Hemangiosarcoma (Angiosarcoma)

A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)

Also Known As:

Networked: 1588 relevant articles (68 outcomes, 111 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Sarcoma (Soft Tissue Sarcoma)
3.	Liposarcoma
4.	Melanoma (Melanoma, Malignant)
5.	Hemangioma (Angioma)

Experts

1.	Penel, Nicolas: 8 articles (09/2015 - 12/2007)
2.	Masuzawa, M: 7 articles (01/2013 - 11/2000)
3.	Maki, Robert G: 7 articles (12/2012 - 05/2005)
4.	Italiano, Antoine: 6 articles (09/2015 - 01/2012)
5.	Chevreau, Christine: 6 articles (09/2015 - 11/2008)
6.	Blay, Jean-Yves: 6 articles (09/2015 - 11/2008)
7.	Masuzawa, Mikio: 6 articles (04/2015 - 01/2002)
8.	Antonescu, Cristina R: 6 articles (03/2015 - 05/2005)
9.	Modiano, Jaime F: 6 articles (09/2014 - 01/2009)
10.	Lazar, Alexander J: 6 articles (04/2014 - 07/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemangiosarcoma:

1.	Doxorubicin (Adriamycin)FDA LinkGeneric 07/01/2002 - "Complete remission of a radio-resistant cutaneous angiosarcoma of the scalp by systemic treatment with liposomal doxorubicin." 10/01/2001 - "Further studies are necessary to prove the efficacy of doxorubicin therapy in angiosarcoma." 01/01/2010 - "Extended remission of metastatic epithelioid angiosarcoma of the heart with liposomal doxorubicin." 03/01/2004 - "The purpose of this study was to evaluate the efficacy and toxicity of a single-agent, dose-intensified doxorubicin protocol in canine hemangiosarcoma (HSA). " 07/01/2008 - "Dogs with subcutaneous hemangiosarcoma had a more favorable outcome, compared with dogs with intramuscular hemangiosarcoma, when treated with adequate local control and adjuvant doxorubicin."
2.	docetaxel (Taxotere)FDA Link 09/01/2012 - "Once the angiosarcoma diagnosis was confirmed histologically, sequential weekly and monthly docetaxel (DTX) treatment was effective in preventing reoccurrence. " 01/01/2015 - "Efficacy of weekly docetaxel in locally advanced cardiac angiosarcoma." 01/01/2012 - "Successful Treatment of MMP-9-Expressing Angiosarcoma with Low-Dose Docetaxel and Bisphosphonate." 05/01/2011 - "[A case of angiosarcoma of the scalp with severe fluid retention after administering docetaxel]." 04/01/2011 - "Treatment of cardiac angiosarcoma with radiation and docetaxel: a case report with partial response and prolonged stable disease."
3.	Paclitaxel (Taxol)FDA LinkGeneric 03/01/2015 - "Both patients showed local recurrence of angiosarcoma after primary surgery, and they achieved complete remission following treatment with weekly paclitaxel. " 07/01/2012 - "Cutaneous angiosarcomas respond favorably to weekly paclitaxel. " 11/10/2008 - "The objective of this phase II trial was to assess the efficacy and toxicity of weekly paclitaxel for patients with metastatic or unresectable angiosarcoma. " 11/10/2008 - "Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study." 11/15/1999 - "Based on a complete response observed in a patient with angiosarcoma of the scalp treated with paclitaxel in a Phase II trial, the authors treated a cohort of patients with angiosarcoma of the scalp or face with paclitaxel as single agent. "
4.	Interleukin-2 (IL2)IBA 04/01/2015 - "Complete remission of treatment-refractory advanced angiosarcoma of the scalp by protracted intralesional interleukin-2 therapy." 12/01/2011 - "Our case is important should recombinant interleukin-2 be considered effective for hepatic angiosarcoma in the future." 11/01/2012 - "[A case of retroperitoneal angiosarcoma effectively treated with recombinant interleukin-2]." 10/01/2013 - "The therapeutic effects of Sendai virus particles (hemagglutinating virus of Japan envelope: HVJ-E) carrying IL-2 gene (HVJ-E/IL-2) were examined in a mouse model of angiosarcoma. " 12/01/2011 - "To our knowledge, there have been no reported cases of hepatic angiosarcoma treated with recombinant interleukin-2. "
5.	taxaneIBA 07/01/2011 - "The purpose of this study was to evaluate the efficacy of taxane regimens in patients with metastatic angiosarcoma. " 07/01/2011 - "Efficacy of taxane regimens in patients with metastatic angiosarcoma." 12/01/2011 - "Angiosarcoma: a study of 98 cases with immunohistochemical evaluation of TLE3, a recently described marker of potential taxane responsiveness." 03/01/2015 - "Among the drugs with demonstrated activity, taxane derivatives are one of the most effective histology-driven treatments against angiosarcomas. " 07/01/2011 - "A taxane regimen may be more effective than a non-taxane regimen for treating patients with metastatic angiosarcoma."
