Atrial Heart Septal Defects (Atrial Septal Defect)

Developmental abnormalities in any portion of the ATRIAL SEPTUM resulting in abnormal communications between the two upper chambers of the heart. Classification of atrial septal defects is based on location of the communication and types of incomplete fusion of atrial septa with the ENDOCARDIAL CUSHIONS in the fetal heart. They include ostium primum, ostium secundum, sinus venosus, and coronary sinus defects.

Also Known As:

Networked: 1789 relevant articles (52 outcomes, 99 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Patent Foramen Ovale
2.	Ventricular Heart Septal Defects (Ventricular Septal Defect)
3.	Eisenmenger Complex (Eisenmenger's Syndrome)
4.	Tetralogy of Fallot (Fallot Tetralogy)
5.	Ebstein Anomaly (Ebsteins Anomaly)

Experts

1.	Hijazi, Ziyad M: 23 articles (12/2011 - 06/2002)
2.	Cao, Qi-Ling: 11 articles (10/2011 - 08/2002)
3.	National Birth Defects Prevention Study: 10 articles (10/2015 - 07/2007)
4.	Lange, P E: 10 articles (08/2005 - 01/2000)
5.	Berger, F: 9 articles (02/2006 - 06/2000)
6.	Rigatelli, Gianluca: 8 articles (06/2011 - 01/2003)
7.	Connolly, Heidi M: 7 articles (11/2015 - 01/2004)
8.	Dearani, Joseph A: 7 articles (10/2014 - 07/2005)
9.	Podolec, Piotr: 7 articles (01/2014 - 01/2004)
10.	Ewert, P: 7 articles (02/2006 - 09/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Atrial Heart Septal Defects:

