Hemoglobin J

A group of abnormal hemoglobins with similar electrophoretic characteristics. They have faster electrophoretic mobility and different amino acid substitutions in either the alpha or beta chains than normal adult hemoglobin. Some of the variants produce hematologic abnormalities, others result in no clinical disorders.

Also Known As:

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Loh, Tze Ping: 1 article (01/2013)
2.	Yin, Cecilia: 1 article (01/2013)
3.	Sethi, Sunil K: 1 article (01/2013)
4.	Saw, Sharon: 1 article (01/2013)
5.	Prashanth, G P: 1 article (10/2011)
6.	Hegde, Deeparaj Ganapati: 1 article (10/2011)
7.	Bagalkot, Praveen S: 1 article (10/2011)
8.	Nicol, Kathleen: 1 article (06/2008)
9.	Moder, Phylis: 1 article (06/2008)
10.	Swedan, Nawwar: 1 article (06/2008)

Related Diseases

1.	alpha-Thalassemia 06/09/1978 - "Genetic and biosynthetic studies of families carrying hemoglobin J alpha Mexico: association of alpha-thalassemia with HbJ." 07/01/1988 - "Hemoglobin J (HbJ), Guantanamo, which had been described but once in the literature, was found in a family originating from Benin; this second case was found to be in association with hemoglobin C (HbC) and alpha-thalassemia. "
2.	Disease Progression 11/01/2007 - "Ten independent prognostic factors other than treatment group were identified in multivariate analysis: (a) presence of liver metastases [hazard ratio (HR), 1.66; P = 0.019], (b) number of metastatic sites (HR, 1.63 if > or =2 sites; P = 0.001), (c) clinically significant pain (HR, 1.48; P < 0.0001), (d) Karnofsky performance status (HR, 1.39 if < or =70; P = 0.016), (e) type of progression (HR, 1.37 for measurable disease progression and 1.29 for bone scan progression; P = 0.005 and 0.01, respectively), (f) pretreatment prostate-specific antigen (PSA) doubling time (HR, 1.19 if <55 days; P = 0.066), (g) PSA (HR, 1.17 per log rise; P < 0.0001), (h) tumor grade (HR, 1.18 for high grade; P = 0.069), (i) alkaline phosphatase (HR, 1.27 per log rise; P < 0.0001), and (j) hemoglobin (HR, 1.11 per unit decline; P = 0.004). "
3.	beta-Thalassemia (Cooley's Anemia) 01/01/1996 - "Fortuitous diagnosis of the association of hemoglobin J-Broussais with beta + thalassemia."
4.	Urticaria (Hives) 01/01/1977 - "Hemoglobin J Capetown was found incidentally in a patient of french origin suffering from urticaria with delayed pressure oedema. "
5.	Thalassemia 01/16/2013 - "Our sub-analysis identified 2 cases of α thalassemia, 2 cases of β thalassemia; 5 cases of hemoglobin E variant homozygous, 1 case of hemoglobin J variant, 110 cases of hemoglobin E, 7 cases of hemoglobin S, 1 case of hemoglobin C and 1 case of hemoglobin D, all heterozygous. "

Related Drugs and Biologics

1.	Hemoglobins (Hemoglobin)
2.	Hemoglobin C
3.	Prostate-Specific Antigen (Semenogelase)
4.	Sickle Hemoglobin
5.	Hemoglobin E
6.	Alkaline Phosphatase
7.	hemoglobin D