6.	IfosfamideFDA LinkGeneric 05/01/2000 - "Six dogs with splenic hemangiosarcoma received ifosfamide postsplenectomy and their median survival time was 147 days. " 10/01/2014 - "Treatment with liposomal non-pegylated doxorubicin and ifosfamide could be a reasonable option in pleuropulmonary angiosarcoma but it should be validated in clinical trials. " 05/01/1994 - "Treatment of primary ovarian angiosarcoma with ifosfamide and doxorubicin." 05/01/1994 - "A case of primary ovarian angiosarcoma is described in which a short remission was achieved with intensive chemotherapy using ifosfamide and doxorubicin." 07/01/2011 - "We report on the surgical resection of a rare case of giant epithelioid angiosarcoma originating in the anterior mediastinum, followed by six courses of adjuvant chemotherapy (doxorubicin + ifosfamide). "
7.	gemcitabineFDA Link 12/01/2014 - "Gemcitabine-based regimen for primary ovarian angiosarcoma with MYC amplification." 05/01/2012 - "Significant response to gemcitabine monotherapy in primary pleural epithelioid angiosarcoma." 02/01/2012 - "Gemcitabine is active in both RT- and non-RT-related angiosarcoma, with dimensional and possibly long-lasting responses. " 02/01/2012 - "One patient with a locally advanced thyroid angiosarcoma became resectable after 5 months of gemcitabine, with <10% residual viable tumor cells seen on surgical specimen. " 02/01/2012 - "We retrospectively reviewed all cases of advanced progressive angiosarcoma treated with gemcitabine as a single agent (1000 mg/m(2) i.v. every week for 3 weeks every 4 weeks), at Istituto Nazionale Tumori and within the Italian Rare Cancers Network from January 2008 to November 2010. "
8.	bevacizumabFDA Link 07/01/2010 - "Partial response to bevacizumab of an extensive cutaneous angiosarcoma of the face." 01/01/2011 - "Here, we report a case an 88 year old patient with extensive scalp angiosarcoma having biopsy proven remission with bevacizumab and radiotherapy without undergoing surgery." 01/01/2011 - "Scalp Angiosarcoma Remission with Bevacizumab and Radiotherapy without Surgery: A Case Report and Review of the Literature." 11/01/2014 - "This report describes the response to chemotherapy and bevacizumab in a child with angiosarcoma and highlights the potential for malignant transformation of benign vascular lesions and the need for careful monitoring." 06/01/2013 - "This is a case report and review of the literature using bevacizumab and combination chemotherapy for angiosarcoma. "
9.	1-dodecylpyridoxal (PLD)IBA 07/15/2005 - "To better define the efficacy of these agents in angiosarcoma, the authors reviewed their experience with paclitaxel and PLD in patients with angiosarcoma treated between 1994 and 2004. " 07/15/2005 - "The current study demonstrated the activity of PLD (five of six patients experienced clinical benefit) and extended the data on paclitaxel in angiosarcoma, both of the face and scalp, as well as angiosarcoma originating at other sites." 07/15/2005 - "They identified seven patients with angiosarcoma treated with paclitaxel, and six treated with PLD. " 01/01/2006 - "Liposomal doxorubicin (PLD) has been shown to be useful in the treatment of soft tissue sarcomas, and our case supports its use in cardiac angiosarcoma." 07/15/2005 - "Because of the efficacy of PLD in soft tissue sarcoma in general, and in KS in particular, coupled with potential similarities in KS and angiosarcoma, and the apparent activity of paclitaxel in angiosarcomas, the authors treated patients with angiosarcoma with either paclitaxel or PLD as initial chemotherapy. "
