Hematoporphyrins

Iron-free derivatives of heme with 4 methyl groups, 2 hydroxyethyl groups and 2 propionic acid groups attached to the pyrrole rings. Some of these PHOTOSENSITIZING AGENTS are used in the PHOTOTHERAPY of malignant NEOPLASMS.

Also Known As:

Networked: 324 relevant articles (4 outcomes, 40 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liu, Quanhong: 9 articles (10/2011 - 06/2003)
2.	Wang, Pan: 9 articles (02/2010 - 10/2007)
3.	Tang, Wei: 7 articles (10/2011 - 01/2008)
4.	Wang, Xiaobing: 6 articles (02/2010 - 01/2008)
5.	Zhang, Jing: 5 articles (01/2019 - 03/2008)
6.	Choi, Kyong-Hoon: 3 articles (06/2017 - 02/2015)
7.	Jung, Jin-Seung: 3 articles (06/2017 - 02/2015)
8.	Nam, Ki Chang: 3 articles (06/2017 - 02/2015)
9.	Park, Bong Joo: 3 articles (06/2017 - 02/2015)
10.	Li, Xiaoying: 3 articles (08/2009 - 01/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2007 - "In addition to hematoporphyrin-based drugs, 2nd generation PSs with better photochemical properties are now studied using cell cultures, experimental tumors and clinical trials. " 12/22/2006 - "Experimental study on killing tumor cells by activation of hematoporphyrin derivatives by bi-frequency focal ultrasound in vitro." 09/01/2006 - "As ultrasound has become an important therapeutic technique on tumor, in order to find the cell-killing effect of focused bi-frequency ultrasound activated hematoporphyrin derivatives, experimental study was processed in vitro. " 09/01/2006 - "Experimental study on in vitro tumor cell killing by focused bi-frequency ultrasound activated hematoporphyrin derivatives." 06/01/2004 - "Our study investigated the killing mechanism on S180 tumor cells by using hematoporphyrin and low frequency ultrasound at cell, tissue and individual level."
2.	Cholangiocarcinoma 12/01/2016 - "Treatment of unresectable extrahepatic cholangiocarcinoma using hematoporphyrin photodynamic therapy: A prospective study." 09/01/2009 - "Photodynamic therapy (PDT) with hematoporphyrins has emerged as promising treatment for nonresectable cholangiocarcinoma in several prospective observational studies and two randomized studies. "
3.	Extramammary Paget Disease (Paget Disease, Extramammary) 06/01/2023 - "Efficacy of hematoporphyrin injection (HpD) photodynamic therapy in the treatment of widespread extramammary Paget's disease." 07/31/2023 - "We suggest that hematoporphyrin photodynamic therapy may be an effective alternative to conventional surgery for the treatment of extramammary Paget's disease." 07/31/2023 - "Case Report: Hematoporphyrin Injection (HpD) Photodynamic Therapy for the Treatment of Groin Extramammary Paget's Disease in an Elderly Male Patient."
4.	Liver Neoplasms (Liver Cancer) 11/01/2014 - "Anticancer efficacy of photodynamic therapy with hematoporphyrin-modified, doxorubicin-loaded nanoparticles in liver cancer." 03/01/2012 - "To evaluate the usefulness of hematoporphyrin (HP)-modification of the surface of doxorubicin (DOX)-loaded bovine serum albumin (BSA) nanoparticles (NPs) in the liver cancer-selective delivery of DOX. " 03/01/2012 - "Liver cancer targeting of Doxorubicin with reduced distribution to the heart using hematoporphyrin-modified albumin nanoparticles in rats." 11/01/2014 - "We developed hematoporphyrin (HP)-modified doxorubicin (DOX)-loaded nanoparticles (HP-NPs) to improve the therapeutic effect of PDT in treating liver cancer. "
5.	Photosensitivity Disorders (Photodermatitis) 03/01/1977 - "Additional studies were done in an in vivo model which involves lethal hematoporphyrin photosensitization of white mice. " 02/01/1991 - "Comment on "A guide to the terminology of hematoporphyrin-catalyzed photosensitization" (Michael A. " 05/01/1990 - "Comment on "A guide to the terminology of hematoporphyrin-catalyzed photosensitization"." 10/01/1989 - "Photosensitization of neoplastic tissues with derivatives of hematoporphyrin." 10/01/1986 - "Sites of photosensitization by derivatives of hematoporphyrin."

Related Drugs and Biologics

1.	1-phenyl-3,3-dimethyltriazene (PDT)
2.	Argon
3.	Doxorubicin (Adriamycin)
4.	Rhodamines
5.	Photosensitizing Agents (Photosensitizers)
6.	Folic Acid (Vitamin M)
7.	Hematoporphyrin Derivative
8.	Hemoglobins (Hemoglobin)
9.	Oxygen (Dioxygen)
10.	Gold

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Lasers (Laser)
3.	Intravenous Injections
4.	Phototherapy (Light Therapy)
5.	Therapeutics