Heme Oxygenase (Decyclizing) (Heme Oxygenase)

A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme to ferrous iron, carbon monoxide and biliverdin in the presence of molecular oxygen and reduced NADPH. The enzyme is induced by metals, particularly cobalt. EC 1.14.99.3.

Also Known As:

Networked: 817 relevant articles (40 outcomes, 92 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ndisang, Joseph Fomusi: 24 articles (01/2016 - 05/2003)
2.	Jadhav, Ashok: 15 articles (01/2014 - 01/2007)
3.	Abraham, Nader G: 12 articles (01/2015 - 01/2003)
4.	Potter, Richard F: 8 articles (11/2005 - 05/2002)
5.	Otterbein, Leo E: 7 articles (08/2015 - 02/2003)
6.	Wong, Ronald J: 7 articles (05/2015 - 10/2002)
7.	Stec, David E: 7 articles (01/2015 - 04/2005)
8.	Takahashi, Toru: 7 articles (05/2013 - 02/2002)
9.	Bihari, Aurelia: 7 articles (11/2005 - 05/2002)
10.	Vreman, Hendrik J: 6 articles (05/2015 - 10/2002)

Related Diseases

1.	Inflammation 04/01/2006 - "Highly inducible heme oxygenase (HO)-1 is protective against acute and chronic inflammation. " 11/01/2006 - "Heme-oxygenase (HO)-1 acts as an inducible defense against oxidative stress and could play an important role in inflammation models, providing protection against oxidative stress and systemic inflammatory response. " 10/01/2014 - "This study tested the hypothesis that UTI suppresses allergic inflammation by inducing the expression of haem oxygenase 1 (HO1). " 12/01/2009 - "In previous studies, we have shown that heme oxygenase (HO)-2 null [HO-2(-/-)] mice exhibit a faulty response to injury; chronic inflammation and massive neovascularization replaced resolution of inflammation and tissue repair. " 12/01/2008 - "Previous studies have demonstrated that endogenous heme oxygenase (HO)-1 may protect parenchymal tissue from inflammation- and reoxygenation-induced injury. "
2.	Hypertension (High Blood Pressure) 01/01/2012 - "The goal of this study was to test the hypothesis that renal medullary heme oxygenase (HO) acts as a buffer against Ang-II dependent hypertension. " 01/01/2015 - "Heme oxygenase induction attenuates TNF-α-induced hypertension in pregnant rodents." 07/01/2014 - "Redox mechanisms of the beneficial effects of heme oxygenase in hypertension." 01/01/2014 - "Heme oxygenase system and hypertension: a comprehensive insight." 08/01/2012 - "Heme oxygenase (HO) has been shown to be upregulated in patients with OSA and its overexpression in mice causes hypertension. "
3.	Sepsis (Septicemia) 06/01/2011 - "Divergent role of heme oxygenase inhibition in the pathogenesis of sepsis." 11/01/2006 - "We examined whether lympho-histiocytic infiltration of the bone marrow and liver, as well as hemo-/erythrophagocytosis also occurs during sepsis and whether this process could account for the increased production of anti-inflammatory heme-oxygenase (HO-1) products observed during sepsis. " 11/01/2006 - "Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis." 01/01/2006 - "Measures that increase heme oxygenase levels may provide a means of reducing sepsis-induced mitochondrial dysfunction and tissue injury." 04/01/2005 - "The increase in haem oxygenase expression confirms that these cells have been subjected to oxidative stress in sepsis. "
4.	Ischemia 01/01/2015 - "Previous studies have demonstrated that heme oxygenase (HO) induction can block TNF-α pathways in vitro and attenuate placental ischemia-induced sFlt-1 in vivo. " 11/15/2010 - "This study investigated the time course of heme oxygenase (HO)-1 expression and the role of endogenous HO-1 in hepatic ischemia and reperfusion (I/R). " 06/01/1996 - "The results of our study indicate that haem oxygenase is not induced by ischemia, but can be induced by reperfusion. " 09/01/1993 - "The purpose of this study was to determine whether heme oxygenase is expressed as a stress protein after renal ischemia. " 01/01/2013 - "Sexual dimorphism of cardiovascular ischemia susceptibility is mediated by heme oxygenase."
5.	Shock 06/01/2003 - "Heme oxygenase (HO) has both deleterious and protective effects in various shock models. " 06/01/1990 - "This hypothesis is supported by recent studies of the heme oxygenase gene that identified inducer element binding sites responsive to metal administration, heat shock, and nutrient availability. " 11/01/2006 - "We investigated the heme-oxygenase (HO) inhibition during the endotoxemic shock-like conditions. " 03/01/2006 - "Protective mechanisms exist in the brain which are controlled by vitagenes and include members of the heat shock system, heme oxygenase-I, and Hsp70 as critical determinants of brain stress tolerance. " 09/01/2002 - "We found that RBL-2H3 cells respond to heat shock or oxidative injury by the synthesis of both the inducible 72 kDa HSP (Hsp70), and the oxidation-specific 32 kDa heme oxygenase (HO)-1. "

Related Drugs and Biologics

1.	Carbon Monoxide
2.	tin protoporphyrin IX
3.	Nitric Oxide Synthase (NO Synthase)
4.	Hemin (Panhematin)
5.	Bilirubin
6.	Heme (Haem)
7.	Cytokines
8.	Angiotensin II
9.	zinc protoporphyrin
10.	tin mesoporphyrin

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Phototherapy (Light Therapy)
3.	Transplantation (Transplant Recipients)
4.	Spinal Injections
5.	Ligation