Hemoglobin C Disease

A disease characterized by compensated hemolysis with a normal hemoglobin level or a mild to moderate anemia. There may be intermittent abdominal discomfort, splenomegaly, and slight jaundice.

Also Known As:

Networked: 20 relevant articles (0 outcomes, 4 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Sickle Cell Anemia (Hemoglobin S Disease)
2.	Hemoglobinopathies
3.	beta-Thalassemia (Cooley's Anemia)
4.	Thalassemia
5.	Anemia

Experts

1.	Ault, Bettina H: 1 article (12/2009)
2.	Sanders, John T: 1 article (12/2009)
3.	Spencer, John David: 1 article (12/2009)
4.	Nagababu, Enika: 1 article (07/2008)
5.	Fabry, Mary E: 1 article (07/2008)
6.	Rifkind, Joseph M: 1 article (07/2008)
7.	Nagel, Ronald L: 1 article (07/2008)
8.	Lee, H E: 1 article (11/2003)
9.	Marder, V J: 1 article (11/2003)
10.	Miller, B J: 1 article (11/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemoglobin C Disease:

1.	Hemoglobins (Hemoglobin)IBA 09/01/1957 - "[Study on hemoglobins; hemoglobin C disease in the white race; 1st case report in Cuba]." 05/01/1985 - "Regulation of cation content and cell volume in hemoglobin erythrocytes from patients with homozygous hemoglobin C disease." 07/01/1962 - "Sickle-cell hemoglobin/hemoglobin-C disease. " 11/01/1987 - "Intraerythrocytic crystallization of hemoglobin is the result of polymerization of the hemoglobin molecules; it occurs in peripheral blood in certain hemoglobinopathies, being more pronounced in hemoglobin C disease. " 02/01/1998 - "Such data provide useful information in the diagnosis of hemoglobinopathies including sickle cell anemia, beta-thalassemia, hemoglobin C disease,etc. In the present investigation, we have explored the determination of absolute concentrations of individual hemoglobins in g/dL and recommend it as an additional parameter which could be included as part of clinical data. "
2.	Hemoglobin CIBA 05/01/1955 - "Homozygous hemoglobin C disease; report of a case with studies on the pathophysiology and neonatal formation of hemoglobin C." 01/08/1981 - "This suggests the possibility of osseous manifestations in the course of hemoglobin C trait or hemoglobin C disease apart from hemoglobin SC disease." 11/01/1954 - "Thalassemia-hemoglobin C disease; a new syndrome presumably due to the combination of the genes for thalassemia and hemoglobin C." 01/08/1981 - "The authors report two cases of hemoglobin C trait and hemoglobin C disease with bone tuberculosis and, in the first case, bone infarction of one condyle two years after the tuberculosis of the other knee. " 12/01/2009 - "Hematuria may be found in patients with sickle cell trait, sickle cell anemia, and sickle cell hemoglobin C disease, but it is believed to be uncommon in patients with other hemoglobinopathies, such as hemoglobin C disease and hemoglobin C trait. "
3.	beta-Globins (beta Globin)IBA 02/01/1972 - "In the present study, the ribosomal assembly of beta-globin chains was examined in the peripheral, nucleated red blood cells and reticulocytes of patients with Cooley's anemia, thalassemia intermedia, sickle thalassemia, sickle cell anemia, hemoglobin C disease, and in hemolytic anemias not associated with a hemoglobinopathy. "
4.	CopperIBA 05/01/1970 - "Fractionation studies of copper in erythrocytes from normal, sickle cell anemia, and hemoglobin C disease."
5.	Hemoglobin AIBA 05/01/1985 - "Erythrocytes from patients with homozygous hemoglobin C disease (CC cells) contain less K, Na, and water than do erythrocytes from normal subjects that contain only hemoglobin A (AA cells). " 01/01/1984 - "The red cells of two patients with homozygous hemoglobin C disease (CC) were found to have reduced cation and water content when compared to the red cells of two normal subjects that contained only hemoglobin A (AA). " 10/15/1984 - "Use of the tool resulted in diagnosis of a hemoglobin disorder in 20% of a group of black patients; diagnoses included alpha-thalassemia trait, beta-thalassemia trait, hemoglobin C trait, hemoglobin S/C disease, hemoglobin S trait, sickle cell anemia, and hemoglobin Lepore. "
6.	Sickle HemoglobinIBA 11/01/2003 - "We report a patient with hemoglobin sickle cell-hemoglobin C disease who developed the clinical syndrome of thrombotic thrombocytopenic purpura (TTP) during admission for typical acute pain crisis. " 10/15/1984 - "Use of the tool resulted in diagnosis of a hemoglobin disorder in 20% of a group of black patients; diagnoses included alpha-thalassemia trait, beta-thalassemia trait, hemoglobin C trait, hemoglobin S/C disease, hemoglobin S trait, sickle cell anemia, and hemoglobin Lepore. "
7.	Pyruvate KinaseIBA 04/01/1990 - "[Chronic non-spherocytic hemolytic anemia caused by pyruvate kinase deficiency in a Costa Rican family carrying hemoglobin C disease]."
8.	IronIBA 07/01/1995 - "Iron deficiency and hemoglobin C disease."
9.	Heme (Haem)IBA 07/01/2008 - "Heme degradation and oxidative stress in murine models for hemoglobinopathies: thalassemia, sickle cell disease and hemoglobin C disease."
10.	Fetal Hemoglobin (Hemoglobin F)IBA 08/01/1985 - "We report the microchromatographic estimation of fetal hemoglobin (Hb F) in 3 conditions associated with hemoglobin C: hemoglobin C-hereditary persistence of fetal hemoglobin (Hb C-HPFH), homozygous hemoglobin C disease, and hemoglobin SC disease. "

Therapies and Procedures

1.	Splenectomy 04/01/2003 - "We consider that in only very few cases of hemoglobin C disease, splenectomy (preceded by prophylactic antipneumococcic vaccine) may be indicated from pain and risk of spontaneous splenic rupture."