Hemolytic-Uremic Syndrome

A syndrome that is associated with microvascular diseases of the KIDNEY, such as RENAL CORTICAL NECROSIS. It is characterized by hemolytic anemia (ANEMIA, HEMOLYTIC); THROMBOCYTOPENIA; and ACUTE RENAL FAILURE.

Also Known As:

Networked: 1775 relevant articles (34 outcomes, 61 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Thrombotic Thrombocytopenic Purpura
2.	Infection
3.	Diarrhea
4.	Thrombotic Microangiopathies
5.	Neoplasms (Cancer)

Experts

1.	George, James N: 27 articles (05/2015 - 01/2002)
2.	Zipfel, Peter F: 24 articles (05/2014 - 03/2002)
3.	Vesely, Sara K: 21 articles (05/2015 - 01/2003)
4.	Remuzzi, Giuseppe: 21 articles (08/2014 - 08/2002)
5.	Terrell, Deirdra R: 19 articles (05/2015 - 01/2003)
6.	Noris, Marina: 18 articles (07/2014 - 08/2002)
7.	Karch, Helge: 15 articles (10/2015 - 01/2002)
8.	Palermo, Marina S: 13 articles (12/2015 - 10/2002)
9.	Skerka, Christine: 13 articles (03/2014 - 01/2006)
10.	Paton, James C: 12 articles (01/2014 - 04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemolytic-Uremic Syndrome:

