Hemorrhagic Disorders (Hemorrhagic Diathesis)

Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).

Also Known As:

Networked: 489 relevant articles (7 outcomes, 15 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Eczema
3.	Hemophilia A (Haemophilia)
4.	Hemorrhage
5.	Neoplasms (Cancer)

Experts

1.	Franchini, Massimo: 7 articles (10/2014 - 04/2007)
2.	Lippi, Giuseppe: 4 articles (01/2011 - 04/2007)
3.	Zawilska, Krystyna: 2 articles (07/2013 - 01/2008)
4.	Pinotti, M: 2 articles (09/2012 - 06/2006)
5.	Bernardi, F: 2 articles (09/2012 - 06/2006)
6.	Ferraresi, P: 2 articles (09/2012 - 06/2006)
7.	Manzato, Franco: 2 articles (06/2008 - 04/2007)
8.	Peyvandi, Flora: 2 articles (11/2005 - 08/2002)
9.	Norman, Keith E: 2 articles (08/2004 - 05/2004)
10.	Li, Rui: 1 article (12/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemorrhagic Disorders:

1.	Tranexamic Acid (AMCA)FDA Link 07/01/2013 - "Tranexamic acid, non-steroidal anti-inflammatory drugs and high dose of oestrogen may be useful in the management of acute hemorrhagic disorders. " 12/01/2011 - "Tranexamic acid, non-steroidal anti-inflammatory drugs and high dose of oestrogen may be useful in the management of acute hemorrhagic disorders. " 08/01/2007 - "Although off-pump coronary artery bypass surgery is associated with reduced frequency of hemorrhagic disorders, defective hemostasis still occurs, and tranexamic acid effectively reduces postoperative blood loss and the need for allogeneic blood products." 11/01/2005 - "To control the hemorrhagic diathesis, we commenced combination therapy for DIC with danaparoid (1,250 Ux2/day, intravenously (IV)) and tranexamic acid (0.5 g x 3/day, peros (PO). "
2.	recombinant FVIIa (rFVIIa)IBA 06/01/2008 - "In this retrospective study, rFVIIa was found to be effective at controlling severe hemorrhagic symptoms of different etiologies in children without congenital hemorrhagic disorder. " 06/01/2008 - "In this retrospective study, the records of the patients who were not diagnosed with congenital hemorrhagic disorder and were administered rFVIIa due to any other reason in Ege University Faculty of Medicine, Department of Pediatrics, between February 2002 and February 2007 were reviewed retrospectively. " 06/01/2008 - "Single-center experience: use of recombinant factor VIIa for acute life-threatening bleeding in children without congenital hemorrhagic disorder." 04/01/2015 - "The aim of this study was to present our experience in preventing bleeding and hemorrhagic disorders in surgical patients with inherited FVII deficiency by using recombinant activated FVIIa (rFVIIa), and with prothrombin complex concentrates (PCCs). " 04/01/2008 - "It is postulated that, in vivo, both the TF-dependent and TF-independent thrombin generation induced by rFVIIa contribute to the control of hemorrhage in patients with platelet-related bleeding disorders and, perhaps, other causes of hemorrhagic diatheses."
3.	Carbon MonoxideIBA 01/01/2012 - "The use of CO(2) lasers is currently the gold standard in the excision of this type of lesion, especially in patients with hemorrhagic diathesis or under antithrombotic therapy." 01/01/2008 - "Hemorrhagic diathesis, co-morbidity, number of blood transfusions, and subsequent management were also noted. "
4.	Phenobarbital (Luminal)FDA Link 07/09/1956 - "[Vasoparalytic hemorrhagic diathesis cured by luminal sleep]."
5.	ankaferd blood stopperIBA 01/01/2010 - "To determine the efficacy of the topical application of Ankaferd Blood Stopper (ABS) on hemorrhagic diathesis following dental procedures under different conditions. "
6.	Fibrinogen (Factor I)FDA Link 08/01/2005 - "The results indicated that soluble FM-fibrinogen complex appears to be a useful diagnostic molecular marker to assess the activity of the coagulation system, and that its preoperative level may serve as a potential risk factor for intraoperative hemorrhagic diathesis in patients undergoing elective AAA repair." 10/01/1984 - "An abnormal fibrinogen was discovered in a 9-year-old male subject without history of hemorrhagic diathesis. " 01/01/1980 - "Therefore, proteolytic changes of fibrinogen do not play a role for inducing a hemorrhagic disorder after sublethal X-ray irradiation in rabbits." 11/15/1975 - "Proceedings: A new congenital dysfibrinogenemia with hemorrhagic diathesis (fibrinogen Montreal II)." 10/01/1970 - "[Observations on the fibrinogen consumption rate in thrombotic and hemorrhagic disorders]."
7.	Factor XIII (Coagulation Factor XIII)IBA 05/31/1970 - "Congenital hemorrhagic diathesis with deficiency of factor XIII. A case report and a family study." 11/01/2014 - "Factor XIII (FXIII) deficiency is a rare hemorrhagic disorder for which the highest incidence occurs in southeast Iran. " 01/15/2009 - "Acquired factor XIII (FXIII) deficiency due to autoantibody against FXIII is a very rare severe hemorrhagic diathesis. " 05/01/2007 - "Congenital factor XIII (FXIII) deficiency is a rare congenital hemorrhagic disorder. " 02/01/2006 - "A 1967 report described the first known case of congenital factor XIII (FXIII) deficiency in the United States in a male patient with a severe hemorrhagic disorder. "
8.	FibrinIBA 10/23/1965 - "[Coagulation disorders without hemorrhagic diathesis due to delayed aggregration of fibrin molecules]." 10/06/1962 - "[Generalized hemorrhagic diathesis and vascular fibrin precipitations in the secondary stages of experimental fat embolism]." 12/01/1980 - "[Fibrin sealing: a new method for dressing tooth extraction wounds in patients with an increased hemorrhagic diathesis]." 10/01/1999 - "Congenital factor XIII deficiency is a rare hemorrhagic syndrome with an altered fibrin stability, hemorrhagic diathesis and habitual abortions. " 11/01/1998 - "Fibrinogen Caracas I: a dysfibrinogenemia with a hemorrhagic diathesis associated with diminished fibrin fiber diameter and reduced fibrin gel porosity."
9.	Vitamin KFDA Link 11/01/1946 - "Hemorrhagic Diathesis Experimentally Induced by Deficiency in Vitamin K: A Histopathologic Study." 07/01/1960 - "Hemorrhagic diathesis during pregnancy due to unexplained lack of vitamin K. " 01/01/1992 - "The adverse outcomes range from dysmorphic features to hemorrhagic disorders resulting from a deficiency of vitamin K-dependent clotting factors or to spina bifida. " 01/01/1992 - "Vitamin K deficient hemorrhagic diathesis is well known as a cause of infantile intracranial hemorrhage. " 11/01/1977 - "A 15-year-old boy with Henoch-Schönlein purpura experienced a major hemorrhagic diathesis that was responsive to parenterally administered vitamin K. "
10.	von Willebrand FactorIBA 05/01/2005 - "Characterization of a myeloma patient with a life-threatening hemorrhagic diathesis: presence of a lambda dimer protein inhibiting shear-induced platelet aggregation by binding to the A1 domain of von Willebrand factor." 01/01/2013 - "Von Willebrand disease (VWD) is an inherited hemorrhagic disorder promoted by either quantitative or qualitative defects of the von Willebrand factor (VWF). " 06/22/2002 - "[From gene to disease; from mutations in the Von Willebrand factor gene to hemorrhagic diathesis and thrombocytopenia]." 12/01/1993 - "Synergistic effect of storage pool deficient platelets and low plasma von Willebrand factor on the severity of the hemorrhagic diathesis in Hermansky-Pudlak syndrome." 10/01/2014 - "Acquired hemophilia A is a truly exceptional hemorrhagic diathesis, that consists of the emergence of polyclonal autoantibodies (inhibitor) IgG-type (subclasses 1 and 4, in most cases) against the coagulant function of the circulating factor VIII, which acts in the domains C2, A2 and A3 of the molecule, thus interfering their interaction with the factor IXa, the phospholipids and the Von Willebrand factor. "

