Hemangiopericytoma

A tumor composed of spindle cells with a rich vascular network, which apparently arises from pericytes, cells of smooth muscle origin that lie around small vessels. Benign and malignant hemangiopericytomas exist, and the rarity of these lesions has led to considerable confusion in distinguishing between benign and malignant variants. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1364)

Also Known As:

Networked: 329 relevant articles (8 outcomes, 20 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sarcoma (Soft Tissue Sarcoma)
2.	Neoplasms (Cancer)
3.	Meningioma (Meningiomas)
4.	Synovial Sarcoma (Synovioma)
5.	Malignant Fibrous Histiocytoma

Experts

1.	Hornick, Jason L: 3 articles (03/2014 - 02/2006)
2.	Eloy, Jean Anderson: 3 articles (01/2014 - 01/2012)
3.	Liu, James K: 3 articles (01/2014 - 01/2012)
4.	Pollock, Bruce E: 2 articles (10/2014 - 06/2003)
5.	Doyle, Leona A: 2 articles (03/2014 - 05/2011)
6.	Mertens, Fredrik: 2 articles (03/2014 - 05/2011)
7.	Ikeda, Katsuhisa: 2 articles (01/2012 - 12/2011)
8.	Sen, Seema: 2 articles (01/2012 - 03/2007)
9.	Pushker, Neelam: 2 articles (01/2012 - 03/2007)
10.	Park, Min S: 2 articles (11/2011 - 07/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemangiopericytoma:

