Sickle Hemoglobin

An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.

Also Known As:

Networked: 665 relevant articles (14 outcomes, 43 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gladwin, Mark T: 13 articles (04/2014 - 09/2002)
2.	Steinberg, Martin H: 8 articles (04/2014 - 06/2002)
3.	Buchanan, George R: 7 articles (09/2014 - 10/2003)
4.	Gordeuk, Victor R: 6 articles (04/2014 - 01/2008)
5.	Kato, Gregory J: 6 articles (04/2014 - 01/2006)
6.	Hillery, Cheryl A: 5 articles (10/2015 - 12/2003)
7.	Fairhurst, Rick M: 5 articles (05/2014 - 01/2008)
8.	Wang, Winfred C: 5 articles (02/2013 - 07/2003)
9.	Hebbel, Robert P: 5 articles (03/2012 - 01/2003)
10.	Safo, Martin K: 4 articles (10/2014 - 09/2008)

Related Diseases

1.	Sickle Cell Anemia (Hemoglobin S Disease) 01/01/1983 - "There is no specific therapy for sickle cell disease, and there is no evidence that sickle hemoglobin screening by conventional methods will lead to a significant reduction in the number of children with sickle cell disease. " 01/01/1992 - "Since cell shrinkage adversely influences red cell rheology, it is unlikely that this class of compounds, despite its ability to inhibit hemoglobin S polymerization, will prove useful in the treatment of sickle cell disease." 08/01/2008 - "Using this improved approach, we also generated hES-like cells from homozygous fibroblasts containing the sickle cell anemia mutation Hemoglobin Sickle. " 03/01/2015 - "Studies of hemoglobin S haplotypes in African subpopulations have potential implications for patient care and our understanding of genetic factors that have shaped the prevalence of sickle cell disease (SCD). " 01/01/2013 - "The goal of this study was to evaluate the quality of life of sickle cell disease patients (hemoglobin SS and SC) and their sociodemographic and clinical characteristics. "
2.	Malaria 08/01/2006 - "Hemoglobin S was associated with protection against mild malaria attacks. " 01/01/1992 - "A study was carried out on susceptibility of sicklemia patients to Plasmodium falciparum (PF) malaria in 151 hemoglobin S carriers (homozygous and heterozygous), assisted at the Cotonú Hospital, Benin, for 1 year. " 07/01/2012 - "We report the case of a woman with both malaria and hemoglobin S." 04/29/2011 - "Sickle hemoglobin confers tolerance to Plasmodium infection." 02/01/2009 - "Malaria-infected red blood cells (RBCs) share surface characteristics of hemoglobin S-containing cells. "
3.	Stroke (Strokes) 01/01/2013 - "The second patient had hemoglobin SS and two acute ischemic strokes. " 03/01/2007 - "Although overt stroke occurs in 1 in 10 children with Hemoglobin SS, "silent cerebral infarcts" are even more frequent. " 11/01/2006 - "TCD screening of all children with SCD, and initiation and maintenance of chronic transfusion to maintain hemoglobin S below 30% in the high-risk group, is the only proven prevention strategy for stroke in SCD. " 05/01/2005 - "Cerebral vascular accident (CVA) or stroke is one of the major complications of hemoglobin SS (Hgb SS) disease. " 07/01/2004 - "Hemoglobin SS is the most severe form of SCD and carries an increased risk for stroke. "
4.	Sickle Cell Trait 07/01/2003 - "Among children with sickle cell trait, percentage of hemoglobin S was significantly greater in children who had tortuosity than percentage of hemoglobin S in children who had normal blood vessels at MR angiography (P <.03). " 11/01/2010 - "These studies included 96 patients with hemoglobin SS, SC, and sickle cell trait (AS). " 01/01/2015 - "Sickle cell trait (heterozygosity for hemoglobin S, n = 268) was compared with no sickle cell trait (n = 3748). " 02/24/2011 - "Observed differences indicate the effect of the polymerization of sickle hemoglobin as well as possible changes in the organization of the cell cytoskeleton associated with the sickle cell trait." 02/01/1984 - "However, for purposes of the regulation, sickle cell trait is defined as 41% or less S hemoglobin. "
5.	Falciparum Malaria (Plasmodium falciparum Malaria) 03/01/2009 - "African-Americans (n = 57), nonAfrican-Americans (n = 33), individuals with and without hemoglobin S (n = 15 and n = 12), and children with P falciparum malaria (n = 97) were tested. " 01/01/2003 - "Heterozygosity for the mutant sickle hemoglobin confers protection from severe Plasmodium falciparum malaria. " 02/01/1982 - "The erythrocytes of patients with sickle hemoglobin, diabetes, and Falciparum malaria adhere disproportionately to endothelial cells. " 01/01/1980 - "Population studies in Cameroon: hemoglobin S, glucose-6-phosphate dehydrogenase deficiency and falciparum malaria." 11/01/2005 - "falciparum malaria was close to baseline in children heterozygous with respect to the mutation underlying the hemoglobin S variant and homozygous with respect to the mutation underlying alpha(+)-thalassemia. "

Related Drugs and Biologics

1.	Hydroxyurea (Hydrea)
2.	Fetal Hemoglobin (Hemoglobin F)
3.	Hemoglobin C
4.	beta-Globins (beta Globin)
5.	Oxygen
6.	Hemoglobin A
7.	Hemoglobins (Hemoglobin)
8.	Globins
9.	Retinaldehyde (Retinal)
10.	Lactic Acid

Related Therapies and Procedures

1.	Blood Transfusion (Blood Transfusions)
2.	Drug Therapy (Chemotherapy)
3.	Erythrocyte Transfusion
4.	Homologous Transplantation (Allograft)
5.	Lasers (Laser)