Hemosiderosis

Conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the MONONUCLEAR PHAGOCYTE SYSTEM, without demonstrable tissue damage. The name refers to the presence of stainable iron in the tissue in the form of hemosiderin.

Also Known As:

Networked: 398 relevant articles (14 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Seizures (Seizure)
2.	Iron Overload
3.	Anemia
4.	Fibrosis (Cirrhosis)
5.	Liver Cirrhosis (Hepatic Cirrhosis)

Experts

1.	Vichinsky, Elliott: 4 articles (09/2013 - 01/2005)
2.	Cappellini, Maria Domenica: 3 articles (04/2010 - 07/2006)
3.	Neufeld, Ellis J: 3 articles (01/2010 - 10/2008)
4.	Liang, R: 3 articles (10/2009 - 12/2007)
5.	Tam, S: 3 articles (10/2009 - 12/2007)
6.	Forni, Gian Luca: 3 articles (04/2008 - 07/2006)
7.	Chu, Winnie C W: 2 articles (01/2014 - 11/2012)
8.	Cabantchik, Z Ioav: 2 articles (01/2014 - 06/2005)
9.	Paley, Carole: 2 articles (09/2013 - 11/2009)
10.	Chirnomas, Deborah: 2 articles (09/2013 - 11/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemosiderosis:

