Hemoptysis

Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.

Also Known As:

Networked: 1199 relevant articles (54 outcomes, 27 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Dyspnea (Shortness of Breath)
2.	Cough
3.	Neoplasms (Cancer)
4.	Pain (Aches)
5.	Hemorrhage

Experts

1.	Shiraishi, Yuji: 4 articles (08/2014 - 07/2011)
2.	Ernst, Armin: 4 articles (09/2012 - 11/2008)
3.	Parrot, Antoine: 4 articles (01/2012 - 10/2003)
4.	Langer, Corey J: 4 articles (05/2010 - 09/2007)
5.	Koh, Won-Jung: 3 articles (01/2015 - 06/2008)
6.	Zaric, Bojan: 3 articles (10/2014 - 10/2012)
7.	Dutau, Hervé: 3 articles (10/2014 - 09/2004)
8.	Zarogoulidis, Paul: 3 articles (10/2014 - 01/2013)
9.	Huang, Haidong: 3 articles (10/2014 - 01/2013)
10.	Li, Qiang: 3 articles (10/2014 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemoptysis:

1.	Prednisone (Sone)FDA LinkGeneric 06/01/2001 - "Prednisone administration could control the disease, but every attempt to lower the dose to less than 25 mg per day was followed by recurrence of hemoptysis. " 04/01/1989 - "Complete resolution of hemoptysis and radiologic signs of pulmonary artery aneurysms was observed three months after prednisone treatment, and a persisting remission was noted after ten months. " 01/01/2007 - "Fatal massive hemoptysis in a patient on low-dose oral prednisone: chronic necrotizing pulmonary aspergillosis." 01/01/2013 - "Methyl-prednisolone pulses followed by prednisone led to cessation of hemoptysis, marked improvement of lung fuction, and normal finding on chest x-ray within 10 days. " 04/01/2007 - "After treatment with prednisone, oral cyclophosphamide and plasmapheresis, chest X-ray and hemoptysis improved, but renal failure persisted. "
2.	Amphotericin B (Amphotericin)FDA LinkGeneric 10/01/1993 - "Our results suggest that percutaneous intracavitary instillation of amphotericin B is a safe and effective method of treating hemoptysis caused by aspergillomas." 05/01/2013 - "We retrospectively reviewed all patients hospitalized at our institution for hemoptysis associated with an aspergilloma over an 8-year period and who underwent percutaneous intracavitary instillation of amphotericin B (ICAB). " 05/01/2013 - "A modern series of percutaneous intracavitary instillation of amphotericin B for the treatment of severe hemoptysis from pulmonary aspergilloma." 03/01/2013 - "The patient was administered amphotericin B, but succumbed to massive hemoptysis. " 05/01/1998 - "He was administrated intravenous and oral anti-fungal agent and transbronchial installation of Amphotericin-B because of hemoptysis. "
3.	Hemoglobins (Hemoglobin)IBA 08/01/2013 - "On a multivariate analysis, factors independently associated with improved survival were higher hemoglobin values (hazard ratio [HR], 0.78; 95% CI, 0.67-0.91) and cessation of hemoptysis without recurrence at 48 hours (HR, 0.43; 95% CI, 0.22-0.84). " 02/01/2013 - "Hemoptysis (75%), drop in hemoglobin (74%), and chest infiltrates (94%) were the most common clinical findings. " 06/01/2004 - "The mean drop in hemoglobin was 3.2 +/-1.1 g/dL, hemoptysis occurred in 50%, the Dlco was increased in 10 of 11 patients (91%), and 11 of 14 patients who underwent bronchoscopy had positive findings. " 07/01/2014 - "Clinical features of DAH include dyspnea, a drop in hemoglobin, and diffuse radiographic alveolar images, with or without hemoptysis. " 11/01/2003 - "Age>50 years, hypertension, hemoglobin on admission<10 g/dl, cause of hemoptysis, and a prior attack of hemoptysis were the predictors for the need of emergency surgery. "
4.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/01/2012 - "Steroid therapy combined with cyclophosphamide was started; however, hemoptysis was not resolved until plasmapheresis therapy was added. " 01/01/1975 - "Cyclophosphamide was employed in the third patient with systemic vasculitis and massive hemoptysis. " 07/01/2008 - "A 74-year-old woman with a history of type I cryoglobulinemia with glomerulonephritis that had been successfully treated with plasmapheresis and cyclophosphamide approximately 9 years earlier presented with hemoptysis and mediastinal lymphadenopathy. " 03/01/2015 - "The patient was treated with a combination of high-dose steroids and pulse cyclophosphamide, but he died from massive hemoptysis. " 05/01/2001 - "Treatment with plasmapheresis, pulse methylprednisolone and pulse cyclophosphamide effectively improved his hemoptysis as well as chest X-ray findings and blood gas analysis. "
