/09/2021 - "Spontaneous, Loculated, and Massive Hemothorax: An Uncommon Complication of Warfarin Therapy."

02/01/1994 - "A three day old male, term infant with hemothorax due to hemorrhagic disease of the newborn was treated successfully with vitamin K and thoracocentesis. "
02/01/1994 - "Exclusive breast feeding and absence of vitamin K prophylaxis were important diagnostic clues, although hemothorax as a sole manifestation of hemorrhagic disease of the newborn is rare. "
10/01/2007 - "Hemothorax as presentation of late vitamin-K-deficient bleeding in a 1-month-old infant with homozygous alpha-1-antitrypsin deficiency."
01/01/1991 - "Hemorrhagic cardiomyopathy and hemothorax in vitamin K deficient mice."
09/01/2021 - "Although direct-acting oral anticoagulants (DOACs) decrease the bleeding risk compared with vitamin K antagonists (VKAs), DOACs might cause spontaneous hemothorax in very elderly patients, even at a very low dose. "

05/01/2016 - "Intrapleural fibrinolytic agents should be considered a useful therapeutic option for the treatment of postoperative residual hemothorax. "
07/01/1998 - "The use of intrapleural fibrinolytic agents has resulted in resolution of clotted hemothorax with an overall success rate of 91.7%. "
05/01/1994 - "Intrapleural instillation of thrombolytic agents has been useful in the treatment of hemothorax when thoracostomy tube drainage is unsuccessful. "

09/01/2006 - "Hemothorax in a nonhemophilic patient can be successfully treated with rFVIIa."
09/01/2006 - "Successful treatment of intractable hemothorax with recombinant factor VIIa in a nonhemophilic patient."
09/01/1998 - "[Successful treatment of hemothorax with recombinant factor VIIa in a hemophilic child with inhibitor]."
09/01/2006 - "We report a case of catastrophic hemothorax in which bleeding was stopped by administration of rFVIIa. "
01/01/2006 - "The subsequent development of hemothorax in the present case indicates that a more protracted course of recombinant FVIIa is justified following pericardiocentesis for pericardial bleeding in hemophilia with inhibitors. "

02/20/2022 - "Dornase alfa added to tPA may not reduce the need for operation to treat retained hemothorax. "
02/20/2022 - "Retrospective Evaluation of Intrapleural Tissue Plasminogen Activator With or Without Dornase Alfa for the Treatment of Traumatic Retained Hemothorax: A 6-Year Experience."
04/01/2017 - "Tissue plasminogen activator and pulmozyme for postoperative-retained hemothorax: A safe alternative to postoperative re-exploration."
02/20/2022 - "Dornase alfa (DNase) has demonstrated efficacy in parapneumonic effusion, but the lack of deoxyribonucleoproteins limits direct extrapolation to traumatic retained hemothorax treatment. "

02/20/2022 - "Dornase alfa (DNase) has demonstrated efficacy in parapneumonic effusion, but the lack of deoxyribonucleoproteins limits direct extrapolation to traumatic retained hemothorax treatment. "

01/01/2023 - "Open versus percutaneous tube thoracostomy with and without thoracic lavage for traumatic hemothorax: a novel randomized controlled simulation trial."
03/01/1997 - "Altogether, 26 of the 240 study patients had hemothorax, as confirmed by tube thoracostomy or CT. "
09/01/2023 - "To our knowledge, no prior cases have been reported immediately following thoracostomy tube placement and hemothorax drainage in the ED setting. "
01/01/2023 - "Treatment of traumatic hemothorax (HTX) with open tube thoracostomy (TT) is painful and retained HTX is common. "
11/01/2022 - "Irrigation of the thoracic cavity at tube thoracostomy (TT) placement may decrease the rate of a retained hemothorax (RHTX); however, other resource utilization outcomes have not yet been quantified. "

01/01/2021 - "Efficacy of a novel chest tube system in a swine model of hemothorax."
06/22/2020 - "Previous studies have provided initial data suggesting that small-bore (SB, ≤ 14Fr) chest tubes have the same efficacy as large-bore (LB, > 14 Fr) chest tubes for acute hemothorax (HTX), but data continue to be lacking in the setting of delayed HTX. "
04/01/2015 - "The autologous transfusion of the patient's shed blood collected through chest tubes for hemothorax was found to be safe without complications in this study. "
10/01/2014 - "Our study aimed to analyze the relationship between radiological chest tube parameters (position and intrathoracic length) and the frequency of residual hemothorax. "
09/01/2023 - "We present the case of a 46-year-old female who presented to the emergency department (ED) for delayed left-sided hemothorax (six weeks following a high-speed motor vehicle collision) and developed an acute SCM following large-bore chest tube placement. "

09/01/2022 - "However, an initial approach with TPA lytic therapy may be preferred for retained traumatic hemothorax to lower the total cost of admission given its high probability of avoiding the operating room with its resultant increased costs. "
01/01/2020 - "If medical therapy and early procedures fail to resolve the retained hemothorax, surgery is usually indicated. "
01/01/2020 - "The most promising therapy consists of fibrinolytics which are infused into the pleural space, disrupting the hemothorax, allowing for further drainage. "
01/01/2019 - "Lytic Therapy for Retained Traumatic Hemothorax: A Systematic Review and Meta-analysis."
06/01/2006 - "Examination of both effusions confirmed the diagnosis of spontaneous bilateral hemothorax due to combined anti-platelet therapy. "

10/22/2020 - "We performed repetitive video-assisted thoracoscopic surgery (VATS) for the debridement and hemostasis; however, hemothorax was uncontrollable. "
10/01/2012 - "Computed tomography on the 27th postoperative day revealed mediastinitis and right hemothorax; open debridement and evacuation were performed. "
05/01/1991 - "Enzymatic debridement of the pleural cavity for retained hemothorax or empyema is a frequently overlooked option. "
09/01/1998 - "We conclude that early OVT in the military field hospital for continued bleeding, clotted hemothorax, and continued major air leakage has several advantages in military patients with PFAWT: early definition and management of organ injury; identification and control of bleeding in most instances; earlier and more accurate assessment for thoracotomy; vigorous lavage and removal of projectiles such as bone fragments and evacuation of clotted hemothorax; early debridement with suture closure of the thoracic wall canal; and minimal postoperative pain with dramatically reduced suppurative sequelae and bronchopleural fistulae."
06/01/2002 - "Operative procedures included fibrinopurulent empyema with debridement and decortication in 15 children, biopsy and(or) resection of mediastinal tumor in 11, bullectomy and cystectomy of the lung in 6, lobectomy with huge cyst of the lung or sequestration in 5, clearance of hemothorax in 2, and exploration, and repair of diaphragmatic hernia in 2. RESULTS The mean operative time was 74 minutes (range 30 to 220 minutes). "

12/01/2021 - "However, for patients requiring thoracotomy for retained hemothorax, concomitant SSRF was associated with improved survival (HR = 0.14, 95% CI 0.06-0.32, P < .001). "
01/01/2022 - "Few studies have identified factors associated with successful VATS or thoracotomy as the initial operative strategy among patients with traumatic hemothorax. "
01/01/2023 - "One patient had experienced a pleura injury and hemothorax and had required urgent thoracotomy. "
12/14/2022 - "Complete VATS is safe and feasible for re-operation due to post-operative hemothorax and can be an alternative to thoracotomy. "
10/23/2022 - "Based on our results and the literature, we can safely state that the use of thoracoscopy in the treatment of hemothorax is a safe and reliable option in eligible patients, and the results are comparable with those treated by thoracotomy. "