Hemarthrosis

01/01/2021 - "Tranexamic Acid Use in Knee and Shoulder Arthroscopy Leads to Improved Outcomes and Fewer Hemarthrosis-Related Complications: A Systematic Review of Level I and II Studies."
11/28/2023 - "Tranexamic acid (TXA) has been increasingly used in arthroscopic surgery to prevent hemarthrosis. "
01/01/2022 - "Administration of Tranexamic Acid to Reduce Intra-articular Hemarthrosis in ACL Reconstruction: A Systematic Review."
01/01/2021 - "To systematically review the literature to compare the efficacy and safety of tranexamic acid (TXA) as a means to minimize hemarthrosis-related complications after arthroscopic procedures of the knee, hip, and shoulder. "
08/01/2018 - "Tranexamic acid (TXA) is an effective agent used for reducing perioperative blood loss and decreasing the potential for postoperative hemarthrosis. "

05/01/2015 - "There is evidence suggesting joint outcomes of hemophilic patients having hemarthrosis despite factor VIII prophylaxis may be much improved if there is access to a center using a procedure similar to the WA protocol."
01/01/2020 - "Factor VIII knockout (FVIII-/-) mice, with or without a FVIII inhibitor, were subjected to hemarthrosis induction and treated with either intravenous (IV) or intraarticular (IA) recombinant human factor VIII (rhFVIII). "
11/01/2019 - "Mechanisms of vascular permeability and remodeling associated with hemarthrosis in factor VIII-deficient mice."
10/08/2019 - "Coagulation factor VIII deficient (FVIII-/-) mice develop an osteoporotic phenotype in the absence of induced hemarthrosis that is exacerbated two weeks after an induced joint injury. "
01/01/2016 - "Factor VIII (FVIII) treated F8(-/-) rats suffered induced hemarthrosis analyzed by histopathology. "

02/01/2006 - "A multicenter randomized open-label crossover prospective trial was designed to compare the efficacy, safety, and cost of standard and high dosages of recombinant factor VIIa (rFVIIa) for home treatment of hemarthroses in hemophiliacs with inhibitors. "
02/01/2006 - "A prospective randomized trial of high and standard dosages of recombinant factor VIIa for treatment of hemarthroses in hemophiliacs with inhibitors."
02/01/2006 - "Our results indicate that a high-dosage regimen with rFVIIa for home treatment of hemarthroses is effective, safe, does not imply an increased consumption of rFVIIa and requires the infusion of a smaller number of rFVIIa doses. "
04/01/2000 - "It is clear that early treatment of acute hemarthroses with rFVIIa results in a greater rate of success, with fewer doses of product being required. "
04/01/2000 - "In the present report, we analyzed the responses to rFVIIa given to treat acute hemarthroses. "

04/01/2019 - "This study shows that joint aspiration under hemostatic cover and in strictly aseptic conditions is a well-tolerated technique that makes the recovery of acute hemarthrosis of hemophilic patients faster."
10/01/2011 - "Bypassing agents offer the potential to close treatment gaps between inhibitor and noninhibitor patients by helping the former better attain key treatment goals, including: facilitating early initiation of treatment and hemostatic control in hemarthroses; providing effective treatment in serious hemorrhagic episodes; and performance of major surgery. "
01/01/2022 - "Common bleeding patterns were epistaxis (73.8%), cutaneous bleeding (52.4%), hematuria (54.8%), menorrhagia (50%) in primary hemostatic defect; cutaneous bleeding (72%), muscle hematoma (58.7%), hemarthrosis (46.7%), menorrhagia (58.7%) in secondary hemostatic defects and epistaxis (45.9%), cutaneous bleeding (62.4%), menorrhagia (30.7%) in normal screening coagulogram group. "
08/01/2008 - "Three recent trials investigating on-demand treatment (Kavakli et al 2006, Santagostino et al 2006, and Young et al 2008) lend further weight to earlier reports demonstrating that a single dose of 270 microg/kg rFVIIa is as effective as a repeat-dose schedule of 3 x 90 microg/kg rFVIIa in producing hemostasis, reducing the need for additional hemostatic medications, and improving pain and mobility in joints affected by hemarthroses. "
01/01/1994 - "P-32 colloid synoviorthesis is a clinically useful out-patient procedure in patients with hemophilia, recurrent hemarthrosis, and synovitis in whom hemostatic therapy has failed."

