Hemangioma (Angioma)

A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)

Also Known As:

Angioma; Hemangiomas; Chorangioma; Chorangiomas; Chorioangiomas; Hemangiomas, Histiocytoid; Hemangiomas, Intramuscular; Histiocytoid Hemangioma; Histiocytoid Hemangiomas; Intramuscular Hemangioma; Intramuscular Hemangiomas; Chorioangioma; Hemangioma, Histiocytoid; Hemangioma, Intramuscular

Networked: 5157 relevant articles (595 outcomes, 470 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 1324753
- Neoplasms by Histologic Type: 2
  - Vascular Tissue Neoplasms: 141
    - Hemangioma: 5157

Related Diseases

1.	Neoplasms (Cancer)
2.	Hemangioma (Angioma)
3.	Neoplasm Metastasis (Metastasis)
4.	Vascular Malformations
5.	Hemorrhage

Experts

1.	Frieden, Ilona J: 28 articles (01/2021 - 03/2002)
2.	Mulliken, John B: 26 articles (01/2022 - 03/2002)
3.	Bischoff, Joyce: 23 articles (01/2022 - 02/2004)
4.	Huo, Ran: 23 articles (01/2022 - 05/2011)
5.	Lin, Xiaoxi: 23 articles (01/2022 - 03/2002)
6.	Ma, Gang: 23 articles (01/2021 - 03/2008)
7.	Powell, Julie: 21 articles (01/2021 - 01/2006)
8.	Chen, Hui: 19 articles (01/2022 - 03/2008)
9.	Baselga, Eulalia: 18 articles (06/2022 - 04/2008)
10.	Jin, Yunbo: 17 articles (01/2022 - 05/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemangioma:

