Hemoglobin C

A commonly occurring abnormal hemoglobin in which lysine replaces a glutamic acid residue at the sixth position of the beta chains. It results in reduced plasticity of erythrocytes.

Networked: 187 relevant articles (5 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Hemoglobins: 37188
      - Abnormal Hemoglobins: 120
        Hemoglobin C: 187
        glycated hemoglobin C: 7
        hemoglobin C-Harlem: 2
        hemoglobin C Ziguinchor
  - Hemeproteins: 194
    - Globins: 2716
      - Hemoglobins: 37188
        Abnormal Hemoglobins: 120
        Hemoglobin C: 187
        glycated hemoglobin C: 7
        hemoglobin C-Harlem: 2
        hemoglobin C Ziguinchor

Experts

1.	Fairhurst, Rick M: 8 articles (01/2017 - 04/2003)
2.	Wellems, Thomas E: 5 articles (05/2006 - 04/2003)
3.	Doumbo, Ogobara K: 3 articles (10/2017 - 05/2004)
4.	Connes, Philippe: 2 articles (05/2021 - 06/2014)
5.	Derebail, Vimal K: 2 articles (07/2017 - 04/2014)
6.	Galacteros, Frederic: 2 articles (07/2016 - 01/2012)
7.	Hernigou, Philippe: 2 articles (07/2016 - 01/2012)
8.	Coulibaly, Drissa: 2 articles (12/2015 - 05/2004)
9.	Diallo, Dapa A: 2 articles (12/2015 - 05/2004)
10.	Guindo, Aldiouma: 2 articles (12/2015 - 05/2004)

Related Diseases

1.	Malaria 04/15/2003 - "Although selection of hemoglobin C (HbC) by malaria has been speculated for decades, only recently have epidemiologic studies provided support for HbC protection against malaria in West Africa. " 10/27/2017 - "These findings indicate that schoolchildren with hemoglobin C mutation might contribute disproportionately to the seasonal malaria resurgence in parts of West Africa where the HbC variant is common." 12/01/2015 - "Both hemoglobin C and S traits exerted a protective effect against clinical malaria episodes, but appeared to do so by mechanisms that differentially affect the response to infecting malaria parasites." 09/01/2004 - "Hemoglobin C and resistance to severe malaria in Ghanaian children." 01/01/2004 - "Hemoglobin C carriers had less frequent malaria attacks than AA individuals within the same age group (P=0.01). "
2.	Falciparum Malaria (Plasmodium falciparum Malaria) 09/01/2011 - "Hemoglobin C (HbC) has been recently associated with protection against Plasmodium falciparum malaria. " 12/01/2015 - "Hemoglobin C Trait Provides Protection From Clinical Falciparum Malaria in Malian Children." 06/03/2010 - "The high prevalence of hemoglobin S (HbS) in Africa and hemoglobin C (HbC) in parts of West Africa is caused by the strong protection against severe falciparum malaria during childhood. " 01/01/2017 - "Hemoglobin S (HbS) and hemoglobin C (HbC) mutations are frequently encountered in malaria-endemic areas of Africa, where they protect children from severe and uncomplicated Plasmodium falciparum malaria. " 08/15/2015 - "Although hemoglobin S (HbS) and hemoglobin C (HbC) are well known to protect against severe Plasmodium falciparum malaria, conclusive evidence on their role against infection has not yet been obtained. "
3.	Parasitemia 01/01/2004 - "These associations indicate that hemoglobin C reduces parasitemia and confers protection against mild malaria attack." 01/01/2004 - "Analyses that took into account confounding factors confirmed the negative association of hemoglobin C with malaria attack (P=0.0074) and evidenced a negative correlation between hemoglobin C and parasitemia (P=0.0009). " 01/01/2004 - "In a longitudinal study of families living in an endemic area, we investigated whether hemoglobin C is associated with reduced Plasmodium falciparum parasitemia and low risk of mild malaria attack. " 01/01/2004 - "Hemoglobin C is associated with reduced Plasmodium falciparum parasitemia and low risk of mild malaria attack."
4.	Castleman Disease (Castleman's Disease) 04/01/1997 - "Humaniged anti-IL-6 receptor antibody also improved not only the chronic inflammatory symptoms but also laboratory findings such a hemoglobin, C-reactive protein, erythrocyte sedimentation rate observed both in Castleman's disease and in rheumatoid arthritis. "
5.	Rheumatoid Arthritis 04/01/1997 - "Humaniged anti-IL-6 receptor antibody also improved not only the chronic inflammatory symptoms but also laboratory findings such a hemoglobin, C-reactive protein, erythrocyte sedimentation rate observed both in Castleman's disease and in rheumatoid arthritis. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Sickle Hemoglobin
3.	Hemoglobins (Hemoglobin)
4.	Albumins
5.	Ferritins (Ferritin)
6.	Fetal Hemoglobin (Hemoglobin F)
7.	Citric Acid (Citrate)
8.	HLA-B27 Antigen (HLA B27 Antigen)
9.	Phosphates (Orthophosphate)
10.	Lipids

Related Therapies and Procedures

1.	Therapeutics
2.	Central Venous Catheters
3.	Erythrocyte Transfusion
4.	Adjuvant Chemotherapy
5.	Radiotherapy