02/01/1986 - "This study not only validates this method for simulating hemophilic hemarthrosis but also suggests that [99mTc]PYP joint scintigraphy is a simple, and noninvasive method for monitoring the early changes in hemophilic arthropathy and is superior to pertechnetate imaging for this disease process. "

07/01/1985 - "This preliminary study suggests that D-penicillamine is beneficial in the chronic synovitis/arthritis induced by hemarthroses. "
07/01/1985 - "D-penicillamine, a drug effective in the proliferative synovitis of rheumatoid arthritis, was evaluated in a rabbit model of hemarthroses-induced arthritis and in four hemophiliacs with chronic synovitis. "

03/03/2010 - "Two recent prospective, multicenter, randomized trials conducted in Europe (the ESPRIT study) and the USA (the Joint Outcome Study) confirm the efficacy of prophylaxis in the prevention of hemarthroses and arthropathy. "

04/01/2019 - "Patients were infused with the deficient coagulation factor and were instructed to observe relative rest until resolution of hemarthrosis. "
01/01/2018 - "Due to the presence of a hemarthrosis, the patient was treated with clotting factor concentrate. "
06/01/2015 - "Using radioactive synoviorthesis led in decreased consumption of clotting factors and the hemarthrosis incidence in short term but it did not have significant impact on clinical situation (ROM) and radiological findings of hemophilic patients in long-term follow-up."
09/01/2012 - "Early hemarthrosis should be aggressively managed with aspiration and clotting factor concentrate until the joint examination is normal. "
01/01/2012 - "Hemarthroses can be prevented by the administration of clotting factor concentrates (prophylaxis). "

01/01/2017 - "Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis."
01/01/1995 - "This is a case report of a patient with hemophilia B who was treated since childhood with factor IX replacement for recurrent hemarthroses. "
05/11/1985 - "A single dose of 58-102 U/kg of Factor IX (average 80 U/kg) was used in 51 hemarthroses, 13 muscle hematomas and one dental bleed. "
01/01/1979 - "Although patients with severe hemophilia B have lifelong spontaneous hemorrhage and crippling hemarthroses, patients with 0.01--0.03 U/ml Factor IX activity have a milder disease state. "
12/01/2008 - "Factor IX knockout (FIX(-/-)) mice received a puncture of the knee joint capsule with a needle to induce hemarthrosis; human factor IX (hFIX) was either injected through the needle into the joint space (intraarticularly) or immediately delivered IV. FIX(-/-) mice receiving intraarticular FIX protein were protected from synovitis compared with mice receiving same or greater doses of hFIX IV. Next, adeno-associated virus (AAV) gene transfer vectors expressing hFIX were injected into knee joints of FIX(-/-) mice. "

05/01/2015 - "The WA protocol involves a pediatric rheumatologist washing out all acute hemarthrosis of large joints promptly and then instilling intraarticular (IA) corticosteroids. "
03/01/2022 - "Local treatment with intra-articular injections of corticosteroids is an option for refractory cases and physiotherapy has an important role after hemarthrosis and for the long-term management of chronic pain for both pediatric and adult patients. "
07/01/1998 - "Effects of intra-articular vitamin E and corticosteroid injection in experimental hemarthrosis in rabbits."
07/01/1998 - "The effects of intra-articular injections of vitamin E and corticosteroid were investigated in skeletally mature New Zealand white rabbits in which experimental hemarthrosis was induced for 14 days. "
10/01/2021 - "Current major challenges include the absence of the following therapeutic tools for all people with hemophilia (PWH) worldwide: hematological prophylaxis; well-coordinated multidisciplinary teams in specialized centers; joint aspiration of acute hemarthrosis; point-of-care ultrasonography (POC-US); exercise; treatment of synovitis by means of radiosynovectomy; treatment of mild hemophilic arthropathy with analgesics, anti-inflammatory agents, and rehabilitation medicine; intra-articular injections of corticosteroids, hyaluronic acid, platelet-rich plasma, and mesenchymal stem cells; and treatment of severe hemophilic arthropathy by surgical treatment. "

