Hemangiosarcoma (Angiosarcoma)

A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)

Also Known As:

Networked: 2408 relevant articles (128 outcomes, 203 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Sarcoma (Soft Tissue Sarcoma)
3.	Neoplasm Metastasis (Metastasis)
4.	Liposarcoma
5.	Hemangiosarcoma (Angiosarcoma)

Experts

1.	Masuzawa, Mikio: 16 articles (11/2020 - 01/2002)
2.	Bryan, Brad A: 12 articles (01/2020 - 01/2013)
3.	Sakai, Hiroki: 11 articles (04/2022 - 03/2007)
4.	Lazar, Alexander J: 11 articles (01/2022 - 07/2010)
5.	Ravi, Vinod: 11 articles (01/2022 - 07/2010)
6.	Blay, Jean-Yves: 10 articles (01/2022 - 11/2008)
7.	Italiano, Antoine: 10 articles (01/2022 - 01/2012)
8.	Kajihara, Ikko: 10 articles (10/2021 - 02/2015)
9.	Modiano, Jaime F: 10 articles (01/2021 - 05/2009)
10.	Ihn, Hironobu: 10 articles (10/2020 - 02/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemangiosarcoma:

1.	Doxorubicin (Adriamycin)FDA LinkGeneric 03/01/2004 - "The purpose of this study was to evaluate the efficacy and toxicity of a single-agent, dose-intensified doxorubicin protocol in canine hemangiosarcoma (HSA). " 11/18/2023 - "Clinical features and prognosis of retroperitoneal hemangiosarcoma in dogs with surgical resection with or without adjuvant doxorubicin." 09/01/2022 - "Canine splenic hemangiosarcoma (HSA) is an aggressive tumour of vascular endothelium that carries a grave prognosis following standard of care treatment with surgery and doxorubicin. " 12/01/2019 - "High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines." 01/01/2019 - "Dendritic cell vaccination plus low-dose doxorubicin for the treatment of spontaneous canine hemangiosarcoma."
2.	Paclitaxel (Taxol)FDA LinkGeneric 04/28/2015 - "Both patients showed local recurrence of angiosarcoma after primary surgery, and they achieved complete remission following treatment with weekly paclitaxel. " 07/01/2012 - "Cutaneous angiosarcomas respond favorably to weekly paclitaxel. " 11/09/2023 - "Efficacy and safety of TM5614 in combination with paclitaxel in the treatment of paclitaxel-resistant cutaneous angiosarcoma: Phase II study protocol." 11/10/2008 - "The objective of this phase II trial was to assess the efficacy and toxicity of weekly paclitaxel for patients with metastatic or unresectable angiosarcoma. " 11/10/2008 - "Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study."
3.	Docetaxel (Taxotere)FDA Link 09/01/2012 - "Once the angiosarcoma diagnosis was confirmed histologically, sequential weekly and monthly docetaxel (DTX) treatment was effective in preventing reoccurrence. " 07/30/2015 - "Efficacy of weekly docetaxel in locally advanced cardiac angiosarcoma." 05/01/2011 - "[A case of angiosarcoma of the scalp with severe fluid retention after administering docetaxel]." 04/01/2011 - "Treatment of cardiac angiosarcoma with radiation and docetaxel: a case report with partial response and prolonged stable disease." 12/01/2007 - "Docetaxel monotherapy for angiosarcoma in an elderly patient."
4.	taxaneIBA 07/01/2011 - "The purpose of this study was to evaluate the efficacy of taxane regimens in patients with metastatic angiosarcoma. " 07/01/2011 - "Efficacy of taxane regimens in patients with metastatic angiosarcoma." 12/01/2011 - "Angiosarcoma: a study of 98 cases with immunohistochemical evaluation of TLE3, a recently described marker of potential taxane responsiveness." 07/01/2023 - "Treatment for taxane-resistant cutaneous angiosarcoma: A multicenter study of 50 Japanese cases." 04/28/2015 - "Among the drugs with demonstrated activity, taxane derivatives are one of the most effective histology-driven treatments against angiosarcomas. "