1.	thymidine 5'-triphosphate (TTP)IBA 06/01/2015 - "Data from previous publications from the Oklahoma TTP-hemolytic uremic syndrome (HUS) Registry are summarized. " 01/01/2015 - "Of 137 patients, 70 (51%) were determined to have primary (idiopathic) TTP and 67 (49%) secondary TTP or hemolytic uremic syndrome (HUS). " 02/01/2014 - "The experience of the Oklahoma TTP-HUS (hemolytic-uremic syndrome) Registry, a population-based cohort of consecutive patients without selection or referral bias, 1995-2012, was analyzed. " 10/01/2013 - "The incidence rates for TTP in children and adults were calculated from patients enrolled in the Oklahoma TTP-HUS (Hemolytic-Uremic syndrome) Registry, 1996-2012. " 09/19/2013 - "The Oklahoma TTP-HUS (hemolytic uremic syndrome) Registry enrolled 70 consecutive patients from 1995 to 2011 with ADAMTS13 activity <10% at their initial episode; 57 survived, with follow-up through 2012. "
2.	Shiga Toxin (Shigella Toxin)IBA 10/01/2014 - "To screen Hemolytic Uremic Syndrome (HUS) related differentially expressed genes using the microarray data of neonatal microvascular endothelial cells from human skin treated with or without Shiga toxin, and study the the mechanism of HUS from multiple angles. " 08/01/2003 - "1. To study the epidemiological and clinical features of Shiga toxin (Stx)-mediated (post-diarrheal) hemolytic uremic syndrome (HUS) occurring in more than 1 family member. " 01/01/2016 - "CFH gene mutation in a case of Shiga toxin-associated hemolytic uremic syndrome (STEC-HUS)." 12/01/2015 - "Under some circumstances, Shiga toxin (Stx) produced within the intestinal tract enters the bloodstream, leading to systemic complications that may cause the potentially fatal hemolytic-uremic syndrome (HUS). " 09/15/2015 - "Recovery of thalamic microstructural damage after Shiga toxin 2-associated hemolytic-uremic syndrome."
3.	Complement System Proteins (Complement)IBA 09/01/2006 - "Defective complement control resulting in hemolytic uremic syndrome explains the disease mechanism and allows improved diagnosis and therapy. " 11/01/2015 - "Successful therapeutic intervention in treating Complement-mediated diseases such as Hemolytic Uremic Syndrome represent a promising advance to continue the research on Complement to develop specific inhibitors for treating human diseases. " 06/01/2014 - "Role of complement in enterohemorrhagic Escherichia coli-Induced hemolytic uremic syndrome." 01/01/2014 - "Hemolytic uremic syndrome with simultaneous Shiga toxin producing Escherichia coli and complement abnormalities." 05/01/2013 - "Mutations in other complement genes have been associated with C3 glomerulopathy and hemolytic uremic syndrome. "
4.	eculizumabFDA Link 06/01/2015 - "Eculizumab in Typical Hemolytic Uremic Syndrome (HUS) With Neurological Involvement." 04/01/2015 - "Response to Eculizumab in Escherichia coli O157: H7-induced hemolytic uremic syndrome with severe neurological manifestations." 01/15/2015 - "Safe and effective use of eculizumab in the treatment of severe Shiga toxin Escherichia coli-associated hemolytic uremic syndrome." 06/01/2015 - "Two patients enrolled on the Safety and Efficacy Study of Eculizumab in Shiga-Toxin Producing E coli Hemolytic-Uremic Syndrome (STEC-HUS) each received 6 doses of Eculizumab, 3 patients 2 doses, and 6 patients 1 dose. " 01/15/2015 - "A severe case of Shiga toxin Escherichia coli (STEC)-associated hemolytic uremic syndrome (HUS) successfully treated with eculizumab is reported. "
5.	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/01/2012 - "The increase in Stx2-production by ON-2011 following mitomycin C treatment may or may not be related to the high rates of hemolytic uremic syndrome associated with the German outbreak strain. " 06/20/2003 - "[Mitomycin-induced hemolytic-uremic syndrome]." 05/01/2002 - "Mitomycin-C is used widely in the treatment of malignancies and is associated with serious dose related adverse effects including the occurrence of hemolytic uremic syndrome. " 05/01/2002 - "Mitomycin-C induced hemolytic uremic syndrome: a case report." 02/01/2000 - "[Hemolytic-uremic syndrome caused by mitomycin c: long-term management]."
6.	ThrombomodulinIBA 10/01/2013 - "Efficacy of recombinant human soluble thrombomodulin for childhood hemolytic uremic syndrome." 03/01/2013 - "A novel strategy for hemolytic uremic syndrome: successful treatment with thrombomodulin α." 10/01/2003 - "Decrease of thrombomodulin contributes to the procoagulant state of endothelium in hemolytic uremic syndrome." 07/01/2004 - "[Thrombomodulin and thrombophilia in hemolytic uremic syndrome]." 01/01/2001 - "Increased plasma thrombomodulin as a vascular endothelial cell marker in patients with thrombotic thrombocytopenic purpura and hemolytic uremic syndrome."
7.	Complement Factor H (Factor H)IBA 09/01/2003 - "Successful (?) therapy of hemolytic-uremic syndrome with factor H abnormality." 02/01/2001 - "Several recent studies have established an association between abnormalities of complement factor H (FH) and the development of hemolytic uremic syndrome (HUS). " 06/01/2014 - "Complement factor H-antibody-associated hemolytic uremic syndrome: pathogenesis, clinical presentation, and treatment." 05/01/2014 - "Anti-factor H autoantibody-associated hemolytic uremic syndrome: the earlier diagnosed and treated, the better." 04/01/2012 - "[A case of anti-factor H autoantibody-associated hemolytic uremic syndrome]."
8.	Heparin (Liquaemin)FDA LinkGeneric 01/01/1974 - "[Coagulation studies and treatment with heparin in a case of hemolytic-uremic-syndrome (author's transl)]." 04/08/1976 - "Letter: Heparin for the hemolytic uremic syndrome." 09/01/1974 - "Has heparin changed the prognosis of the hemolytic-uremic syndrome." 07/01/1974 - "Letter: Heparin and the hemolytic uremic syndrome." 08/01/1973 - "Heparin therapy in the hemolytic-uremic syndrome."
9.	Epoprostenol (Prostacyclin)FDA LinkGeneric 04/01/1986 - "Plasma from 24 children with hemolytic uremic syndrome (HUS) (10 in acute, 14 in remission phase), 42 first degree relatives and 24 controls were studied for PGI2 supporting activity (PSA) from human umbilical arterial rings and the concentration of PGI2 metabolite (PGI2m). " 08/01/1992 - "Previous studies have reported various abnormalities in prostacyclin (PGI2) synthesis and metabolism in hemolytic-uremic syndrome (HUS). " 01/01/1996 - "[Prostacyclin in the treatment of hemolytic-uremic syndrome: apropos of a case]." 08/01/1992 - "Renal prostacyclin biosynthesis is reduced in children with hemolytic-uremic syndrome in the context of systemic platelet activation." 07/01/1988 - "Serum from patients with the hemolytic-uremic syndrome (HUS) usually has a diminished ability to support the production of prostacyclin (prostaglandin [PG] I(2)). "
10.	Anti-Bacterial Agents (Antibiotics)IBA 09/01/2013 - "Certain management practices optimize the likelihood of good outcomes, such as avoidance of antibiotics during the pre-hemolytic uremic syndrome phase, admission to hospital, and vigorous intravenous volume expansion using isotonic fluids. " 08/28/2002 - "PubMed and MEDLINE computer searches were performed for studies published from January 1983 to February 2001 using the key words hemolytic uremic syndrome, risk factor, antibiotics, and Escherichia coli O157:H7. " 12/01/2011 - "coli O157:H7 are treated with certain antibiotics, an increased incidence of hemolytic uremic syndrome may result. " 01/01/2008 - "coli O157:H7 progress to hemolytic uremic syndrome, but this figure may reach 50% if antibiotics are used. " 08/22/2000 - "coli, antibiotics and hemolytic-uremic syndrome in children."