1.	Propranolol (Inderal)FDA LinkGeneric 10/01/2014 - "The β-blocker propranolol was discovered to be highly effective for the treatment of infantile hemangiomas (IHs), since 2008. " 05/01/2014 - "After initiation of propranolol, most hemangiomas show evidence of significant improvement relatively rapidly, often within days. " 01/01/2014 - "Propranolol is highly effective in the treatment of infantile hemangioma (IH), but important clinical and pharmacological data are lacking. " 01/01/2014 - "Oral propranolol (PRN) has recently been shown to be highly effective for infantile hemangiomas (IHs), and is currently recommended as the first-line treatment of complicated IHs. " 01/01/2013 - "Recent reports of propranolol for the treatment of hemangiomas have led many physicians to question the best treatment strategy for children with vision-threatening hemangiomas. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 02/01/2002 - "Alarming hemangiomas can be successfully treated with corticosteroids. " 11/01/2018 - "First-line treatment for problematic infantile hemangiomas (IH) consists of systemic corticosteroids or, more recently, beta-blockers, while treatment failures or residual lesions may require surgical intervention. " 06/01/2007 - "Oral systemic corticosteroids are the mainstay of treatment for problematic hemangiomas; however, current information is based on anecdotal experience and retrospective studies. " 09/01/2001 - "Systemic corticosteroid treatment seems to be effective for problematic cutaneous hemangiomas of infancy." 09/01/2001 - "Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation."
3.	Timolol (Blocadren)FDA LinkGeneric 10/01/2017 - "Timolol was the most effective in patients aged 5-6 months, in superficial hemangiomas, and in hemangiomas located on the torso. " 11/15/2017 - "Topical timolol is an effective treatment for small infantile hemangioma, with no significant adverse effects noted. " 08/01/2015 - "Topical beta-blockers such as timolol appear to be effective in treating small, superficial infantile hemangiomas. " 09/01/2019 - "Many studies showed promising results for topical timolol especially in the treatment of superficial hemangiomas. " 03/01/2016 - "Topical use of timolol for infantile hemangiomas has recently emerged with promising results. "
4.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 06/01/2004 - "The long-term results of patients with active choroidal hemangioma demonstrate that PDT is a most effective and safe treatment option. " 01/01/2013 - "PDT is effective in eliminating the subretinal fluid and improving vision in patients with circumscribed choroidal hemangioma." 01/01/2014 - "Overlapping-spot PDT under appropriate treatment parameters and strategies is as effective and safe as single-spot PDT for treating symptomatic circumscribed choroidal hemangioma. " 10/31/2022 - "We present a case series of four patients with circumscribed choroidal hemangioma (CCH) treated with half-dose PDT, proposing this as a novel treatment protocol. " 09/01/2003 - "Further studies investigating the efficacy of PDT-BPD for human hemangiomas are warranted."
5.	Bleomycin (Blenoxane)FDA LinkGeneric 01/01/2006 - "Intralesional bleomycin is another method with which to treat hemangiomas in children and may be particularly helpful for large hemangiomas of the head and neck. " 09/01/1997 - "Efficacy of bleomycin treatment for symptomatic hemangiomas in children." 06/01/2023 - "Bleomycin injection is safe, easy and well tolerated method for treatment of head and neck hemangiomas. " 04/16/2023 - "To evaluate and compare the results of the excision and bleomycin injection treatment methods for adult laryngeal hemangiomas (ALHs) located on the arytenoids. " 01/01/2020 - "The 3-D volume (V) change of infantile hemangiomas and the ratio of bleomycin injection to 3-D V before treatment were calculated, and statistical analysis was performed. "
6.	bleomycetinIBA 01/01/2013 - "[Therapeutic mechanism of bleomycin A5 on infancy hemangioma: an experimental study]." 01/31/2019 - "A small incision in the ventral penile area was separated from the location of the hemangioma, which was injected with pingyangmycin again. " 01/31/2019 - "It was treated by injection of pingyangmycin into the hemangioma's lumen and base. " 07/01/2014 - "The data demonstrated that the pro‑apoptotic activity of pingyangmycin against infantile hemangiomas involves p53 pathway activation. " 07/01/2014 - "Pingyangmycin stimulates apoptosis in human hemangioma-derived endothelial cells through activation of the p53 pathway."
7.	SteroidsIBA 12/01/2000 - "The purpose of this study is to show that systemic steroids, with or without short-term intubation after diagnostic bronchoscopy, can be used as a safe and effective alternative in the management of obstructive paediatric subglottic hemangiomas." 01/01/2011 - "Efficacy of intralesional steroid injection in head and neck hemangioma: a systematic review." 01/01/2011 - "A systematic review was done by means of all English publication in PubMed during the period of 1996 to 2008 using the keywords "hemangioma" and "intralesional steroid injection." The studies involved were retrospective and prospective case reviews on using intralesional steroid injection with or without other treatment modalities. " 01/01/2013 - "Infantile hemangioma: treatment with surgery or steroids." 12/01/2011 - "Infantile hepatic hemangioma was totally insensitive to steroid treatment in 3 (23.1%) of the 13 patients, and 9 (47.4%) of the 19 patients required other treatments. "
8.	Interferon-alpha (Interferon Alfa)IBA 12/01/1997 - "Interferon alfa has been used successfully to treat life-threatening hemangiomas, possibly by means of its antiangiogenic activity. " 08/01/2009 - "Interferon-alpha appears to be an effective and well-tolerated treatment for alarming hemangiomas in infancy." 02/01/2000 - "Interferon alpha is an effective treatment for hemangiomas. " 10/01/1999 - "Interferon alfa is effective for treatment of complicated hemangiomas but may cause serious neurological side effects. " 09/01/1998 - "The authors suggest the implementation of a standard procedure for the interruption of interferon alpha 2A treatment in order to avoid this rebound effect and advise on the need for further studies to properly evaluate dosage and administration parameters for interferon alpha 2A in the treatment of difficult hemangioma."
9.	Retinaldehyde (Retinal)IBA 07/01/2006 - "TTT could be an effective treatment for retinal hemangioma." 05/01/2023 - "The anomalous vascular connection in retinal racemose hemangioma seems to originate at the level of the deep capillary plexus in this case; however, larger studies are necessary for corroboration. " 01/01/2018 - "In this study, the authors evaluate the retinal and choroidal microvascular architecture of the macula in a patient with choroidal hemangioma using OCTA. " 02/01/2009 - "Our study reports a previously described family (IFCAS-07) with 12 members affected by autosomal dominant cavernous angiomas: 11 had CCM either alone or associated with hepatic or retinal angiomas, and one had only hepatic angioma. " 11/01/2023 - "RETINAL HYPOPERFUSION DETECTED BY WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY IN A CASE OF RETINAL RACEMOSE HEMANGIOMA."
10.	SolutionsIBA 01/01/1997 - "Complicated hemangiomas are unique problems in which intervention with the proper laser can be an ideal solution. " 09/01/2022 - "Wide resection as a solution to excruciating pain in intraneural hemangioma: Follow-up of a previously published case report." 01/01/2015 - "Oral propranolol has improved the treatment of infantile hemangiomas, and a pediatric oral solution of propranolol has recently been licensed in the USA and Europe. " 10/01/2021 - "Complicated Infantile Hemangioma Successfully Treated with Topical Timolol 0.5% Solution: A Case Report." 10/01/2021 - "Finally, after 115 days of treatment with itraconazole oral solution (the total dose was about 4025 mg), the refractory infantile hemangioma was successfully treated. "