5.	Propranolol (Inderal)FDA LinkGeneric 01/01/2022 - "The nonselective beta blocker, propranolol, which for decades has been prescribed for the treatment of cardiovascular conditions, has recently been used successfully to treat metastatic angiosarcoma. " 10/01/2020 - "As a result, propranolol has been administered small scale in individual angiosarcoma cases with promising results. " 10/01/2020 - "PropAngio study protocol: a neoadjuvant trial on the efficacy of propranolol monotherapy in cutaneous angiosarcoma-a proof of principle study." 10/01/2020 - "The goal of this neoadjuvant window of opportunity study is to prospectively evaluate the activity of propranolol monotherapy in patients with cutaneous angiosarcoma. " 12/24/2020 - "Given the existing strong rationale for repurposing propranolol in oncology, this therapeutic approach merits further investigation in prospective studies with heart angiosarcoma patients."
6.	GemcitabineFDA Link 07/25/2017 - "In addition, hENT1 overexpression correlated with a significant improvement in PFS (9.3 vs 4.5 months; P=0.02) and OS (20.6 vs 10.8 months; P=0.001) in angiosarcoma patients treated with gemcitabine. " 01/01/2023 - "Single-agent gemcitabine has clinically meaningful activity in advanced, heavily pre-treated angiosarcoma." 01/01/2023 - "We retrospectively reviewed the electronic medical records of consecutive adult patients with advanced angiosarcoma treated with single-agent gemcitabine at our institutions from January 2010 to January 2021. " 01/01/2023 - "Single-agent gemcitabine in patients with advanced, pre-treated angiosarcoma: A multicenter, retrospective study." 12/01/2014 - "Gemcitabine-based regimen for primary ovarian angiosarcoma with MYC amplification."
7.	Taxoids (Taxanes)IBA 12/01/2011 - "Taxanes may have efficacy in the treatment of angiosarcoma. " 12/01/2007 - "Angiosarcomas and taxanes." 01/01/2023 - "Chemoradiotherapy with taxanes is well-recognized as a first-line therapy for cutaneous angiosarcoma (CAS), but second-line therapy for CAS is still controversial. " 02/01/2006 - "Although the sarcomas in general tend to be relatively refractory to taxanes, there is some evidence that the angiosarcomas may be sensitive to these agents. " 11/01/2019 - "Therefore, CCRT with maintenance chemotherapy using taxanes might be effective in treating localized angiosarcomas of the scalp without cervical lymph node metastases."
8.	eribulinFDA Link 01/01/2018 - "Recently, we encountered a case of a heavily pretreated cardiac angiosarcoma that responded well to eribulin treatment. " 01/01/2018 - "Further studies are needed to confirm the benefit of eribulin for patients with angiosarcoma and to establish predictive markers for eribulin sensitivity." 11/01/2020 - "Eribulin for recurrent cutaneous angiosarcoma." 06/01/2018 - "A case of cutaneous angiosarcoma successfully treated with eribulin." 01/01/2018 - "This case suggests that eribulin may be a potential therapeutic option for angiosarcoma. "
9.	Interleukin-2 (IL2)IBA 12/01/2011 - "Our case is important should recombinant interleukin-2 be considered effective for hepatic angiosarcoma in the future." 11/01/2012 - "[A case of retroperitoneal angiosarcoma effectively treated with recombinant interleukin-2]." 12/01/2011 - "To our knowledge, there have been no reported cases of hepatic angiosarcoma treated with recombinant interleukin-2. " 12/01/2011 - "A first case of hepatic angiosarcoma treated with recombinant interleukin-2." 05/01/2006 - "A case of angiosarcoma of the nasal cavity successfully treated with recombinant interleukin-2."
10.	pazopanibFDA Link 01/01/2018 - "A multikinase inhibitor, pazopanib, has been assessed in several studies, most of which support its efficacy for angiosarcoma. " 01/01/2017 - "In conclusion, our case series suggests that pazopanib does not bring remarkable improvement in patients with angiosarcoma." 01/01/2017 - "Pazopanib does not bring remarkable improvement in patients with angiosarcoma." 01/01/2019 - "Herein, we present a case involving recurrent cardiac angiosarcoma where the patient survived for 2 years with complete remission of disease after repeated surgical resection and treatment with oral pazopanib. " 01/01/2017 - "However, the efficacy of pazopanib for cutaneous angiosarcoma has not been confirmed. "