Therapies and Procedures

1.	Plasma Exchange 01/01/1984 - "Two adult patients with the hemolytic-uremic syndrome were treated successfully with intense plasma exchange. " 01/01/2012 - "Therapeutic plasma exchange in Streptococcus pneumoniae-associated hemolytic uremic syndrome: a case report." 06/01/2011 - "Early diagnosis and management of postpartum hemolytic uremic syndrome with plasma exchange." 11/01/2002 - "Plasma exchange (PE) therapy was administered to three patients with Escherichia coli O-157 associated hemolytic uremic syndrome (HUS) in early phase. " 11/01/2002 - "Plasma exchange therapy for the treatment of Escherichia coli O-157 associated hemolytic uremic syndrome."
2.	Transplants (Transplant) 01/01/1999 - "Among the 19 patients who entered the protocol, 14 are alive and in clinical, hematological and cytogenetic remission (Ph1-) and 3 patients died due to acute GVHD, 1 due to graft failure and 1 due to Hemolytic Uremic Syndrome. " 01/01/2014 - "Outcome of kidney transplants for adults with hemolytic uremic syndrome in the U.S.: a ten-year database analysis." 11/01/2013 - "Case series: hemolytic uremic syndrome--another cause of transplant dysfunction." 01/01/2011 - "New insights into postrenal transplant hemolytic uremic syndrome." 05/01/2006 - "Graft failure due to hemolytic uremic syndrome recurrence."
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 11/01/2005 - "Hemolytic uremic syndrome after bone marrow transplantation: clinical characteristics and outcome in children." 06/01/1998 - "One hundred and thirteen patients who underwent autologous or allogeneic bone marrow transplantation (BMT) were investigated for the subsequent development of hemolytic uremic syndrome (HUS). " 06/01/1998 - "[Hemolytic uremic syndrome after bone marrow transplantation]." 05/01/1997 - "Hemolytic uremic syndrome (HUS) has been reported in patients receiving bone marrow transplantation. " 01/01/1997 - "Late renal injury after bone marrow transplantation is characterized by a syndrome similar to the hemolytic uremic syndrome. "
4.	Kidney Transplantation 07/01/2015 - "Plasmodium vivax induced hemolytic uremic syndrome: An uncommon manifestation that leads to a grave complication and treated successfully with renal transplantation." 12/01/2015 - "There is currently no large registry study comparing dialysis versus kidney transplantation survival outcomes of waitlisted adults with hemolytic uremic syndrome (HUS). " 12/01/2015 - "Survival With Dialysis Versus Kidney Transplantation in Adult Hemolytic Uremic Syndrome Patients: A Fifteen-Year Study of the Waiting List." 01/01/2011 - "After renal transplantation, hemolytic uremic syndrome (HUS) may occur either as a recurrent or de novo form. " 09/01/2008 - "Hemolytic uremic syndrome recurrence after renal transplantation."
5.	Aftercare (After-Treatment) 11/01/2004 - "Hemolytic uremic syndrome presenting after treatment of endodermal sinus tumor." 05/01/1983 - "The hemolytic-uremic syndrome: recovery after treatment with vincristine." 11/01/2003 - "We report one new case of hemolytic-uremic syndrome (HUS) and one case of digital necrosis after treatment with gemcitabine (Gemzar). " 07/20/1990 - "An autopsy case of hemolytic uremic syndrome after treatment with antineoplastic agents for advanced gastric carcinoma is reported. " 05/01/1985 - "A thrombotic microangiopathy resembling the hemolytic uremic syndrome was diagnosed in 12 patients with adenocarcinoma, in whom the tumor was in complete or near-complete remission after treatment with mitomycin C-containing drug regimens. "