1.	pazopanibIBA 01/01/2014 - "Pazopanib may be useful for treatment of metastatic hemangiopericytoma, though further studies are needed to confirm the efficacy of this medication and to investigate its molecular mechanism of action. " 01/01/2014 - "Successful use of pazopanib for treatment of refractory metastatic hemangiopericytoma."
2.	Human Growth Hormone (Saizen)FDA LinkGeneric 05/01/1985 - "Total removal of the suprasellar hemangiopericytoma resulted in normalization of the plasma human growth hormone (GH) level and a marked decrease in size of the pulmonary hemangiopericytoma. "
3.	trabectedin (ecteinascidin 743)IBA 09/01/2010 - "Response to trabectedin treatment in a highly pretreated patient with an advanced meningeal hemangiopericytoma." 09/01/2010 - "We report a case of a heavily pretreated metastatic meningeal hemangiopericytoma in which fourth-line chemotherapy with trabectedin, a marine-derived antineoplastic agent effective in treating advanced soft tissue sarcomas, resulted in clinical benefit."
4.	VimentinIBA 01/01/1999 - "Histological examination disclosed the characteristic features of malignant hemangiopericytoma, including the perivascular lamellar growth of atypical mesenchymal cells with vimentin-positive cytoplasm. " 03/01/1989 - "Vimentin was the only intermediate filament expressed in the normal pericytes of human fetal and adult tissues and in the neoplastic pericytes of all of the hemangiopericytomas. " 03/01/1996 - "A second control group of 7 mesotheliomas was positive for cytokeratins and vimentin but not for CD 34 and Faktor VIII. Diagnosis of SFT might be difficult because of its variability in histopathology, sometimes mimicking a hemangiopericytoma or endothelioma. " 01/01/2001 - "In contrast, infantile myofibromatosis, malignant hemangiopericytomas, and fibrous histiocytomas expressed CTGF in both endothelial cells and in vimentin-positive tumor cells, particularly those around the blood vessels. " 03/01/2007 - "Immunohistochemically, the tumor cells were focally positive for CD-68 and negative for S-100, smooth muscle actin, vimentin, and CD-34, which ruled out neurofibroma, leiomyoma, solitary fibrous tumor, and hemangiopericytoma. "
5.	Dermatofibrosarcoma protuberansIBA 01/01/1999 - "Three of them were found in association with classical and/or myxoid dermatofibrosarcoma protuberans, while the fourth tumor was a retroperitoneal malignant hemangiopericytoma where foci with features of GCF were found. " 08/01/1998 - "Among the CD34-positive tumors that showed occasional CD117 reactivity were dermatofibrosarcoma protuberans (1 of 7) and hemangiopericytoma (2 of 10). " 02/25/1998 - "A positive result also was observed in malignant fibrous histiocytoma, dermatofibrosarcoma protuberans, infantile hemangiopericytoma, pleomorphic liposarcoma, and malignant solitary fibrous tumor. " 10/01/1996 - "It may help in differentiating fibromatosis from fibrosarcoma, dermatofibrosarcoma protuberans of low grade malignancy from high grade malignant fibrous histiocytoma and benign hemangiopericytoma from malignant hemangiopericytoma." 11/01/1997 - "The present series describes eight primary malignant melanomas and/or 10 local recurrences/metastases (from eight patients) misdiagnosed as various types of soft tissue tumors: two dermatofibrosarcoma protuberans, two atypical fibroxanthomas, two storiform-pleomorphic malignant fibrous histiocytomas, one myxofibrosarcoma ("myxoid malignant fibrous histiocytoma"), two malignant hemangiopericytomas, and nine malignant schwannomas. "
6.	DNA (Deoxyribonucleic Acid)IBA 02/01/1994 - "DNA flow cytometric analysis of hemangiopericytoma." 02/01/1992 - "The clinicopathologic and the flow cytometric DNA characteristics of 14 patients with sinonasal hemangiopericytomas are presented. " 04/17/1998 - "DNA ploidy and cell-cycle analysis in intracranial meningiomas and hemangiopericytomas: a study with high-resolution DNA flow cytometry." 09/01/1992 - "However, flow cytometrically assessed DNA ploidy has no prognostic value in angiosarcomas or hemangiopericytomas." 02/01/1992 - "Our data suggest that sinonasal hemangiopericytomas are low-grade neoplasms as evidenced by their histomorphology and their DNA content. "
7.	AntibodiesIBA 05/01/1996 - "Other sarcomas including hemangiopericytoma, fascial sarcoma, and undifferentiated sarcoma were negative for all antibodies tested. " 10/01/2003 - "Hierarchical clustering analysis applied to immunostaining results for all 18 antibodies showed that synovial sarcomas, leiomyosarcomas, hemangiopericytomas, and solitary fibrous tumors cluster distinctly, and assigned one case with indeterminate histology as a Ewing sarcoma. " 09/01/1996 - "Hepatomas (4/4), colorectal adenomas (7/7), colorectal carcinomas (4/4), adrenal cortical adenomas (3/3), hemangiopericytomas (15/15), apocrine gland adenocarcinomas (4/5, 80%), and transitional cell carcinomas (2/2) consistently labeled with at least one of the antibodies. " 01/01/2005 - "Differences between endometrial stromal sarcoma and other soft-tissue tumors were detected for all of the immunohistochemical markers (P<0.05), except anti-bcl-2 and AE1/3. Antibodies against CD10 mark a substantial number of hemangiopericytomas and solitary fibrous tumors (albeit not diffusely) and should always be combined with antiestrogen receptor and CD34 when the differential diagnosis includes endometrial stromal sarcoma. " 10/01/1994 - "Like their nonneoplastic cellular counterparts, hepatocellular carcinoma, pancreatic acinar carcinoma and mesenchymal neoplasms including hemangioma and hemangiopericytoma reacted negatively to cytokeratin antibodies. "
8.	DesminIBA 01/01/1991 - "None of the 11 hemangiopericytomas expressed either desmin or muscle actins. " 05/01/1988 - "In all of the three hemangiopericytoma cell cultures, the matrix stained positively for vimentin and desmin. " 12/01/1992 - "In the esophageal metastasis, which showed no histologic features typical of hemangiopericytoma, numerous mitotically active, small, vimentin+, desmin+, alpha-SMA+ cells often maintained shortened processes and tended to form nodular aggregates about capillaries. " 09/01/1988 - "Cultured meningioma cells and hemangiopericytoma cells were positive for anti-vimentin stain, while desmin, actin, alpha-actinin were positive in only hemangiopericytoma cells. " 10/01/2001 - "In this study, the expression of bFGF, vimentin, CD 34, c-kit (or CD 117), desmin, S-100 protein, and alpha-smooth muscle actin (alpha-SMA) in SFTs, hemangiopericytomas (HPC), gastrointestinal stromal tumors (GIST), and dermatofibrosarcoma protuberans (DFSP) were evaluated to assess their usefulness in the differential diagnosis of these lesions. "
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/01/2013 - "Animals with hemangiopericytoma showed higher serum VEGF levels compared to the patients with malignant peripheral nerve sheath. " 01/01/2010 - "Greater intratumoral VEGF was expressed in hemangiopericytomas (P = 0.04). " 03/01/1996 - "We have analyzed the expression of VEGF and its receptors, the related placental growth factor (PlGF) and the endothelial receptors FLT4 and Tie by in situ hybridization in capillary hemangioblastomas and hemangiopericytomas. " 07/01/2010 - "This review highlights the current body of knowledge regarding the role of the vascular endothelial growth factor (VEGF) and its receptor (VEGFR) in angiosarcoma, epithelioid hemangioendothelioma (EHE), and hemangiopericytoma/solitary fibrous tumor (HPC/SFT). " 07/01/2010 - "Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor."
10.	S100 Proteins (S 100 Protein)IBA 04/01/1989 - "This profile of immunoreactivity was also seen in the peripheral hemangiopericytomas, with the exception of single cases that stained focally for EMA and S-100 protein, respectively. " 10/01/2001 - "One solitary fibrous tumor focally stained for S-100 protein and 1 hemangiopericytoma was focally positive for HHF-35. " 10/01/2001 - "In this study, the expression of bFGF, vimentin, CD 34, c-kit (or CD 117), desmin, S-100 protein, and alpha-smooth muscle actin (alpha-SMA) in SFTs, hemangiopericytomas (HPC), gastrointestinal stromal tumors (GIST), and dermatofibrosarcoma protuberans (DFSP) were evaluated to assess their usefulness in the differential diagnosis of these lesions. " 02/01/2006 - "Tissue sections from 10 meningothelial meningiomas, 20 fibrous meningiomas, 10 atypical meningiomas, 7 solitary fibrous tumors of the meninges, 5 meningeal hemangiopericytomas, and 7 vestibular schwannomas were stained immunohistochemically for claudin-1, epithelial membrane antigen, S-100 protein, CD34, and glial fibrillary acidic protein. " 01/01/1985 - "Seventeen meningeal tumors were examined for pathology with electron microscopy and immunohistochemistry including glial fibrillary acidic protein (GFAP), S-100 protein, muramidase, and factor VIII. These tumors included seven meningiomas, one hemangiopericytoma, three meningeal sarcomas (1 pleomorphic-cell type and 2 myxofibrosarcomas), two fibrous histiocytomas, and four malignant melanomas. "

