Helium

Helium. A noble gas with the atomic symbol He, atomic number 2, and atomic weight 4.003. It is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. It was first detected in the sun and is now obtained from natural gas. Medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics. (Dorland, 27th ed)

Networked: 1111 relevant articles (58 outcomes, 129 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Preckel, Benedikt: 8 articles (01/2015 - 06/2010)
2.	Jacobi, C A: 7 articles (10/2005 - 01/2000)
3.	Watson, D I: 6 articles (12/2003 - 08/2000)
4.	Weber, Nina C: 5 articles (01/2015 - 06/2010)
5.	Katz, Ira M: 5 articles (01/2015 - 04/2011)
6.	Martin, Andrew R: 5 articles (01/2015 - 04/2011)
7.	Hollmann, Markus W: 5 articles (01/2015 - 06/2010)
8.	Texereau, Joëlle: 5 articles (01/2015 - 04/2011)
9.	Junge, K: 5 articles (11/2011 - 08/2004)
10.	Rosch, R: 5 articles (11/2011 - 04/2000)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2003 - "After exposure of neoplastic tissue to helium, a significant reduction of tumor growth has been detected in experimental studies, both in vitro and in vivo. " 09/01/2015 - "Nevertheless, additional biological experiments and treatment planning studies with larger patient numbers and more tumor indications are necessary to study the possible benefits of helium ion beam therapy in detail." 08/01/2004 - "The objective of this study is to assess tumor growth after air and helium insufflation at different pressures. " 04/01/2001 - "The UCSF-LBL trial mentioned previously, which compared helium ion therapy with 125I episcleral plaque treatment, has documented the superiority of charged particle therapy to plaque therapy in terms of local tumor control and eye retention. " 11/01/1998 - "In this study, helium was associated with reduced tumor growth."
2.	Pneumoperitoneum 05/01/2008 - "Helium ameliorates renal alterations when used for pneumoperitoneum, and it might be used for patients with compromised renal function who have to undergo laparoscopic surgery." 12/01/2006 - "Improved abdominal wall wound healing by helium pneumoperitoneum." 01/01/2005 - "The aim of this study was to investigate the effect of CO2 and helium pneumoperitoneum on the recovery of postoperative gastrointestinal motility. " 09/01/2002 - "For this study, 30 male WAG/Rij rats were randomized into two groups to obtain pneumoperitoneum with CO2 (n=15) or helium (n = 15). " 07/01/2002 - "Therefore, the aim of this study was to investigate in spontaneously breathing rats the effects of CO2 and helium, insufflation pressure, and duration of pneumoperitoneum on blood pressure, arterial pH, pCO2, pO2, HCO3-, base excess, and respiratory rate. "
3.	Dyspnea (Shortness of Breath) 01/01/1986 - "This entity of upper airway dysfunction was responsible for, or at least contributed to, the respiratory symptoms as evidenced by dramatic relief of dyspnea following tracheostomy in one patient, and significant improvement of flow rates following helium breathing in the other 2 patients. " 05/01/2011 - "Moreover, helium:oxygen more potently improved systolic pressure, mean arterial pressure, pulse rate, respiratory rate, and dyspnea (P values: .012, .048, <.001, <.001, and .012, respectively). " 05/01/2011 - "Both air:oxygen and helium:oxygen significantly decreased systolic blood pressure, diastolic blood pressure, mean arterial pressure, pulse rate, respiratory rate, dyspnea, and increased oxygen saturation (P values: .007, .029, .002, <.001, <.001, <.001, and .002 for air:oxygen, respectively, and <.001, .020, .001, <.001, <.001, <.001, and .002, for helium:oxygen, respectively). " 03/01/2011 - "Despite these different responses, helium-oxygen and pressure-support caused similar increases in exercise duration (oxygen-alone: 6.9 ± 0.8 min; helium-oxygen: 10.7 ± 1.4 min; pressure-support: 11.2 ± 1.6 min; p = 0.003) and similar decreases in inspiratory effort (esophageal pressure-time product), respiratory drive, pulmonary resistance, dyspnea and leg effort (p < 0.03). " 10/01/2006 - "At an isotime during exercise, all three gases reduced dyspnea and both helium mixtures increased IC and tidal volume. "
4.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2011 - "One study reported a helium-induced beneficial effect on surrogates of work of breathing after extubation in non-COPD patients, possibly in relation to laryngeal consequences of tracheal intubation. " 01/01/2010 - "Despite small trends favoring helium, this study did not show a statistical superiority of using helium during NIV to decrease the intubation rate in acute exacerbation of chronic obstructive pulmonary disease." 04/01/1989 - "To study this effect in patients, we measured functional residual capacity (FRC) by helium dilution at rest and during low-load supine exercise in 30 patients with chronic obstructive pulmonary disease. " 10/01/2011 - "To evaluate short-acting bronchodilator effects in chronic obstructive pulmonary disease (COPD) by using hyperpolarized helium 3 (³He) magnetic resonance (MR) imaging, spirometry, and plethysmography. " 06/01/2011 - "Effect of helium breathing on intercostal and quadriceps muscle blood flow during exercise in COPD patients."
5.	Asthma (Bronchial Asthma) 04/01/1976 - "The effect of breathing helium on maximal expiratory flow at 50 per cent of vital capacity (V50) was studied in 27 patients with asthma during remission and during induced bronchoconstriction. " 06/01/2011 - "The imaging techniques used to investigate patients with asthma and to assess the effects of asthma treatments include computed tomography (CT), helium magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), and positron-emission tomography (PET). " 04/01/2009 - "The imaging techniques that have been used in the exploration and evaluation of treatment in asthma include computed tomography (CT), helium-magnetic resonance imaging (MRI), single photon emission computerized tomoscintigraphy (SPECT) and positron emission tomography (PET). " 02/01/2009 - "To determine changes in regional airflow obstruction over time in the lungs of patients with asthma, as demonstrated with hyperpolarized helium 3 ((3)He) magnetic resonance (MR) imaging, and to assess correlations with disease severity and use of asthma medications. " 12/01/2005 - "No differences were noted between the control and helium groups with respect to age (1.0 vs 1.1 months), prematurity, or family history of asthma or smoking. "

Related Drugs and Biologics

1.	Oxygen
2.	Argon
3.	Ions
4.	heliox
5.	Nitrogen
6.	Protons (Proton)
7.	Gases
8.	Xenon
9.	Carbon
10.	Noble Gases (Rare Gases)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Cryosurgery
3.	Radiotherapy
4.	Laser Therapy (Surgery, Laser)
5.	Gas Lasers