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Hemoglobin SC Disease (Disease, Hemoglobin SC)

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One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia.

Also Known As:

Disease, Hemoglobin SC; Disease, SC; Diseases, Hemoglobin SC; Diseases, SC; Hemoglobin SC Diseases; SC Disease, Hemoglobin; SC Diseases; SC Diseases, Hemoglobin; SC Disease; Sickle Cell Hemoglobin C Disease

Networked: 152 relevant articles (0 outcomes, 14 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Sickle Cell Anemia (Hemoglobin S Disease)
2.	Thalassemia
3.	Sickle Cell Trait
4.	alpha-Thalassemia
5.	Hemolysis

Experts

1.	Hardy-Dessources, Marie-Dominique: 3 articles (02/2015 - 01/2014)
2.	Etienne-Julan, Maryse: 3 articles (02/2015 - 01/2014)
3.	Connes, Philippe: 3 articles (02/2015 - 01/2014)
4.	Lamarre, Yann: 3 articles (02/2015 - 01/2014)
5.	Serjeant, G R: 3 articles (07/2005 - 01/2000)
6.	Colella, Marina P: 2 articles (06/2015 - 04/2015)
7.	Conran, Nicola: 2 articles (06/2015 - 04/2015)
8.	Costa, Fernando F: 2 articles (06/2015 - 04/2015)
9.	Traina, Fabiola: 2 articles (06/2015 - 04/2015)
10.	Romana, Marc: 2 articles (02/2015 - 01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemoglobin SC Disease:

1.	Sickle HemoglobinIBA 08/01/2011 - "The objective of this study was to compare the presentation and clinical course of ACS in individuals with hemoglobin SC disease to that observed in individuals with hemoglobin SS disease. " 08/01/2013 - "Human bulbar conjunctival hemodynamics in hemoglobin SS and SC disease." 11/01/2005 - "Newborn screening of 100000 consecutive deliveries from 1973 to 1981 identified 315 children with homozygous sickle cell (SS) disease and 201 with SS-hemoglobin C (SC) disease. " 07/01/1996 - "Hematologic profile and lymphocyte subpopulations in hemoglobin SC disease: comparison with hemoglobin SS and black controls. " 06/01/1992 - "We report on its adaptation to a diagnostic system for detecting hemoglobin SS and SC diseases. "
2.	Hemoglobins (Hemoglobin)IBA 03/01/1977 - "Hemoglobin studies are presented on two children in whom electrophoretic analysis of hemolysates at alkaline pH initially suggested the diagnosis of hemoglobin SC disease. " 01/01/1956 - "Sickle-cell-hemoglobin-C disease; report of a case with electrophoretic studies of hemoglobin in family members." 08/01/2013 - "The known biophysical variations of hemoglobin (Hb) S and Hb C may result in hemodynamic differences between subjects with SS and SC disease. " 07/01/2007 - "Misleading glycated hemoglobin results in a patient with hemoglobin SC disease." 08/01/2002 - "The mutated hemoglobin HbC (beta 6 Glu-->Lys), in the oxygenated (R) liganded state, forms crystals inside red blood cells of patients with CC and SC diseases. "
3.	Hydroxyurea (Hydrea)FDA LinkGeneric 02/01/2013 - "Hydroxyurea treatment of children with hemoglobin SC disease." 10/01/2003 - "Hydroxyurea-induced splenic regrowth in an adult patient with severe hemoglobin SC disease." 06/01/2001 - "Hydroxyurea therapy for pediatric patients with hemoglobin SC disease." 05/01/2000 - "There was no evidence that hydroxyurea was associated with increased urine concentrating ability in children with Hb SC disease. " 05/01/2000 - "Eight Hb SC disease patients, aged 10 to 17 years, were given hydroxyurea daily. "
4.	Retinaldehyde (Retinal)IBA 06/01/2006 - "This study confirms the frequency and severity of retinal damage in patients with the HbS haemoglobin, particularly among young people with double heterozygous disease (SC) in the tropical African environment. " 04/01/2008 - "We present a case of sickle cell-hemoglobin C disease that presented acute retinal and choroidal peripheral non-perfusion on the base of chronic microvascular obstruction, which transiently closed retinal neovessels." 05/01/2007 - "To report a case of retinal occlusive disease producing binasal visual field defects in a patient with sickle cell (SC) disease. " 11/01/1975 - "Of 45 patients with proliferative sickle retinopathy in stages III, IV, and V, nine patients (eight with hemoglobin SC disease, one with sickle cell thalassemia) showed spontaneous regression (autoinfarction) of retinal sea fans. " 09/01/1994 - "The results have now been analysed in subjects with SS and SC disease using a new classification system based on a comparison of the peripheral retinal vascular bed with that recorded in the cohort with normal haemoglobin (AA) genotype. "
5.	IronIBA 11/01/1980 - "Iron studies in pregnant and non-pregnant women with haemoglobin SS or SC disease." 01/01/1987 - "The relationship between the number of units of blood transfused and indicators of iron status in 37 patients with sickle cell anaemia (Hb SS), SC disease (Hb SC) or S beta-thalassaemia has been studied. " 10/01/2005 - "Children with homozygous sickle cell anaemia (Hb SS) or doubly heterozygous for Hb S and Hb C (Hb SC) disease who had not received a blood transfusion within three months prior to the iron measurements, were enrolled. "
6.	Lactic Acid FDA LinkGeneric 01/01/2011 - "The present study is characterized as a case control study, with the aim of identifying the baseline blood lactate concentration in individuals with hemoglobin SS and SC diseases. " 12/01/1992 - "Arterial blood lactate concentrations obtained on seven black males with hemoglobin sickle cell disease (SC) before, during, and after graded bicycle exercise up to exhaustion were compared with those of seven untrained (HU) and seven trained (HT) healthy males of the same ethnic origin. "
7.	Uric Acid (Urate)IBA 04/01/1989 - "During a study of clinical and laboratory features in 83 patients with sickle cell disease in the Netherlands, serum creatinine, sodium, potassium, uric acid and osmolality were determined and reported for 65: 39 with homozygous sickle cell (SS) disease, 5 with beta degrees thalassaemia (S beta degrees thal), with sickle cell beta + thalassaemia (S beta degrees + thal) and 17 with sickle cell haemoglobin C (SC) disease. "
8.	SodiumIBA 04/01/1989 - "During a study of clinical and laboratory features in 83 patients with sickle cell disease in the Netherlands, serum creatinine, sodium, potassium, uric acid and osmolality were determined and reported for 65: 39 with homozygous sickle cell (SS) disease, 5 with beta degrees thalassaemia (S beta degrees thal), with sickle cell beta + thalassaemia (S beta degrees + thal) and 17 with sickle cell haemoglobin C (SC) disease. "
9.	PotassiumIBA 04/01/1989 - "During a study of clinical and laboratory features in 83 patients with sickle cell disease in the Netherlands, serum creatinine, sodium, potassium, uric acid and osmolality were determined and reported for 65: 39 with homozygous sickle cell (SS) disease, 5 with beta degrees thalassaemia (S beta degrees thal), with sickle cell beta + thalassaemia (S beta degrees + thal) and 17 with sickle cell haemoglobin C (SC) disease. "
10.	MagnesiumIBA 03/01/2011 - "The effects of hydroxycarbamide and magnesium on haemoglobin SC disease: results of the multi-centre CHAMPS trial."