Therapies and Procedures

1.	Radiotherapy 06/01/1984 - "Generally radiotherapy is not considered to be effective for hemangiopericytoma, but sometimes it is. " 11/01/2001 - "We report our experiences of four cases with meningeal hemangiopericytoma treated with surgery and postoperative radiotherapy and survey the literature to elucidate the efficacy of radiotherapy. " 04/01/1988 - "A case of a recurrent hemangiopericytoma of the falx which responded well to radiotherapy is reported. " 06/01/1974 - "Metastatic hemangiopericytoma cured by radiotherapy. " 01/01/2013 - "Hemangiopericytoma of neck extending to craniovertebral junction treated by surgery, pre- and postoperative radiotherapy."
2.	Drug Therapy (Chemotherapy) 01/01/1987 - "[Possible efficacy of chemotherapy in a case of cardiac hemangiopericytoma]." 04/01/1978 - "Thirty-nine chemotherapy trials in 16 patients with metastatic hemangiopericytoma treated at MSKCC and 33 trials from the literature are reviewed. " 01/01/2012 - "Chemotherapy may have a significant role in the treatment of infants with nonoperative malignant hemangiopericytoma." 01/01/2012 - "Infantile hemangiopericytoma of the orbit treated with primary chemotherapy." 09/01/2010 - "The results of chemotherapy in advanced hemangiopericytoma have been disappointing, and they have been particularly poor in cases located in the meninges. "
3.	Adjuvant Radiotherapy 10/01/2015 - "Recent studies suggest aggressive management combining a grossly total resection (GTR) with adjuvant radiotherapy (RT) as a treatment of choice for intracranial hemangiopericytoma (HPC). " 01/01/2015 - "We report a rare case of recurrent IDEM hemangiopericytoma of dorsal spine in a 16-year-old boy treated with surgery and adjuvant radiotherapy. " 02/01/2014 - "The role for adjuvant radiotherapy in the treatment of hemangiopericytoma: a Surveillance, Epidemiology, and End Results analysis." 01/01/2014 - "[Complete radiological response of meningeal hemangiopericytoma after adjuvant radiotherapy to incomplete excision]." 09/01/2010 - "Surgical resection and adjuvant radiotherapy for a large pineal hemangiopericytoma."
4.	Mastectomy (Mammectomy) 03/01/1991 - "The cytodiagnosis was "mesenchymal tumor." Histopathologic study of the mastectomy specimen made the final diagnosis of hemangiopericytoma. "
5.	Lasers (Laser) 07/01/2008 - "Retinoblastoma (Rb) tumor-suppressor pathway alterations in meningeal hemangiopericytomas: High E2F transcription factor 1 expression and loss of Rb expression: study by double immunofluorescence staining and laser-scanning confocal microscopy."