1.	IronIBA 09/01/2008 - "Hepatic hemosiderosis along with serum iron markers improved greatly in the representative patient. " 09/01/1991 - "Methods for evaluating iron stores and efficacy of chelation in transfusional hemosiderosis." 04/28/1984 - "In contrast, joint involvement did not correlate with parameters of iron metabolism or severity of hemosiderosis of other organs, and was not relieved by phlebotomy. " 01/01/2014 - "Thus, to the extent that apoptosis can be considered a biological indicator of damage, the etiopathology of cardiosiderotic damage that accompanies some forms of hemosiderosis would seem to be unrelated to LTCC or TTCC, but rather to other routes of iron ingress present in heart cells." 05/01/2013 - "Hemosiderosis develops secondary to increased iron absorption, as well as transfusion burden. "
2.	Deferoxamine (Desferal)FDA LinkGeneric 07/01/1982 - "Ours are the first published results of a preliminary short-term trial of combined therapy with deferoxamine and hemofiltration in a dialysis patient with hemosiderosis. " 05/01/2007 - "Since 1962, desferrioxamine (deferoxamine, DFO) has been utilized for the treatment of secondary hemosiderosis. " 07/01/1987 - "[Subcutaneous administration of deferoxamine in a patient with panmyelopathy and post-transfusion hemosiderosis]." 11/02/1984 - "[Deferoxamine in hemosiderosis. " 11/02/1984 - "[Therapy of hemosiderosis with deferoxamine]."
3.	deferasiroxFDA Link 01/01/2013 - "Deferasirox, when given in doses ≥30 mg/kg, was found to be an effective and safe drug in reducing transfusional hemosiderosis. " 07/01/2006 - "In a phase II study, the tolerability and efficacy of deferasirox were compared with those of DFO in 71 adults with transfusional hemosiderosis. " 04/01/2008 - "The effect of food and time of food intake on the pharmacokinetics of deferasirox was investigated in healthy volunteers and patients with transfusional hemosiderosis. " 05/01/2007 - "Deferasirox (DSX) is a recently developed oral chelator which shows good efficacy and tolerability in patients with transfusional hemosiderosis due to various underlying disorders. " 03/15/2007 - "In 2005, the Food and Drug Administration approved the labeling for deferasirox for the treatment of chronic overload due to transfusional hemosiderosis. "
4.	Ferritins (Ferritin)IBA 01/01/2013 - "Our results show a significant reduction of ferritin levels and improvement of liver hemosiderosis, assessed by means of magnetic resonance imaging T2* (MRI T2*). " 10/01/2009 - "Despite abnormal ferritin and liver T2*, only 5% of patients had cardiac hemosiderosis. " 01/01/2005 - "According to the last 5 years' mean serum ferritin level, pts were divided into three hemosiderosis groups: (1) mild (<2000 microg/L) 49%, (2) moderate (2000-4000 microg/L) 28%, and (3) severe (>4000 microg/L) 23%. " 12/01/2007 - "We performed a study of magnetic resonance imaging (MRI) assessment of hemosiderosis in the heart (T2/T2*), liver (T2*), pancreas (T2*), and pituitary gland (T2/T2*/SIR) in 20 hemopoietic stem cell transplant (HSCT) recipients (median peak ferritin levels 7615 pmol/L, range 3411 to 33000 pmol/L). " 02/01/2011 - "In patients with AA, more than 200 PRBC units transfused were required to induce cardiac hemosiderosis, in spite of chelation therapy and, in one patient, of normal ferritin values."
5.	ErythropoietinFDA Link 01/01/1991 - "Successful treatment of hemosiderosis with regular phlebotomy and recombinant human erythropoietin. " 05/01/1992 - "Two hemodialysis patients with hemosiderosis were treated with combined erythropoietin and repeated phlebotomy. " 01/01/1993 - "Management of hemosiderosis complicated by coexistent anemia with recombinant human erythropoietin and phlebotomy." 01/01/1988 - "Treatment of a seven-year-old child with end-stage renal disease and hemosiderosis by recombinant human erythropoietin." 01/01/1991 - "A 55-year-old female patient with hemosiderosis induced by administration of excessive doses of parenteral iron was successfully treated with regular phlebotomy combined with recombinant human erythropoietin (rHuEPO). "
6.	Adrenal Cortex Hormones (Corticosteroids)IBA 03/01/2008 - "[Superficial hemosiderosis of the central nervous system improved by corticosteroids]." 08/01/1984 - "Allogeneic bone marrow transplantation (BMT) was carried out on a 5-year-old boy with congenital hypoplastic anemia (CHA), who did not respond to corticosteroids and who was displaying signs of progressive hemosiderosis. "
7.	lipoarabinomannan (LAM)IBA 09/01/2008 - "A case of severe liver cirrhosis with hepatic hemosiderosis that was treated successfully with LAM also is shown as a representative case. " 01/01/2008 - "LAM cell proliferation may obstruct bronchioles, lymph vessels and venules that lead to airflow obstruction, formation of lung cysts, bullas and pneumothoraces, chylothorax, chylous ascites, hemosiderosis and hemoptysis. "
8.	Transferrin (beta 2 Transferrin)IBA 03/01/2008 - "The purpose of the present study was to determine the distribution of iron and of transferrin in the eyes and lacrimal glands of rats in experimental hemosiderosis, so as to achieve a better understanding of the formation of the ocular lesions observed in patients with advanced hemosiderosis. " 01/01/1985 - "Of the 2 noninvasive diagnostic tests the serum ferritin level was more reliable than percent saturation of transferrin in predicting the histological diagnosis of hemosiderosis. " 11/01/2002 - "The main findings are fetal growth retardation, Fanconi type aminoaciduria, cholestasis, iron overload (liver hemosiderosis, hyperferritinemia, hypotransferrinemia, increased transferrin iron saturation, and free plasma iron), profound lactic acidosis, and early death. " 07/01/2008 - "This study suggests that ferritin, serum iron concentration, and percent transferrin saturation are convenient, noninvasive, antemortem methods for assessing severity of hemosiderosis in callitrichids." 07/01/2008 - "This study evaluated the relationship between hematologic iron analyte values (iron, ferritin, total iron binding capacity, and percent transferrin saturation) and hepatic hemosiderosis in callitrichids at the Wildlife Conservation Society's Central Park and Bronx Zoos. "
9.	HemosiderinIBA 10/01/2015 - "MR signal changes were not only conclusive with subarachnoid hemosiderin depositions but in many cases also resembled those that have been associated with cortical hemosiderosis. " 12/01/2005 - "Interestingly, autopsy disclosed moderate hemosiderin deposits in the liver, the organ usually involved in hemosiderosis." 01/01/1987 - "Of a degree of hemosiderosis one could judge on the basis of a histochemical investigation of tissue hemosiderin only. " 01/01/1980 - "Experimental hemosiderosis: relationship between skin pigmentation and hemosiderin." 02/01/2015 - "Reports of kidney biopsy findings in patients with hemolysis-related kidney injury have focused primarily on the accumulation of hemosiderin pigment within proximal tubular epithelial cells (hemosiderosis), a feature of chronic hemolysis. "
10.	Familial apoceruloplasmin deficiencyIBA 05/01/1995 - "Hereditary ceruloplasmin deficiency with hemosiderosis: a clinicopathological study of a Japanese family." 02/01/1999 - "We report a 49-year-old female with hereditary ceruloplasmin deficiency with hemosiderosis. " 02/01/1999 - "[A case of hereditary ceruloplasmin deficiency with hemosiderosis]." 02/01/1998 - "[Cerebral hemosiderosis related to hereditary ceruloplasmin deficiency. " 06/01/1996 - "Hereditary ceruloplasmin deficiency with hemosiderosis."

