Hemoglobin E

An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. It is most frequently observed in southeast Asian populations.

Also Known As:

Networked: 315 relevant articles (8 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fucharoen, Suthat: 28 articles (01/2015 - 06/2002)
2.	Chuncharunee, Suporn: 13 articles (08/2015 - 04/2003)
3.	Fucharoen, Supan: 11 articles (08/2015 - 10/2003)
4.	Atichartakarn, Vichai: 9 articles (04/2014 - 04/2003)
5.	Fucharoen, Goonnapa: 9 articles (04/2013 - 10/2003)
6.	Chantharaksri, Udom: 9 articles (01/2012 - 02/2003)
7.	Sanchaisuriya, Kanokwan: 8 articles (06/2010 - 10/2003)
8.	Jetsrisuparb, Arunee: 7 articles (08/2015 - 04/2006)
9.	Olivieri, Nancy F: 7 articles (01/2015 - 01/2005)
10.	Pattanapanyasat, Kovit: 7 articles (01/2015 - 08/2002)

Related Diseases

1.	Malaria 11/01/1987 - "Impaired antioxidant defense in hemoglobin E-containing erythrocytes: a mechanism protective against malaria?" 08/01/2015 - "As part of a malaria study in the Chittagong Hill Districts of Bangladesh, an initial random sample of 202 individuals showed that 39% and 49% of Marma and Khyang ethnic groups, respectively, were positive for either heterozygous or homozygous hemoglobin E. " 03/01/1970 - "[Preliminary results of a study of the relationship between E hemoglobin (Hg E) and paludism in Cambodia]." 04/01/2005 - "Hemoglobin E prevalence in malaria-endemic villages in Myanmar." 11/01/1987 - "Thus impaired antioxidant defense may account for the persistence of the hemoglobin E gene in areas where malaria is endemic. "
2.	beta-Thalassemia (Cooley's Anemia) 01/01/2014 - "Eighty unrelated beta-thalassemia patients were enrolled in this study including 57 with beta-thalassemia/hemoglobin E, eight with homozygous beta-thalassemia, and 15 with heterozygous beta-thalassemia. " 10/01/2012 - "This study investigated whether there were early changes in vascular endothelial function and arterial stiffness in young patients with beta-thalassemia and hemoglobin E, and whether these changes were associated with oxidative stress and expression of antioxidant genes. " 12/01/2009 - "Twenty-three hemoglobin E-beta thalassemia pediatric patients and 24 age-matched controls were recruited in the present study. " 01/01/2005 - "Hemoglobin E-beta-thalassemia: Progress report from the International Study Group." 06/01/1990 - "Clinical and hemodynamic studies were conducted in 6 women and 2 men with beta-thalassemia/hemoglobin E disease. "
3.	Falciparum Malaria (Plasmodium falciparum Malaria) 01/01/1999 - "These results suggest that hemoglobin E trait may ameliorate the course of acute falciparum malaria." 01/01/1999 - "Influence of hemoglobin E trait on the severity of Falciparum malaria." 08/15/2002 - "Hemoglobin E: a balanced polymorphism protective against high parasitemias and thus severe P falciparum malaria." 06/01/2004 - "The hemoglobin E variant (HbE; ( beta )26Glu-->Lys) is concentrated in parts of Southeast Asia where malaria is endemic, and HbE carrier status has been shown to confer some protection against Plasmodium falciparum malaria. " 08/01/2015 - "Hemoglobin E and Glucose-6-Phosphate Dehydrogenase Deficiency and Plasmodium falciparum Malaria in the Chittagong Hill Districts of Bangladesh."
4.	Thalassemia 07/01/2015 - "Improvements in medical facilities have helped a large number of clinically severe hemoglobin E (HbE)-β-thalassemia patients reach adulthood. " 01/01/2015 - "This study investigated the effects of antioxidant cocktails for the treatment of β-thalassemia/hemoglobin E (HbE), which is the most common form of β-thalassemia in Southeast Asia. " 01/01/2002 - "In this study we used two simple laboratory tests to screen for potential thalassemia carriers and hemoglobin E individuals. " 01/01/1980 - "Hemoglobin E-thalassemia: a study of 16 cases." 06/01/1957 - " III. Homozygous hemoglobin E and variants of thalassemia and hemoglobin E; a family study."
5.	alpha-Thalassemia 11/01/2008 - "All forms of alpha-thalassemia including double heterozygote for hemoglobin E and alpha-thalassemia showed significant reduction in hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin with increasing trend of red blood cell as compared with a non-alpha-thalassemic group. " 05/01/2009 - "However, sTfR has never been studied in hemoglobin E (HbE) carriers and their interactions with alpha-thalassemia heterozygotes that are common in Southeast Asia. " 03/01/2005 - "Hemoglobin E levels in double heterozygotes of hemoglobin E and SEA-type alpha-thalassemia." 10/01/2003 - "Molecular and hematologic features of hemoglobin E heterozygotes with different forms of alpha-thalassemia in Thailand." 10/01/2003 - "Interaction of hemoglobin E and several forms of alpha-thalassemia in Cambodian families."

Related Drugs and Biologics

1.	Glutathione (Reduced Glutathione)
2.	Hemoglobins (Hemoglobin)
3.	Iron
4.	Fetal Hemoglobin (Hemoglobin F)
5.	beta-Globins (beta Globin)
6.	Lipoproteins (Lipoprotein)
7.	Proteome
8.	Hydroxyurea (Hydrea)
9.	Thiobarbituric Acid Reactive Substances
10.	Vitamin D

Related Therapies and Procedures

1.	Radiotherapy
2.	Blood Transfusion (Blood Transfusions)
3.	Transplants (Transplant)
4.	Splenectomy
5.	Lasers (Laser)