Hemoglobin C

A commonly occurring abnormal hemoglobin in which lysine replaces a glutamic acid residue at the sixth position of the beta chains. It results in reduced plasticity of erythrocytes.

Also Known As:

Networked: 150 relevant articles (4 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fairhurst, Rick M: 7 articles (05/2014 - 04/2003)
2.	Wellems, Thomas E: 5 articles (05/2006 - 04/2003)
3.	Coulibaly, Drissa: 2 articles (12/2015 - 05/2004)
4.	Guindo, Aldiouma: 2 articles (12/2015 - 05/2004)
5.	Doumbo, Ogobara K: 2 articles (12/2015 - 05/2004)
6.	Plowe, Christopher V: 2 articles (12/2015 - 05/2004)
7.	Diallo, Dapa A: 2 articles (12/2015 - 05/2004)
8.	Taylor, Steve M: 2 articles (05/2014 - 01/2013)
9.	May, Jürgen: 2 articles (06/2010 - 05/2007)
10.	Ehmen, Christa: 2 articles (06/2010 - 05/2007)

Related Diseases

1.	Malaria 04/15/2003 - "Although selection of hemoglobin C (HbC) by malaria has been speculated for decades, only recently have epidemiologic studies provided support for HbC protection against malaria in West Africa. " 12/01/2015 - "Both hemoglobin C and S traits exerted a protective effect against clinical malaria episodes, but appeared to do so by mechanisms that differentially affect the response to infecting malaria parasites." 09/01/2004 - "Hemoglobin C and resistance to severe malaria in Ghanaian children." 01/01/2004 - "Hemoglobin C carriers had less frequent malaria attacks than AA individuals within the same age group (P=0.01). " 01/01/2004 - "In particular, case-control studies have recently shown association between hemoglobin C and resistance to severe malaria in Mali and to clinical malaria in Burkina Faso. "
2.	Falciparum Malaria (Plasmodium falciparum Malaria) 09/01/2011 - "Hemoglobin C (HbC) has been recently associated with protection against Plasmodium falciparum malaria. " 12/01/2015 - "Hemoglobin C Trait Provides Protection From Clinical Falciparum Malaria in Malian Children." 06/03/2010 - "The high prevalence of hemoglobin S (HbS) in Africa and hemoglobin C (HbC) in parts of West Africa is caused by the strong protection against severe falciparum malaria during childhood. " 08/15/2015 - "Although hemoglobin S (HbS) and hemoglobin C (HbC) are well known to protect against severe Plasmodium falciparum malaria, conclusive evidence on their role against infection has not yet been obtained. " 05/01/2014 - "The polymorphisms hemoglobin C (HbC) and hemoglobin S (HbS) - known to protect carriers from severe falciparum malaria - enhance parasite passage to mosquitoes and may promote malaria transmission. "
3.	Parasitemia 01/01/2004 - "These associations indicate that hemoglobin C reduces parasitemia and confers protection against mild malaria attack." 01/01/2004 - "Analyses that took into account confounding factors confirmed the negative association of hemoglobin C with malaria attack (P=0.0074) and evidenced a negative correlation between hemoglobin C and parasitemia (P=0.0009). " 01/01/2004 - "In a longitudinal study of families living in an endemic area, we investigated whether hemoglobin C is associated with reduced Plasmodium falciparum parasitemia and low risk of mild malaria attack. " 01/01/2004 - "Hemoglobin C is associated with reduced Plasmodium falciparum parasitemia and low risk of mild malaria attack."
4.	beta-Thalassemia (Cooley's Anemia) 12/01/2003 - "The present study demonstrates that the red cells of patients with hemoglobin C-beta thalassemia share many characteristics with hemoglobin C red cells, including the decreased osmotic fragility of all cells despite the presence of both spherocytes and target cells. " 12/01/2003 - "Red cell osmotic fragility studies in hemoglobin C-beta thalassemia: osmotically resistant microspherocytes." 08/01/2006 - "The patient was a carrier of double heterozygosis for hemoglobin C/beta-thalassemia. " 01/01/2000 - "Sickle cell hemoglobin C (13 cases) and sickle cell beta-thalassemia (three cases) were uncommon. " 12/01/1999 - "[Clinical, biochemical and metabolic characteristics of a patient with a beta-thalassemia/hemoglobin C genetic compound]."
5.	Thalassemia 07/01/1989 - "Hemoglobin C-beta (0) thalassemia." 10/01/1982 - "Of the affected patients 50% had homozygous sickle cell (SS) disease and 50% had sickle cell-hemoglobin C (SC) or S-thalassemia disease. " 04/23/1977 - "The hemoglobin C thalassemias are less severe and form a fairly homogeneous group. " 01/30/1971 - "[On the association of hemoglobin C and thalassemia]." 07/01/1970 - "[Double heterozygote hemoglobin C--thalassemia in Europeans. "

Related Drugs and Biologics

1.	Sickle Hemoglobin
2.	Hemoglobins (Hemoglobin)
3.	Citric Acid (Citrate)
4.	Agar
5.	Hemoglobin A
6.	Hemoglobin E
7.	Fetal Hemoglobin (Hemoglobin F)
8.	Antigens
9.	hemoglobin D
10.	hemoglobin AA

Related Therapies and Procedures

1.	Catheters
2.	Erythrocyte Transfusion
3.	Adjuvant Chemotherapy
4.	Renal Dialysis (Hemodialysis)
5.	Blood Transfusion (Blood Transfusions)