Therapies and Procedures

1.	Hemispherectomy 02/01/1993 - "None has developed superficial cerebral hemosiderosis often seen following the classical anatomical hemispherectomy. " 09/01/1992 - "It was replaced by the subtotal hemispherectomy which effectively eliminated the late complication of superficial cerebral hemosiderosis but was less successful in controlling seizures. " 04/01/2006 - "The efficacy of anatomical hemispherectomy has been offset to some degree by the fact that up to one third of those operated upon will subsequently develop obstructive hydrocephalus, and the so-called superficial subpial cerebral hemosiderosis, with potentially fatal complications. " 10/01/2000 - "In particular, anatomical hemispherectomy is blamed to be associated with a higher incidence of surgical complications, namely hydrocephalus and hemosiderosis, than other less ablative operations such as functional hemispherectomies. " 05/01/1983 - "Preserving the frontal and occipital poles but disconnecting them from the rest of the brain, resulting in a functional complete but anatomical subtotal hemispherectomy, retains the therapeutic effectiveness of a complete hemispherectomy while still protecting adequately against the serious late postoperative complication of superficial cerebral hemosiderosis and its associated neurologic deterioration, hydrocephalus and sometimes death."
2.	Renal Dialysis (Hemodialysis) 08/01/1984 - "This study suggests that one should be careful in making an early diagnosis of hepatic disease, especially hemosiderosis, in hemodialysis patients based on the hepatic CT absorption value because it is affected by hemodialysis." 07/17/1981 - "Hemosiderosis in hemodialysis patients." 07/25/1980 - "Hemosiderosis in hemodialysis patients. " 05/01/1980 - "Hepatic hemosiderosis in maintenance hemodialysis (MHD) patients." 01/01/1988 - "There have been some reports on the risk of developing hemosiderosis in hemodialysis patients when heavily transfused and simultaneously possessing hemochromatosis alleles (HA). "
3.	Blood Transfusion (Blood Transfusions) 06/01/2012 - "A few other features seen in MPDs are caused by extramedullary hematopoiesis, increased hepatic blood flow, and secondary hemosiderosis from multiple blood transfusions. " 10/01/1997 - "In spite of a little amount of blood transfusion, he showed hepatic hemosiderosis. " 04/13/1996 - "Repeat blood transfusions may produce clinically overt organ hemosiderosis, e.g. " 04/01/1986 - "Hemosiderosis of the liver is chiefly seen in homozygous beta-thalassaemia patients who have been kept alive with repeated blood transfusions. " 01/01/1956 - "[Hemosiderosis caused by blood transfusion]."
4.	Chelation Therapy (Therapy, Chelation) 08/01/2014 - "Chelation therapy is necessary to prevent the consequences of hemosiderosis. " 04/01/1965 - "[New possibilities in chelation therapy for hemosiderosis]." 10/01/2005 - "Although the indications for transfusions in sickle cell syndromes are well listed, and chronic transfusion has become practicable since the recent advances in chelation therapy have essentially eliminated the risk of secondary iron overload, multi-transfused, non-compliant to long-term chelation therapy patients confront the complication of iron overload and secondary hemosiderosis. " 12/01/2013 - "The imaging of pediatric hemoglobinopathies, which is influenced by concomitant hemosiderosis and the sequela of chelation therapy, has evolved over the years along with ever-improving technology. " 10/01/2005 - "Transfusional hemosiderosis and combined chelation therapy in sickle thalassemia."
5.	Transplantation (Transplant Recipients) 01/01/1986 - "This study describes the ultrastructural features of hemosiderosis occurring in five transplant recipients. " 01/23/2015 - "The medications that transplant recipients need to take can impair liver function, and transfusionassociated hemosiderosis can do so as well. " 11/27/1995 - "Successful transplantation of kidneys with hemosiderosis." 05/01/1992 - "This is the first case report of complete resolution of hemosiderosis as documented histologically by liver biopsies in a cadaveric renal transplant recipient." 05/01/1992 - "A 33-year-old cadaveric renal transplant recipient showed complete histologic resolution of hemosiderosis by liver biopsies obtained pre- and post-transplantation. "