Therapies and Procedures

1.	Therapeutics 01/01/2013 - "Treatment of infantile hemangiomas with oral beta-blocker therapy is highly effective and well tolerated, with more than 94% of patients demonstrating a response to treatment and 90% showing resolution of the primary functional indication for treatment. " 03/01/2014 - "Oral and topical ß-blocker therapy has become the de facto first-line treatment for complicated infantile hemangiomas because of its superior efficacy and tolerability. " 08/01/2010 - "Injection therapy is effective for children with superficial hemangioma, but we should arrange individualized treatment according to the local blood flow in children." 04/01/2007 - "The abnormal persistence of vessels makes therapy difficult because these lesions are resistant to interventions that are effective against hemangiomas. " 05/01/1997 - "Interferon-alpha-2b therapy is an effective, well-tolerated treatment for complicated hemangiomas. "
2.	Lasers (Laser) 09/01/2010 - "Letter regarding early laser treatment of periorbital infantile hemangiomas may work, but is it really the best treatment option?" 09/01/2010 - "Letter regarding early laser treatment of periorbital infantile hemangiomas may work, but is it really the best treatment option?" 05/01/2010 - "Commentary: Early laser treatment of periorbital infantile hemangiomas may work, but is it really the best treatment option?" 12/01/2022 - "According to this data, it seems to be effective in optimizing lasers parameters for the hemangioma treatment." 07/01/2013 - "Of the possible treatments for hemangiomas, lasers have been shown to be effective in all phases of development. "
3.	Dye Lasers 01/01/2012 - "Pulsed dye laser has proven effective in the treatment of ulcerated hemangiomas. " 11/01/2016 - "Pulsed dye laser (PDL) treatment has been shown to be effective for the management of ulcerated areas of hemangiomas. " 01/01/2014 - "Pulsed dye laser has been proved to be fairly effective in the treatment of infantile hemangioma. " 01/01/2014 - "595 nm pulsed dye laser provides a safe and effective modality with lower morbidity for hand hemangioma." 02/01/2006 - "Pulsed dye laser (PDL) has been reported to be safe and effective in the management of superficial hemangiomas of infancy. "
4.	Solid-State Lasers 05/01/2023 - "KTP laser treatment might be an effective treatment for adult patients with pharyngolaryngeal hemangioma. " 07/26/2019 - "We have previously proved that treatment of thick/deep infantile hemangiomas (IHs) with a long-pulse Alexandrite laser was clinically effective and safe. " 07/01/2015 - "Older age and superficial hemangioma were the primary factors contributing to greater efficacy of long-pulse 1,064-nm Nd:YAG laser treatment for IHs. " 06/01/2006 - "To evaluate the clinical therapeutic efficacy on hemangioma of oral maxillofacial regions using pulsed Gentle YAG laser. " 01/01/1998 - "Nd:YAG-laser treatment is a safe and effective therapeutic measure for eliminating respiratory tract obstruction caused by hemangiomas."
5.	Photochemotherapy (Photodynamic Therapy) 01/01/2014 - "Photodynamic therapy was effective in the treatment of infantile hemangioma. " 09/01/2002 - "Photodynamic therapy seems to be effective in the management of circumscribed choroidal hemangioma. " 01/01/2022 - "Double-fluence photodynamic therapy is a safe and effective treatment for circumscribed choroidal hemangiomas and should be considered as the first line of treatment for these lesions." 09/01/2020 - "In our series, photodynamic therapy was a safe and effective treatment for circumscribed choroidal hemangioma during long-term follow-up. " 10/31/2022 - "Half-Dose Photodynamic Therapy as a Novel Treatment Protocol for Circumscribed Choroidal Hemangioma."