10.	TaxoidsIBA 12/01/2011 - "Taxanes may have efficacy in the treatment of angiosarcoma. " 12/01/2007 - "Angiosarcomas and taxanes." 02/01/2006 - "Although the sarcomas in general tend to be relatively refractory to taxanes, there is some evidence that the angiosarcomas may be sensitive to these agents. " 07/01/2012 - "Data regarding the role of anthracyclines and taxanes as first-line treatments of metastatic angiosarcoma are limited. " 07/01/2014 - "Advanced angiosarcoma of face and scalp can be controlled with multiple lines of chemotherapy, consisting primarily of taxanes as well as anthracyclines. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 06/30/2008 - "Transarterial infusion chemotherapy using such a port system may be particularly effective for angiosarcoma in the early stages because small lesions with limited invasion mean a small territory of blood supply to be covered, and useful life was possible because the port system embedded in subcutaneous tissue allows treatment in an out-patient clinic." 06/30/2008 - "Efficacy of selective transarterial chemotherapy using a port systemfor angiosarcomas of the face and scalp." 12/01/2014 - "Our analysis provides a useful measure of angiosarcoma response to chemotherapy for comparison with future clinical trials." 12/01/2006 - "Further studies are needed to establish the role of adjuvant radiation or chemotherapy in the treatment of angiosarcoma." 05/21/2015 - "Palliative chemotherapy is an option in advanced hepatic angiosarcoma. "
2.	Radiotherapy 09/01/2012 - "To the best of our knowledge, this represents only the second case in the literature reporting radiotherapy as a single modality treatment that resulted in complete remission of an angiosarcoma of the face." 04/15/2010 - "The current study was conducted to report the long-term outcomes of a novel approach using hyperfractionated and accelerated radiotherapy (HART) for angiosarcoma developing after BCT. " 03/01/1991 - "Two cases of well-differentiated angiosarcoma following radiotherapy together with an immunocytochemical and electron-microscopical study are reported. " 10/01/2015 - "Rarely, angiosarcomas develop in the breast following conservative therapy, namely radiotherapy. " 05/01/2015 - "Angiosarcoma of the bladder following prostate radiotherapy."
3.	Adjuvant Chemotherapy 02/01/1997 - "Hepatic angiosarcoma in a child: successful therapy with surgery and adjuvant chemotherapy." 09/01/1994 - "We conclude that dermal hemangiosarcomas may be effectively treated with surgery alone, whereas hemangiosarcomas located within the hypodermal tissues bear a poor prognosis and warrant wide surgical excision with adjuvant chemotherapy." 06/01/2014 - "High-grade angiosarcoma of the right atrium successfully targeted with total resection and reconstruction followed by adjuvant chemotherapy." 01/01/2014 - "Cytoreductive surgery and adjuvant chemotherapy remain the primary treatment of angiosarcomas of the ovary." 01/01/2013 - "Primary cardiac angiosarcoma in a 25-year-old man: excision, adjuvant chemotherapy, and multikinase inhibitor therapy."
4.	Aftercare (After-Treatment) 04/05/2009 - "We present a patient with a chronic venous ulceration who developed angiosarcoma of the ulcerated leg with good outcome after treatment. " 12/01/2007 - "In multivariate analysis, favourable prognostic factors for better local control were: no residual tumour after treatment, no cellular pleomorphism, and histology other than angiosarcoma. " 02/01/2007 - "[Three-year survival after treatment of a primary pulmonary angiosarcoma]." 05/01/1993 - "Herein we report a case of primary angiosarcoma of the bladder in a man who had no prior exposure to any of the etiologic factors and is disease free 8 months after treatment with partial cystectomy and adjuvant postoperative pelvic irradiation." 10/01/2008 - "We report a 26 year-old female with a right atrium angiosarcoma with a surprisingly favorable outcome at 2 years follow-up after treatment with a combination of neoadjuvant chemotherapy and surgical resection. "
5.	Splenectomy 01/01/2015 - "The definitive diagnosis and treatment of a splenic angiosarcoma may require splenectomy, although prognosis is poor." 07/01/2014 - "Medical records for 79 dogs with confirmed splenic hemangiosarcoma (HSA) following splenectomy were reviewed for information regarding either the presence or absence of macroscopic liver lesions and the histopathological characteristics of the liver. " 01/01/2014 - "Classic open splenectomy was performed and angiosarcoma of the spleen was the final histopathological diagnosis, which was primary since no other disease site was revealed. " 10/10/2012 - "The first patient was a woman aged 57 years who was referred with metastatic splenic angiosarcoma to the liver, post-splenectomy. " 06/01/2012 - "Splenectomy is the treatment of choice for localized angiosarcomas but a strict follow-up is mandatory because of the possibility of recurrence."