5.	ThrombinFDA Link 07/01/2002 - "Treatment of massive hemoptysis with intraarterial thrombin injection of a bronchial artery." 04/18/1956 - "[Local treatment of tuberculous hemoptysis by thrombase]." 03/01/1982 - "[Thrombin instillation therapy through the fiberoptic bronchoscope in cases of hemoptysis (author's transl)]." 07/01/2003 - "In these cases, the efficacy of fibrinogen-thrombin (FT) instilled endoscopically as treatment for massive hemoptysis was assessed. " 01/01/2013 - "The fibrinogen-thrombin could be considered as a bridge, transitory measure for massive hemoptysis, while definitive treatment could be established."
6.	AntibodiesIBA 02/01/2004 - "We conclude that there was an association between the presence of Aspergillus antibodies and hemoptysis in patients with old tuberculosis or bronchiectasis, suggesting that these patients probably had occult infections caused by the corresponding fungi. " 02/01/2004 - "A 17-month prospective study was carried out to compare the prevalence of Aspergillus fumigatus and Aspergillus flavus antibodies in hemoptysis patients with old tuberculosis or bronchiectasis but no radiologically visible mycetoma (cases, n = 38), hemoptysis patients with other diagnosis (control group 1, n = 29), and patients with old tuberculosis or bronchiectasis but no hemoptysis (control group 2, n = 47) by a recently developed sensitive and specific A. " 02/01/2004 - "Association of presence of Aspergillus antibodies with hemoptysis in patients with old tuberculosis or bronchiectasis but no radiologically visible mycetoma." 02/01/2004 - "Development of serological tests against other Aspergillus species as well as other causes of mycetoma will probably increase the detection of occult mold infections in patients with existing parenchymal lung diseases, and treatment of fungal microinvasion may help to alleviate hemoptysis in these patients with bronchiectasis or old tuberculosis who have Aspergillus antibodies." 04/01/2007 - "Despite negative anti-GBM antibodies, he was treated similarly to a relapse and after the second course of plasmapheresis the patients' general condition improved and hemoptysis subsided. "
7.	Fibrinogen (Factor I)FDA Link 07/01/2003 - "In these cases, the efficacy of fibrinogen-thrombin (FT) instilled endoscopically as treatment for massive hemoptysis was assessed. " 01/01/2013 - "The fibrinogen-thrombin could be considered as a bridge, transitory measure for massive hemoptysis, while definitive treatment could be established." 01/01/2013 - "[Fibrinogen-thrombin as bridge therapy in massive hemoptysis]." 07/01/2003 - "Use of endoscopic fibrinogen-thrombin in the treatment of severe hemoptysis." 09/01/1989 - "Massive hemoptysis was present in ten patients receiving thrombin therapy and nine patients receiving fibrinogen-thrombin therapy. "
8.	MethylprednisoloneFDA LinkGeneric 01/01/2014 - "Treatment with methylprednisolone was continued, and the patient gradually stopped coughing and had no expectoration and hemoptysis. " 05/01/1984 - "In both patients, pulmonary infiltrations and hemoptysis had already resolved after the first pulse methylprednisolone dose (1000 mg IV). " 06/01/2010 - "He was treated with 1 g of intravenous methylprednisolone over 3 days with rapid improvement in hemoptysis and hypoxemia. " 05/01/2001 - "Treatment with plasmapheresis, pulse methylprednisolone and pulse cyclophosphamide effectively improved his hemoptysis as well as chest X-ray findings and blood gas analysis. "
9.	micafungin (FK463)FDA Link 08/01/2009 - "A 23-year old woman with acute biphenotypic leukemia (ABL) complained of chest pain with cough, high fever and hemoptysis during induction chemotherapy, although she had been treated with anti-biotics and micafungin. " 01/01/2007 - "However, intravenous administration of micafungin (MCFG) and oral itraconazole improved clinical data and symptoms, although he later died of massive hemoptysis. " 12/01/2005 - "Despite immediate treatment with intravenous micafungin and oral itraconazole and improved brief initial improvement, his general condition abruptly deteriorated into frequent massive hemoptysis and he developed of shock, respiratory failure, and severe malnutrition, dying 30 days later. "