1.	CosmeticsIBA 11/01/2000 - "The improved cosmetic appearance, both in males and females, is an important factor to recommend minimally invasive repair of atrial septal defects in an adult population. " 07/01/2014 - "The TTS technique and RVIAT can both be performed with favorable cosmetic and acceptable clinical results for closing atrial septal defects. " 01/01/2010 - "Port-access minimally invasive surgery for atrial septal defects is a safe, less-invasive, reproducible, and cosmetic operation, providing an excellent outcome and an effective correction, and could be now considered the standard approach for this type of patient." 01/01/2008 - "We assessed surgical, cosmetic, and psychological results of 3 different surgical approaches to atrial-septal defect repair. " 10/01/2007 - "Intraoperative device closure is a safe, cost-effective, cosmetic, and less-invasive operation of most secundum atrial septal defects. "
2.	Coarctation of the aortaIBA 08/01/2012 - "We present the case of an infant with Shone's syndrome, left ventricular hypoplasia, and a large ostium secundum atrial septal defect who developed pulmonary overcirculation following repair of coarctation of the aorta. " 07/01/2012 - "In some cases, it is associated with congenital malformations such as coarctation of the aorta or atrial septal defects. " 11/01/2007 - "A male infant presented at birth with severe coarctation of the aorta and marginal left ventricular and mitral valve dimensions associated with a large secundum atrial septal defect. " 09/01/2006 - "It is extremely rare the association of coarctation of the aorta with an atrial septal defect. " 09/01/2006 - "They are associated in 10% of cases with a bicuspid aortic valve and less frequently with coarctation of the aorta and atrial septal defect. "
3.	OxygenIBA 04/01/2009 - "Functional capacity according to New York Heart Association functional class and peak oxygen uptake (VO(2)max) in the cardiopulmonary exercise testing improved significantly after atrial septal defects closure, especially in patients with a pulmonary-to-systemic flow ratio >2. Echocardiographic measurements of the right ventricular end-diastolic diameter showed a significant decrease. " 11/01/2010 - "Two patients had simultaneous oxygen desaturation below 80% and right ventricular systolic pressure above 50 mm Hg. Moderate altitude affects right ventricular systolic pressure and oxygen saturation in adolescents with surgically closed ventricular or atrial septal defects. " 11/01/2010 - "Patients successfully weaned were compared with those who had failed weaning in terms of atrial septal defect (ASD) size, ductus arteriosus size, and the transcutaneous oxygen saturation. " 02/01/2010 - "PFO, atrial septal defects, as well as pulmonary right-to-left shunts are usually associated with a various degree of arterial blood oxygen desaturation. " 11/01/2008 - "Among 19 neonates, a larger atrial septal defect was associated with higher oxygen saturation and less need for intervention prior to surgical single-ventricle palliation. "
4.	IceIBA 01/01/2015 - "The aim of this study was to investigate the clinical outcome of intracardiac echocardiography (ICE) for transcatheter closure of atrial septal defect (ASD) compared with the trans-esophageal echocardiography (TEE) guided method. " 01/01/2015 - "The aim of this study was to investigate the clinical outcome of intracardiac echocardiography (ICE) for transcatheter closure of atrial septal defect (ASD) compared with the trans-esophageal echocardiography (TEE) guided method. " 02/01/2007 - "This study sought to compare intracardiac echocardiography (ICE) with conventional quantitative cineangiography (QCA) for balloon-sizing of atrial septal defects (ASD) in order to develop a safe alternative to that radiation-exposing part of device-closure procedures. " 01/15/2003 - "This study was designed to determine the feasibility and accuracy of intracardiac echocardiography (ICE) in guiding percutaneous closure of atrial septal defects (ASD). " 09/01/2014 - "We herein discuss the clinical utility of both TEE and ICE during the procedure of device closure of atrial septal defect."
5.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 11/01/2009 - "This study evaluated the effectiveness of acetylsalicylic acid (ASA) prophylaxis in preventing PPS after surgical closure of atrial septal defects (ASDs) in pediatric patients. " 01/01/2013 - "Her atrial septal defect was closed, she was placed on aspirin therapy, and has not had any recurrent events. " 01/01/2005 - "Aspirin has been routinely prescribed following transcatheter closure of secundum atrial septal defects (ASDs) but its rationale has not been clinically or biologically evaluated; and despite aspirin, thrombotic complications occur following transcatheter ASD closure. " 11/01/2009 - "The effect of short-term prophylactic acetylsalicylic acid on the incidence of postpericardiotomy syndrome after surgical closure of atrial septal defects." 12/01/2014 - "Platelet activation through the efficacy of aspirin in congenital heart disease patients undergoing transcatheter closure of atrial septal defects or ventricular septal defects."
