Heart Rupture

Disease-related laceration or tearing of tissues of the heart, including the free-wall MYOCARDIUM; HEART SEPTUM; PAPILLARY MUSCLES; CHORDAE TENDINEAE; and any of the HEART VALVES. Pathological rupture usually results from myocardial infarction (HEART RUPTURE, POST-INFARCTION).

Also Known As:

Networked: 235 relevant articles (11 outcomes, 15 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infarction
2.	Cardiogenic Shock
3.	Cardiac Tamponade
4.	Pulmonary Edema
5.	Myocardial Infarction

Experts

1.	Ingemansson, Richard: 8 articles (04/2015 - 09/2009)
2.	Lindstedt, Sandra: 7 articles (04/2015 - 01/2011)
3.	Malmsjö, Malin: 7 articles (04/2015 - 09/2009)
4.	Gao, Xiao-Ming: 7 articles (01/2013 - 10/2002)
5.	Du, Xiao-Jun: 7 articles (01/2013 - 10/2002)
6.	Dart, Anthony M: 5 articles (01/2013 - 10/2002)
7.	Anzai, Toshihisa: 5 articles (01/2013 - 01/2003)
8.	Cavasin, Maria A: 5 articles (05/2006 - 05/2003)
9.	Heymans, Stephane: 4 articles (12/2011 - 09/2004)
10.	Maekawa, Yuichiro: 4 articles (12/2010 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Heart Rupture:

1.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 07/01/2002 - "This case suggests that percutaneous intrapericardial fibrin-glue fixation therapy is an effective treatment for the oozing type of left ventricular free wall rupture and that there is no risk of left ventricular restriction during long-term follow-up." 09/01/2002 - "[Surgical repair of left ventricular free wall rupture using layered fibrin glue sheet and fibrin glue; report of a case]." 07/01/2002 - "This report describes a long-term survival case of left ventricular free wall rupture treated with percutaneous intrapericardial fibrin-glue fixation therapy. " 07/01/2002 - "Long-term usefulness of percutaneous intrapericardial fibrin-glue fixation therapy for oozing type of left ventricular free wall rupture: a case report." 04/01/2000 - "Oozing type cardiac rupture repaired with percutaneous injection of fibrin-glue into the pericardial space: case report."
2.	DobutamineFDA LinkGeneric 12/01/1990 - "Hemodynamic efficacy of rapid saline infusion and dobutamine versus saline infusion alone in a model of cardiac rupture." 02/15/2005 - "We report one case of cardiac rupture during contrast-enhanced dobutamine stress echocardiography." 02/15/2005 - "Cardiac rupture during contrast-enhanced dobutamine stress echocardiography." 03/01/2002 - "[Left ventricular free wall rupture during dobutamine stress echocardiography]." 04/01/1998 - "Cardiac rupture during dobutamine stress test."
3.	CollagenIBA 11/01/2007 - "Our study illustrates the breakdown of fibril collagen as a central mechanism of cardiac rupture." 11/01/2015 - "Furthermore, lower collagen deposition in Girdin(SA/SA) mice impaired cardiac repair and resulted in increased mortality attributed to cardiac rupture. " 04/01/2015 - "This defect in neutrophil removal in turn caused enhanced matrix degradation, delayed collagen deposition and increased susceptibility to cardiac rupture. " 01/31/2014 - "In rescue experiments, the injection of PLA2R(+/+) myofibroblasts into the infarcted myocardium prevented post-MI cardiac rupture and reversed the decrease in collagen content in the infarcted region in PLA2R(-/-) mice. " 08/01/2008 - "We conclude that a higher collagen level is associated with facilitated fibrotic healing of an infarct and preserves the tensile strength of infarcted myocardium, thereby preventing cardiac rupture and acute ventricular remodelling."
4.	Tissue Inhibitor of Metalloproteinase-3IBA 05/01/2011 - "TIMP-3 deficiency resulted in a fourfold increase in cardiac rupture and 50% decrease in survival after MI. " 05/01/2011 - "Treatment with cetuximab significantly decreased the incidence of cardiac rupture and improved survival post-MI in TIMP-3(-/-) mice. " 05/01/2011 - "Deficiency in TIMP-3 increases cardiac rupture and mortality post-myocardial infarction via EGFR signaling: beneficial effects of cetuximab." 05/01/2011 - "This study investigated the role of tissue inhibitor of metalloproteinase-3 (TIMP-3)/matrix metalloproteinase (MMP)/epidermal growth factor (EGF)/transforming growth factor (TGF)-β1 pathway in infarct healing and effects of cetuximab on cardiac rupture after MI. " 05/01/2011 - "We conclude that deficiency in TIMP-3 increases cardiac rupture post-MI via EGF/epidermal growth factor receptor (EGFR) signaling which downregulates TGF-β1 expression and collagen synthesis. "
5.	cetuximab (Erbitux)FDA Link 05/01/2011 - "Inhibition of EGFR by cetuximab protects against cardiac rupture and improves survival post-MI." 05/01/2011 - "Treatment with cetuximab significantly decreased the incidence of cardiac rupture and improved survival post-MI in TIMP-3(-/-) mice. " 05/01/2011 - "Deficiency in TIMP-3 increases cardiac rupture and mortality post-myocardial infarction via EGFR signaling: beneficial effects of cetuximab." 05/01/2011 - "This study investigated the role of tissue inhibitor of metalloproteinase-3 (TIMP-3)/matrix metalloproteinase (MMP)/epidermal growth factor (EGF)/transforming growth factor (TGF)-β1 pathway in infarct healing and effects of cetuximab on cardiac rupture after MI. "
6.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 05/01/2010 - "It was also found that beta blockers and ACE inhibitors are variables providing protection against heart rupture. " 05/01/2010 - "Heart rupture is associated with older age, female gender, absence of previous infarct, and the administration of thrombolysis, while ACE inhibitors and beta blockers seem to prevent this complication." 05/01/2010 - "Heart rupture was associated with female gender, older age, the absence of previous infarct, and the administration of thrombolysis, while ACE inhibitors and beta blockers acted as protective variables. " 05/01/2010 - "A propensity score analysis was also performed to determine the involvement of beta blockers, ACE inhibitors, and fibrinolytics in the development of heart rupture. " 02/01/2008 - "Early administration of ACE inhibitors in unselected patients with acute MI should be considered standard therapy to reduce early deaths, specifically those due to cardiac rupture. "
7.	tachocombIBA 06/01/2005 - "Sutureless repair with TachoComb sheets for oozing type postinfarction cardiac rupture." 09/01/2002 - "This experience suggests that the layered TachoComb and fibrin glue are effective for left ventricular free wall rupture." 07/01/2005 - "A blow-out left ventricular free wall rupture (LVFWR) with an epicardial tear, 1 mm in diameter, was found, and sutureless repair with a collagen hemostat (TachoComb) was performed. " 06/01/2005 - "We present a case of oozing type postinfarction cardiac rupture that was treated successfully by a sutureless patch technique using a fibrin tissue-adhesive collagen fleece (TachoComb [Torii Pharmaceutical, Tokyo, Japan]). "
8.	Lisinopril (Prinivil)FDA LinkGeneric 02/01/2008 - "The improvement in survival associated with the lisinopril treatment was mainly due to a reduction in cardiac rupture, electromechanical dissociation, and pump failure occurring early (within 4 days) from the onset of MI symptoms. " 02/01/2008 - "The risk of dying from cardiac rupture was reduced by 39% by lisinopril treatment. "
9.	Cefotaxime (Kendrick)FDA LinkGeneric 01/01/1984 - "The patient improved after therapy with cefotaxime; however, cardiac rupture occurred on the sixth postoperative day. "
10.	liraglutideFDA Link 04/01/2009 - "Liraglutide reduced cardiac rupture (12 of 60 versus 46 of 60; P = 0.0001) and infarct size (21 +/- 2% versus 29 +/- 3%, P = 0.02) and improved cardiac output (12.4 +/- 0.6 versus 9.7 +/- 0.6 ml/min; P = 0.002). "