10.	Itraconazole (Sporanox)FDA LinkGeneric 01/01/2007 - "However, intravenous administration of micafungin (MCFG) and oral itraconazole improved clinical data and symptoms, although he later died of massive hemoptysis. " 12/01/2005 - "Despite immediate treatment with intravenous micafungin and oral itraconazole and improved brief initial improvement, his general condition abruptly deteriorated into frequent massive hemoptysis and he developed of shock, respiratory failure, and severe malnutrition, dying 30 days later. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2012 - "After induction of chemotherapy, hemoptysis stopped and her constitutional symptoms improved. " 08/01/2014 - "The indications for surgery include a poor response to drug therapy, the development of macrolide-resistant disease, or the presence of a significant disease-related complication such as hemoptysis. " 07/01/2014 - "He presented at our emergency unit within 4 years of completion of the chemotherapy, with sudden massive hemoptysis. " 09/01/2013 - "Hemoptysis due to breath-hold diving following chemotherapy and lung irradiation: a differential diagnosis; with authors' reply." 08/01/2012 - "Hemoptysis due to breath-hold diving following chemotherapy and lung irradiation."
2.	Aftercare (After-Treatment) 05/01/2013 - "In these 20 episodes, hemoptysis ceased by hospital discharge in 17 of 20 patients (85%) and in all 18 who survived until a follow-up visit 1-month after treatment. " 08/01/2012 - "3 cases with mild hemoptysis turned better after treatment. " 06/01/1999 - "He therefore underwent a pulmonary resection including the lesion due to the continued hemoptysis that did not improve even after treatment by hemostatic agents and bronchial arterial embolization. " 01/01/1999 - "Fatal hemoptysis (FH) occurred in 12 patients; 10 of these within 6 months after treatment. " 05/01/1997 - "One patient with local control died from hemoptysis 12 months after treatment. "
3.	Bronchoscopes 11/01/2012 - "Age range, sex, hemoptysis, smoking, CXR, and bronchoscope finding were not significant different between pulmonary TB and not pulmonary TB. " 11/01/2000 - "Utilizing a blind method to locate the bronchial cuff of a left-sided DLT without using any instrument, a DLT (Broncho-Cath, Mallinckrodt Medical Ltd., Athlone, Ireland) was successfully positioned without delay in a patient with massive hemoptysis, where auscultation could be misleading or useless and fiberoptic bronchoscope (FOB) was inapplicable. " 09/01/1989 - "We conclude that infusion therapy using a fiberoptic bronchoscope is a simple and effective low-risk technique of choice for the treatment of hemoptysis patients." 03/01/1988 - "The importance of taking a meticulous history and the use of computed tomography in the localization of the lesion are emphasized, and the use of the fiberoptic bronchoscope in peripheral lesions and in the investigation of hemoptysis is discussed." 05/01/1985 - "Clinical diagnosis of massive hemoptysis using the fiberoptic bronchoscope."
4.	Radiotherapy 01/01/2015 - "After radiotherapy, general status improved and the hemoptysis resolved in all patients. " 01/01/2015 - "There are only 9 cases with a short follow-up that have reported the use of radiotherapy for hemoptysis in this scenario. " 01/01/2013 - "To discuss the application of external beam radiotherapy (EBRT) and technetium-99m-labeled red blood cell scintigraphy (LRBCS) in life-threatening hemoptysis from a non-malignant condition. " 10/01/2011 - "Treatment of hemoptysis associated with aspergilloma using external beam radiotherapy: A case report and literature review." 01/01/2002 - "One patient had significant recurrent hemoptysis that was managed with radiotherapy. "
5.	Catheters 12/01/1978 - "This case documents that recurrent massive hemoptysis can be successfully controlled with repeated use of this procedure and that the simultaneous placement of more than one catheter can be safe and effective therapy that is well tolerated by patients." 09/01/2014 - "In patients who develop massive or recurrent hemoptysis after Swan-Ganz catheter use, PA injury must be considered and airway protection should be employed along with appropriate catheter based or surgical interventions." 09/01/2014 - "Cause of death in 22% of the cases was hemoptysis, while non-catheter related complications were responsible for the remaining deaths. " 09/01/2014 - "Fifty-one percent of the patients had an episode of hemoptysis on the day of Swan-Ganz catheter insertion. " 11/08/2013 - "The imaging modalities available for the diagnostic evaluation of hemoptysis include chest radiography, multi-detector computed tomography (MDCT), magnetic resonance imaging (MRI) and catheter angiography. "