6.	Pulmonary venous return anomalyIBA 05/01/1994 - "Transesophageal color Doppler and two-dimensional echocardiography are very useful in diagnosing sinus venosus atrial septal defect and combined partial anomalous pulmonary venous return." 10/01/1989 - "The present study was to evaluate the diagnostic information that may be obtained in patients with atrial septal defect (ASD) and/or with anomalous pulmonary venous return using spin echo and gradient echo magnetic resonance imaging (MRI). " 07/21/2015 - "Supra-cardiac type (1a) total anomalous pulmonary venous return with right to left shunt atrial septal defect diagnosed by 320 slice CT." 01/01/2015 - "Cardiac CT was carried out; the patient was found to have a sinus venosus atrial septal defect with partial anomalous pulmonary venous return. " 12/01/2014 - "Sinus venosus atrial septal defect (ASD) is usually associated with partial anomalous pulmonary venous return (PAPVR) of the right pulmonary veins to the superior vena cava (SVC), or to the SVC-right atrial junction. "
7.	sildenafil (Viagra)FDA Link 05/01/2010 - "She underwent successful corrective repair of atrial septal defect after 2 years of treatment with sildenafil, and has been monitored for 4 years after repair. " 05/31/2007 - "The effects of sildenafil in severe PAH associated with an atrial septal defect (ASD) have not been clearly delineated. " 05/01/2010 - "Repair of atrial septal defect with Eisenmenger syndrome after long-term sildenafil therapy." 12/01/2011 - "Comparative efficacy of sildenafil in Eisenmenger's syndrome secondary to atrial septal defect versus ventricular septal defect: a cardiac catheterisation follow-up study." 12/01/2011 - "This study evaluates the efficacy and safety of sildenafil in patients with Eisenmenger's syndrome with special emphasis on haemodynamic parameters and its comparative efficacy in atrial septal defect versus ventricular septal defect patients. "
8.	nitinolIBA 01/01/2013 - "Atrial septal defect (ASD) was closed percutaneously in an 18-year-old boy with a 27 mm nitinol wire mesh occluder according to standard procedures. " 01/01/2013 - "Early neurological complications after transcatheter closure of atrial septal defect with nitinol wire mesh occluder." 04/01/2010 - "The Occlutech Figulla PFO and ASD occluder: a new nitinol wire mesh device for closure of atrial septal defects." 06/01/2008 - "A variety of nitinol-containing devices for transcatheter closure of atrial septal defects (ASD) has been widely used. " 04/01/2001 - "Transcatheter closure of secundum atrial septal defect with a new self-expanding nitinol double disk device (Amplatzer device): experience in Nanjing."
9.	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/01/2002 - "After surgical repair of the atrial septal defect, exhaled nitric oxide decreased by 21%, from 10.9 +/- 4.4 to 8.4 +/- 3.3 ppb (P <.005), whereas after transcatheter defect closure, exhaled nitric oxide increased by 23%, from 7.6 +/- 2.6 to 9.3 +/- 3.7 ppb (P <.005). " 10/01/2002 - "We measured nitric oxide levels in end-tidal expiratory gas with a rapid-response chemiluminescent analyzer before and after atrial septal defect closure. " 10/01/2002 - "Therefore we compared changes in exhaled nitric oxide levels after surgical and transcatheter device closure of atrial septal defects. " 10/01/2002 - "Levels of exhaled nitric oxide before and after surgical and transcatheter device closure of atrial septal defects in children." 02/01/2000 - "To determine the effect of pulmonary blood flow (Qp) on nitric oxide (NO) production in patients with increased Qp due to an atrial septal defect (ASD). "
10.	antineoplaston A10 (A 10)IBA 02/01/2000 - "The STARFlex system was effective in closing created atrial septal defects using a 10 Fr delivery sheath and low device/defect sizing ratios, comparing favorably with the standard CardioSEAL. " 10/01/1991 - "Cases with atrial septal defect have shown a significant association with A3 besides A10. " 01/01/2013 - "We reported a 10 month-old boy who has hypotonia, microcephaly, hypertelorism, depressed nasal bridge, epicanthic folds and bilateral multiple ear tags, high arched palate, down set ears, micrognathia and congenital heart disease such as patent ductus arteriosus (PDA), Atrial septal defect (ASD), mild pulmonary stenosis. " 04/01/1978 - "Serum glucose levels of six different patient groups were investigated preoperatively, during operation, postoperatively and in the first postoperative days: Group A, 10 cholecystectomy patients with 5% glucose infusion 2000 ml/day at a constant infusion rate; group B, 10 cholecystectomy patients with 10% constant rate glucose infusion; group C, 20 cholecystectomy or hernia patients with saline infusion; group D, 34 patients with 5% free rate glucose infusion 2000 ml/day; group E, 15 atrial septal defect patients with 5% constant rate glucose infusion 1500 ml/day and group f, 14 valvular surgery patients with 5% constant rate glucose infusion. "

