Hemoperfusion

Removal of toxins or metabolites from the circulation by the passing of blood, within a suitable extracorporeal circuit, over semipermeable microcapsules containing adsorbents (e.g., activated charcoal) or enzymes, other enzyme preparations (e.g., gel-entrapped microsomes, membrane-free enzymes bound to artificial carriers), or other adsorbents (e.g., various resins, albumin-conjugated agarose).

Also Known As:

Networked: 1723 relevant articles (178 outcomes, 180 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Ronco, Claudio: 22 articles (12/2022 - 01/2007)
2.	Nakamura, Tsukasa: 13 articles (12/2011 - 05/2002)
3.	Koide, Hikaru: 12 articles (09/2011 - 05/2002)
4.	Sakamoto, Yuichiro: 10 articles (11/2020 - 11/2006)
5.	Obata, Toru: 10 articles (01/2018 - 03/2006)
6.	Mitaka, Chieko: 9 articles (01/2022 - 11/2009)
7.	Antonelli, Massimo: 9 articles (06/2021 - 06/2009)
8.	Miki, Takahiro: 9 articles (01/2014 - 01/2005)
9.	Kawagoe, Yasuhiro: 9 articles (12/2011 - 01/2003)
10.	Matsumoto, Hisashi: 8 articles (01/2017 - 11/2006)

Related Diseases

1.	Poisoning 12/01/2021 - "The efficacy of hemoperfusion (HP) treatment for PQ poisoning remains controversial. " 05/01/2012 - "In this case study, the poisoned patient's clinical condition and laboratory values improved gradually after she received hemoperfusion (HP) and plasma exchange, which indicated that the therapy with HP and plasma exchange were helpful in the treatment of 1,2,3-TCP poisoning." 04/01/2000 - "We describe a case of 2 adults with confirmed Amanita phalloides poisoning treated with hemodialysis (HD) immediately after arrival at our tertiary care hospital (23 h after ingestion) and later with hemoperfusion (HP); a series blood samples were taken to determine the clearance of the toxin by each method. " 01/01/1982 - "Prediction of the efficacy of hemoperfusion and hemodialysis in severe poisoning." 01/01/2017 - "This study assessed the effects of hemoperfusion (HP) and continuous renal replacement therapy (CRRT) on the survival of PQ-poisoned patients with plasma PQ levels below 5,000ng/mL. We analyzed the records of 164 patients with PQ poisoning who were treated at the First Affiliated Hospital of Wenzhou Medical University in China between January 2011 and May 2015. "
2.	Septic Shock (Toxic Shock Syndrome) 01/01/2023 - "Our observational case series suggests a possible role for HA330 hemoperfusion as an adjunctive treatment of refractory septic shock in children with high severity scores in the context of rapid improvement in organ dysfunction, without serious adverse effects." 10/01/2007 - "Direct hemoperfusion with the PMX-05R column is effective in ameliorating clinical and laboratory abnormalities in elderly septic shock patients." 01/01/2006 - "Direct hemoperfusion (DHP) with polymixin B-immobilized fiber (PMX) has been reported to be effective for patients with septic shock. " 01/01/2023 - "Twelve patients hospitalized in the PICU and diagnosed with septic shock between July 2021 and May 2022 were included in this study and received hemoperfusion with HA330. " 02/01/2020 - " study was to evaluate the clinical effects of hemoperfusion (HP) combined with pulse high volume hemofiltration (PHVHF) on septic shock.Thirty"
3.	Sepsis (Septicemia) 01/01/2018 - "Our own experience with the use of selective hemoperfusion in a fairly large group of cardiovascular patients with sepsis showed the safety and efficacy of these procedures." 11/01/2022 - "The effect of HA330 hemoperfusion adsorbent method on inflammatory markers and end-organ damage levels in sepsis: a retrospective single center study." 01/01/2013 - "This study aimed to observe the effect of hemoperfusion (HP) cartridge on different internal environment indicators at different time points in patients with acute blood poisoning and to find alternative indicators for the detection of blood poisoning. " 09/01/2010 - "[Selective hemoperfusion in gram-negative severe sepsis of patients after cardiac surgery: a prospective randomized study]." 09/01/1978 - "[Use of hemosorption in the treatment of sepsis (an experimental study)]."
4.	Infections 02/15/2002 - "Finally, RT-PCR, SS-PCR, and PERV-specific RT assay detected no PERV infection in the blood samples obtained from five study patients both before and at various times post-hemoperfusion. " 04/08/2023 - "Clinical indicators, including the vasopressor inotropic score and infection markers, should all be considered when deciding whether to begin hemodialysis and hemoperfusion. " 12/01/2014 - "An appreciable part of the structural and functional changes in the liver in patients with HCV and HBV infections was caused by the therapeutic complex, including programmed hemoperfusion." 02/28/2006 - "Finally, RT-PCR detected no PERV infection was found in the blood samples obtained from three patients at various times post-hemoperfusion. " 03/01/1999 - "Medical workers, mental inpatients, hematological patients, patients hospitalized at hemoperfusion departments, and imprisoned subjects were referred to groups at risk of HCV infection: antiHCV were detected in 3.9, 5.4, 13.8, 53.6, and 24.5% of these groups, respectively. "
5.	Shock 01/01/2017 - "However, among the patients in refractory shock with a multiple organ dysfunction score of more than 9 and an EAA between 0.6 and 0.9, a 10.7% reduction in 28-day mortality was recognized (p = 0.0474) when they received two sessions of hemoperfusion using the PMX fiber column. " 01/01/2014 - "Immediate initiation of hemoperfusion treatment with polymixin B immobilized fiber (PMX-DHP) is a potent strategy to improve hemodynamics in septic patients with critical circulatory failure. " 06/01/2011 - "We describe the use of synthesized resin-absorbed hemoperfusion in the therapy of a 48-year-old man who developed carotic, cardiovascular shock and multiorgan dysfunction due to a CBZ overdose (the highest concentration of drug >20 mg/L; therapeutic range, 8-12 mg/L). " 09/01/2007 - "While PMB is known to effectively sequester LPS, its severe systemic toxicity proscribes its parenteral use, and hemoperfusion may not be feasible in patients in shock. " 05/01/1991 - "Use of hemosorption favoured essential reduction of lethality, decrease of the number of severe complications (exotoxic shock, hepatopathy)."

Related Drugs and Biologics

1.	Polymyxin B (Aerosporin)
2.	Charcoal (Charbon)
3.	Paraquat
4.	Endotoxins
5.	Cytokines
6.	Carbamazepine (Tegretol)
7.	Methotrexate (Mexate)
8.	Therapeutic Uses
9.	Polymyxins (Polymyxin)
10.	Bilirubin

Related Therapies and Procedures

1.	Therapeutics
2.	Renal Dialysis (Hemodialysis)
3.	Continuous Renal Replacement Therapy
4.	Plasmapheresis
5.	Drug Therapy (Chemotherapy)