Therapies and Procedures

1.	Lasers (Laser) 01/01/2012 - "The use of CO(2) lasers is currently the gold standard in the excision of this type of lesion, especially in patients with hemorrhagic diathesis or under antithrombotic therapy."
2.	Aftercare (After-Treatment) 11/11/2010 - "After treatment, the patients' clinical condition markedly improved, with resolution of hemorrhagic diathesis, eczema, autoimmunity, and predisposition to severe infection. "
3.	Blood Transfusion (Blood Transfusions) 12/01/1962 - "[Studies on the mechanism of hemorrhagic diathesis after the massive blood transfusion]." 10/01/2008 - "A 41-year-old-woman presented with hemorrhagic diathesis needed blood transfusions occasionally during her life-time. " 04/17/1960 - "[Application of blood transfusion in hemorrhagic diathesis]." 09/17/1955 - "Hemorrhagic disorder following massive whole blood transfusions." 12/07/1951 - "[On the value of blood transfusion in the thrombopenic hemorrhagic diatheses]."
4.	Intravenous Injections 04/01/1999 - "Immunohistochemical study showed that the intravenous injection of the purified factor to sarcoma 180-bearing mouse resulted in hemorrhagic disorder all over the tissue in the tumor lamp. "
5.	Splenectomy 03/05/1989 - "Owing to the ineffective therapies and increasing hemorrhagic diathesis splenectomy was performed under perioperative Venagamma protection without success. " 01/01/1985 - "Splenectomy entailed a considerable decrease in hemorrhagic diathesis. " 10/01/1956 - "[Hemorrhagic diathesis after splenectomy (hemorrhagic thrombocythemia)]." 06/01/1990 - "Increasing thrombocytosis was observed immediately after splenectomy, and hemorrhagic diathesis of nasal bleeding and gastrointestinal bleeding were also detected. " 06/01/1967 - "[Change in the function of adrenal glands during splenectomy in patients with hemorrhagic diathesis at different methods of use of steroid hormones]."