Therapies and Procedures

1.	Septal Occluder Device 06/01/2000 - "The use of more than one Amplatzer septal occluder to close multiple atrial septal defects is safe and effective. " 08/01/2014 - "The immediate, 1-, and 5-year follow-up outcomes of the Continued Access clinical trial continue to demonstrate that the GORE HELEX Septal Occluder is a safe and effective transcatheter occluder for repair of ostium secundum atrial septal defect." 02/01/2012 - "Device closure of secundum atrial septal defects using Amplatzer Septal Occluder is safe and effective in the medium term. " 11/01/2003 - "The Helex septal occluder was safe and effective for occluding small to moderate atrial septal defects. " 12/01/2000 - "Transcatheter closure of large atrial septal defects with the Amplatzer Septal Occluder is feasible, safe and effective. "
2.	Sternotomy 03/01/1998 - "The xiphoid process window, with no median sternotomy, permitted closure of the atrial septal defects with good results and could be used as a less invasive technique for their correction." 12/01/2011 - "Standard surgical closure of an atrial septal defect via sternotomy is safe and effective. " 08/01/2003 - "Standard surgical closure of an atrial septal defect via sternotomy is a safe and effective procedure with low morbidity and mortality. " 03/01/1999 - "This study reviews the current method of atrial septal defect closure at our institute with a minimally invasive approach without median sternotomy. " 10/01/2015 - "Between May 2007 and November 2012, 26 patients underwent atrial septal defect closure with standard median sternotomy (Group 1). "
3.	Catheters 08/01/2015 - "Percutaneous transcatheter closure techniques and devices for congenital intracardiac shunts have considerably improved; therefore, catheter closure is now the treatment of choice for atrial septal defects (ASD). " 09/01/2014 - "Three-dimensional images provided improved imaging of devices and catheters and of the relationship between atrial septal defect devices and the aorta. " 03/01/2005 - "Echocardiographic guidance of catheter-based treatments of atrial septal defect: transesophageal echocardiography remains the gold standard." 05/01/2015 - "This study aimed to review the single institutional experience of the repair of secundum atrial septal defect (ASD) after the initiation of percutaneous trans-catheter device closure, to confirm the current management strategy and outcomes. " 01/01/2012 - "The study included 16 patients who underwent the catheter-based procedures to close an atrial septal defect between February 2008 and December 2011 at the Paediatrics Clinic, CCU Sarajevo, after clinical and TTE and TEE evaluation. "
4.	Thoracotomy 10/20/2015 - "To compare the outcomes of totally thoracoscopic technique (TTS) vs. right anterolateral thoracotomy technique (RALT) in female patients undergoing minimal invasive atrial septal defect (ASD) correction. " 10/20/2015 - "Two Different Minimally Invasive Techniques for Female Patients with Atrial Septal Defects: Totally Thoracoscopic Technique and Right Anterolateral Thoracotomy Technique." 10/01/2015 - "This group was compared with 21 patients who underwent repair of atrial septal defects using minimal right vertical infra-axillary thoracotomy (Group 2). " 09/01/2015 - "From December 2002 to July 2010, 25 female patients with a mean age of 8.5 ± 1.3 years underwent repair of atrial septal defects with a right anterolateral thoracotomy. " 09/01/2015 - "Right Anterolateral Thoracotomy in the Repair of Atrial Septal Defect: Effect on Breast Development."
5.	Stents 12/01/2015 - "Handling the stents in ductus, right ventricle and atrial septal defect was straightforward. " 12/01/2015 - "Eleven stents in right ventricle, four ones in atrial septal defect, two in right pulmonary artery, seven in the left pulmonary artery and two in inferior vena cava were completely removed. " 12/01/2015 - "Stents were previously deployed in: ductus (6), right ventricle outflow tract (12), atrial septal defect (4), right pulmonary artery (4), left pulmonary artery (16), inferior vena cava (2), superior vena cava (1) and ascending aorta (1). " 06/01/2014 - "The findings showed a breach of the physiologic criteria for interstage monitoring in seven infants (50 %) after 10 days (range 4-68 days) (five hybrid and two Norwood patients), leading to rehospitalization and catheterization for six patients (four hybrid and two Norwood patients), requiring interventions for two patients (patent arterial duct stent dilation, and atrial septal defect stenting, all for hybrid patients). " 12/01/2007 - "On day 48 of life, she was submitted to stent placement (6 mm) within the atrial septum to treat a restrictive atrial septal defect. "