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Heme (Haem)

The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.

Also Known As:

Haem; Heme b; Protoheme IX; Ferroprotoporphyrin; Protoheme; Ferrate(2-), (7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, dihydrogen, (SP-4-2)-

Networked: 2992 relevant articles (58 outcomes, 202 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bonkovsky, Herbert L: 18 articles (10/2015 - 02/2002)
2.	Skaar, Eric P: 15 articles (09/2015 - 01/2004)
3.	Takahashi, Toru: 15 articles (02/2012 - 07/2002)
4.	Deybach, Jean-Charles: 14 articles (09/2015 - 01/2002)
5.	Desnick, Robert J: 14 articles (01/2015 - 06/2002)
6.	Morita, Kiyoshi: 13 articles (02/2012 - 07/2002)
7.	Puy, Hervé: 12 articles (09/2015 - 11/2002)
8.	Gouya, Laurent: 12 articles (09/2015 - 01/2002)
9.	Wong, Ronald J: 12 articles (05/2015 - 10/2002)
10.	Furuyama, Kazumichi: 12 articles (07/2014 - 02/2002)

Related Diseases

1.	Inflammation 05/01/2000 - "1. Haem oxygenase-1 (HO-1) can exert protective effects against oxidative stress and inflammation. " 07/01/2014 - "Our study proves that heme is a potential danger activator of NLRP3 inflammasome that plays an essential role in IL-1β secretion during kidney inflammation and provides new insight into the mechanism of innate immune initiation. " 09/01/2009 - "This first study in humans suggests that the clinical expression AIP is associated with a state of under-nutrition and/or with hepatic inflammation due to the sustained accumulation of heme-precursors. " 04/01/2005 - "We used this mouse model to study the development of the injury and to compare the dysfunction of heme synthesis with hepatic gene expression of liver metabolism, oxidative stress, and cellular injury/inflammation. " 11/13/2015 - "Thus, highly oxidizing ferryl Hb and heme, the product of oxidation, may be central to the evolution of vasculopathy in SCD and may suggest therapeutic modalities that interrupt heme-mediated inflammation. "
2.	Ischemia 08/01/2002 - "This study examined the roles of Kupffer cells in the modulation of accelerated heme catabolism in ischemia-reperfused rat livers. " 08/15/1994 - "This study suggests that the signal from non-heme irons detected by ESR can be a good parameter of the metabolic state of the liver in ischemia and reperfusion. " 01/01/1976 - "In a study on rats the relation between graded small bowel ischemia and the concentration of heme compounds in the plasma was investigated. " 03/01/2011 - "Using a multisequence approach comprised of conventional spin echo, inversion recovery, and heme-sensitive gradient echo pulse sequences, MR angiography, and diffusion and perfusion sensitive techniques, MR imaging is capable of identifying vascular lesions, measuring abnormal blood flow, and depicting the metabolic and structural consequences of ischemia. " 06/01/2004 - "Moreover, administration of heme-L-arginate, which is a substrate for HO, produced dilation after ischemia but not after control conditions. "
3.	Wounds and Injuries (Trauma) 09/01/2003 - "Haem oxygenase-1 (HO-1), the rate-limiting enzyme in haem catabolism, is induced by oxidative stress and confers protection against oxidative tissue injuries. " 11/01/2008 - "Thus, free heme-molecule is suggested to possess the activity to initiate or aggravate tissue injuries. " 07/15/2003 - "We observed that heme directly accumulates at the edges of the wound after inflicting a wound in the palate of Wistar rats. " 01/01/1985 - "Trauma does, however, increase the ratio of the fast- to slow-phase components of microsomal heme. " 01/01/1985 - "Non-hepatic regional ischemic trauma results in an increase in the half-life of total microsomal protein, but does not exert the same effect on microsomal heme-associated protein. "
4.	Anemia 12/01/2015 - "Reducing heme synthesis in FLVCR1-defient animals via genetic and biochemical approaches improved the anemia, implying that heme excess causes, and is not just associated with, the erythroid marrow failure. " 12/15/1993 - "Administration of a lower Epo dose (1 U Epo) resulted in only a modest retardation of AZT-induced anemia, although, when combined with heme, there was a great improvement in recovery of erythropoiesis. " 11/01/2013 - "The present study has addressed this problem with the hypothesis that as the Leishmania parasite is completely devoid of heme biosynthetic pathway, therefore the excessive use of heme by the parasites in the human patients can be one of the possible reason of anemia. " 01/01/2005 - "The objective of this study is to verify in male lead exposed workers whether an accurate evaluation of hemocromocytometric parameters and of usual biological indices of lead exposure and effect on heme can differentiate the most common forms of anemia in Southern Italy. " 07/01/2014 - "[Heme metabolism and anemia]."
5.	Acute Intermittent Porphyria (Porphyria, Acute) 02/01/1982 - "Alterations in haem biosynthesis during the human menstrual cycle: studies in normal subjects and patients with latent and active acute intermittent porphyria." 09/25/1971 - "Acute intermittent porphyria: studies of the enzymatic basis of disordered haem biosynthesis." 01/01/2014 - "Acute intermittent porphyria (AIP) is an autosomal dominant genetic defect in heme synthesis. " 01/01/2014 - "Acute intermittent porphyria (AIP) is an autosomal dominant neurovisceral inherited disorder due to a defect in the heme biosynthesis pathway. " 05/01/2012 - "Acute intermittent porphyria (AIP) is a disorder of the heme biosynthesis pathway of a specific inherited enzymatic defect. "

Related Drugs and Biologics

1.	Heme Oxygenase-1
2.	Iron
3.	Carbon Monoxide
4.	tin protoporphyrin IX
5.	Heme Oxygenase (Decyclizing) (Heme Oxygenase)
6.	Cytochromes
7.	Enzymes
8.	Hemoglobins (Hemoglobin)
9.	Biliverdine (Biliverdin)
10.	Oxygenases

Related Therapies and Procedures

1.	Enzyme Replacement Therapy
2.	Plasma Exchange
3.	Intravenous Infusions
4.	Blood Transfusion (Blood Transfusions)
5.	Oral Administration