Therapies and Procedures

1.	Prostatectomy (Retropubic Prostatectomy) 04/01/2014 - "Aim of the study is to evaluate the outcome of radical prostatectomy in case of specimen-confined (SC) disease and to compare it with patients with pathological locally-advanced disease. " 04/01/2014 - "One third of patients will present with specimen-confined disease, for which radical prostatectomy represents the sole, initial curative therapy; RP as multimodal therapy in patients without SC disease permits excellent long-term oncological outcomes." 04/01/2014 - "At univariate analysis, age and PSA correlate with the presence of SC disease at radical prostatectomy, while at multivariate analysis only PSA was a significant predictor of SC disease. " 01/01/2014 - "Before radical prostatectomy (RP), a nomogram [Briganti et al., Eur Urol 2012;61:584-592] permits to measure the probability of specimen-confined (SC) disease (pT2-pT3a, node negative with negative margins) in high-risk prostate cancer (PCa). "
2.	Splenectomy 09/01/2009 - "Splenectomy indications and outcome were evaluated in 124 adults with hemoglobin SC disease (Hb SC). " 09/01/2009 - "Acute splenic complications and implications of splenectomy in hemoglobin SC disease." 06/01/1960 - "Sickle cell hemoglobin-C disease treated by splenectomy." 01/01/2006 - "A total of 110 patients with sickle cell disease who had open splenectomy at the University Hospital of the West Indies over a 10-year period are reviewed Patients with homozygous sickle cell disease numbered 94, S beta0 and S beta+ thalassaemias (11 and 4 respectively) and one patient with SC disease. " 10/01/2003 - "We report here our experience with an adult patient with severe SC disease who developed symptomatic splenomegaly requiring splenectomy while being treated with hydroxyurea. "
3.	Transplants (Transplant) 01/01/2005 - "Immunosuppressive therapy for kidney transplant prevents vaso-occlusive crisis in a haemoglobin SC disease patient." 07/01/2001 - "Coronary artery bypass graft surgery in a patient with haemoglobin SC disease." 01/01/2015 - "Only a limited number of patients with sickle cell disease have received liver transplants, and, to our knowledge, this is the first case of ASHC after transplantation in a patient with Hb SC disease. "
4.	Transplantation (Transplant Recipients) 09/01/2008 - "Mobilization, collection, and transplantation of peripheral blood hematopoietic progenitor cells in a patient with multiple myeloma and hemoglobin SC disease." 01/01/2015 - "Only a limited number of patients with sickle cell disease have received liver transplants, and, to our knowledge, this is the first case of ASHC after transplantation in a patient with Hb SC disease. " 06/01/2006 - "Successful mobilization and transplantation of filgrastim mobilized hematopoietic stem cells in sickle cell-hemoglobin C disease."
5.	Blood Transfusion (Blood Transfusions) 11/01/2000 - "We describe a case of a 49 year-old African American gentleman with a history of hemoglobin-SC disease who presented with a severe case of Plasmodium falciparum malaria 3 weeks after having received an infected blood transfusion. " 11/01/1987 - "A woman with sickle cell-hemoglobin C disease developed the acquired immunodeficiency syndrome (AIDS), possibly as the result of blood transfusions administered 4 years earlier. " 10/01/2005 - "Children with homozygous sickle cell anaemia (Hb SS) or doubly heterozygous for Hb S and Hb C (Hb SC) disease who had not received a blood transfusion within three months prior to the iron measurements, were enrolled. "