01/01/2018 - "Embolization of the Geniculate Arteries Is an Effective Treatment of Recurrent Hemarthrosis Following Total Knee Arthroplasty That Can Be Safely Repeated."
07/01/2021 - "Selective Embolization Is Safe and Effective for Total Knee Arthroplasty-Associated Recurrent Hemarthroses: A Systematic Review and Meta-Analysis."
01/01/2020 - "Embolization of geniculate arteries is a safe and effective treatment in recurrent hemarthrosis post knee arthroplasty. "
11/01/2015 - "Selective geniculate arterial embolization is an effective and safe treatment modality for recurrent hemarthrosis after knee arthroplasty. "
08/01/2021 - "To investigate the safety and efficacy of genicular artery embolization for treatment of refractory hemarthrosis following total knee arthroplasty. "

09/01/2002 - "In this small series of patients with intermediate follow-up, arthroscopic synovectomy was found to be cost effective in the treatment of patients with recurrent hemarthroses."
07/01/1996 - "Arthroscopic synovectomy was effective in reducing recurrent hemarthrosis and maintaining range of motion; however, joint deterioration continued to occur although probably at a slower rate."
03/01/1997 - "Our data suggest that open synovectomy is effective and safe for reducing the frequency of hemarthrosis and that magnetic resonance imaging should be routinely performed before the procedure."
09/01/1990 - "This study indicates that, with exposure of the ACL substance to the synovial fluid or with hemarthrosis after synovectomy, there is an increase in the degradative activity of the ACL. "
10/01/2022 - "Hemarthrosis is an anecdotal presentation of AVWS and chemical synovectomy was successful in treating this complication. "

01/01/2023 - "Therapy using immersive motion visualization does not cause hemarthrosis. "
01/01/2022 - "Fascial therapy reduces the frequency of hemarthrosis, increases the range of motion and improves the perceived disability in the upper limbs. "
01/01/2021 - "This review confirms that the first line of treatment considered should be the replacement therapy of the coagulation deficient factors that, preventing hemarthrosis, stops the development and progression of ankle's joint damage. "
12/01/2014 - "Definitive therapy involved hemarthrosis aspiration. "
04/03/2013 - "We collected information on age, disease severity, history of shoulder hemarthrosis, prophylaxis therapy, functional Oxford shoulder score, and crutch use. "

08/01/2021 - "Particle embolization is a safe and effective treatment for recurrent hemarthrosis after arthroplasty and our experience suggests that utilizing particle sizes of greater than 300 µm appears to be important in order to avoid cutaneous ischemic complications."
02/01/2017 - "Transarterial embolization for recurrent spontaneous hemarthrosis may be safe and effective in patients having undergone arthroplasty of the affected joint."
02/01/2017 - "We performed a systematic literature review to report the safety and efficacy of transarterial embolization in treating recurrent hemarthrosis in the setting of prior arthroplasty. "
01/01/2009 - "The objective of this study was to describe the angiographic findings of late spontaneous hemarthrosis after total joint arthroplasty and to illustrate the therapeutic role of angiography. "
02/01/2004 - "This study reports the results for 10 patients with recurrent hemarthrosis after knee joint arthroplasty. "

01/01/2019 - "An algorithmic approach is helpful in identifying the etiology of spontaneous recurrent hemarthrosis of knee and a course of conservative treatment should always be the first line of treatment. "
04/13/2022 - "Studies regarding the variables that could predict the success of conservative treatment for knee hemarthrosis are lacking. "
04/13/2022 - "It is necessary to carefully interpret the results of the synovial fluid analysis in patients with knee hemarthrosis; if the synovial fluid analysis shows a synovial RBC count greater than 81,500 and RBC count per HPF greater than 16.3, we recommend immediate interventional angiography rather than continuing conservative treatment."
04/13/2022 - "Patients who underwent interventional angiography and selective embolization after failed conservative treatment for knee hemarthrosis had higher synovial RBC counts and RBC counts per HPF than those with successful outcomes after conservative treatment. "
04/13/2022 - "Twenty-nine patients conservatively treated for knee hemarthrosis were included and divided into two groups: group A comprised 14 patients who underwent interventional angiography and selective embolization due to failed conservative treatment, and group B comprised 15 patients with successful results after conservative treatment. "