Therapies and Procedures

1.	Therapeutics 01/01/2014 - "Surgical therapy is considered the best choice of therapy approach in cardiac angiosarcoma patients with nonmetastatic disease, even though the disease is rarely cured. " 09/03/2021 - "Primary pleural epithelioid angiosarcoma treated successfully with anti-PD-1 therapy: A rare case report." 01/01/2017 - "Angiosarcoma treated successfully with anti-PD-1 therapy - a case report." 12/01/2004 - "Therefore, a novel antiangiogenic systemic therapy was started that was previously shown to be effective in angiosarcomas other than KS. " 01/01/2022 - "NECTIN4-targeted therapy has the potential to be a novel treatment strategy for angiosarcoma."
2.	Radiotherapy 09/01/2021 - "Therefore, the present study revealed the clinical outcomes of radical radiotherapy for cutaneous angiosarcoma of the scalp." 09/01/2021 - "The present study analyzed 15 consecutive patients treated for cutaneous angiosarcoma of the scalp with radiotherapy between June 2008 and January 2020. " 09/01/2021 - "The aim of the present study was to evaluate the efficacy and feasibility of treating patients with radiotherapy for cutaneous angiosarcoma localized to the scalp at The University of Tokyo Hospital (Tokyo, Japan). " 12/01/2018 - "The present study reports two cases of intra-abdominal angiosarcoma associated with previous radiotherapy treatment. " 12/01/2012 - "We found the association of prostate angiosarcoma with radiation therapy to be weak based upon the results from observational studies and case reports. "
3.	Drug Therapy (Chemotherapy) 12/09/2021 - "Chemotherapy, which is effective in angiosarcoma, is mostly ineffective in EHE. " 06/30/2008 - "Transarterial infusion chemotherapy using such a port system may be particularly effective for angiosarcoma in the early stages because small lesions with limited invasion mean a small territory of blood supply to be covered, and useful life was possible because the port system embedded in subcutaneous tissue allows treatment in an out-patient clinic." 05/31/2018 - "Metastatic or relapsed angiosarcoma has a poor prognosis and the efficacy of conventional chemotherapy is often limited. " 06/30/2008 - "Efficacy of selective transarterial chemotherapy using a port systemfor angiosarcomas of the face and scalp." 01/01/2022 - "Chemotherapy in patients with localized angiosarcoma of any site: A retrospective european study."
4.	Immunotherapy 03/15/2002 - "RT, combined with complete resection or adjuvant rIL-2 immunotherapy, could be a promising treatment strategy, leading to prolonged survival in patients with angiosarcoma." 01/01/2023 - "Advanced diffuse hepatic angiosarcoma treated successfully with TACE and targeted immunotherapy: A case report." 05/01/2023 - "The use of immunotherapy in particular subtypes including head and neck angiosarcomas shows promising results. " 01/01/2019 - "Targeted medicines and immunotherapy have been studied as promising treatment of angiosarcoma. " 02/01/2023 - "Recent studies have demonstrated the clinical benefit of immunotherapies in angiosarcomas. "
5.	Adjuvant Chemotherapy 02/01/1997 - "Hepatic angiosarcoma in a child: successful therapy with surgery and adjuvant chemotherapy." 09/01/1994 - "We conclude that dermal hemangiosarcomas may be effectively treated with surgery alone, whereas hemangiosarcomas located within the hypodermal tissues bear a poor prognosis and warrant wide surgical excision with adjuvant chemotherapy." 01/01/2020 - "Evaluation of the use and efficacy of (neo)adjuvant chemotherapy in angiosarcoma: a multicentre study." 03/01/2023 - "Adjuvant chemotherapy has been shown to improve outcome for canine splenic hemangiosarcoma. " 11/01/2023 - "Adjuvant chemotherapy was not significantly associated with higher overall survival for resected nonmetastatic angiosarcoma of the head and neck. "