Therapies and Procedures

1.	Intra-Aortic Balloon Pumping 05/01/2000 - "We have consistently made it our strategy to attach percutaneous cardiopulmonary support system and intra-aortic balloon pumping immediately after the diagnosis regardless of the type of left ventricular free wall rupture and of the hemodynamic conditions, and perform an infarction-covering repair under the beating heart. " 07/01/1984 - "Our data indicate that improvement in mortality due to pulmonary edema and arrhythmias and reduction in incidence of cardiac rupture are evident effectiveness of the CCU, and that there is no improvement in survival rate of patients with cardiogenic shock even under the use of newly introduced vasodilator and catecholamine therapy or intraaortic balloon pumping."
2.	Thrombolytic Therapy 05/01/1996 - "Several clinical trials and overview analyses have suggested that the survival benefit conferred by thrombolytic therapy may be offset by a paradoxic increase in early deaths from cardiac rupture. " 04/01/1995 - "Cardiac rupture associated with thrombolytic therapy: impact of time to treatment in the Late Assessment of Thrombolytic Efficacy (LATE) study." 08/01/1990 - "Analysis of data from the Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI) trial independently confirmed the relation between time to thrombolytic therapy and risk of cardiac rupture (p = 0.03). " 10/01/1989 - "Thrombolytic therapy has been frequently reported to improve cardiac function and prognosis, but our study suggests that thrombolytic therapy must be evaluated moreover as one of the risk factors of cardiac rupture." 01/01/2013 - "No cases of external heart rupture were documented at autopsy whereas it was a cause of death in 39.1% of the patients given standard thrombolytic therapy. "
3.	Angioplasty (Angioplasty, Transluminal) 02/01/2002 - "Thus primary angioplasty (unlike systemic thrombolysis) seems to be able to prevent the postinfarction cardiac rupture. " 02/01/2002 - "Starting from these discouraging considerations, the finding is underscored that heart rupture only rarely occurs among patients treated with primary coronary angioplasty. " 04/01/2000 - "3) Inoadvanced elderly patients with reperfusion treatment, thrombolysis resulted in a higher mortality (17% vs. 7%) compared to direct angioplasty, probably due to increased incidence of cardiac rupture and pump failure in this age group. " 01/01/1998 - "The occurrence of double cardiac rupture (DCR) after a successful direct infarct coronary angioplasty (DICA) is extremely uncommon. " 01/01/1998 - "Double cardiac rupture after direct infarct coronary angioplasty: report of a case."
4.	Cardiopulmonary Bypass (Heart-Lung Bypass) 03/01/2012 - "All the cases with multiple cardiac rupture needed cardiopulmonary bypass or percutaneous cardiopulmonary support (PCPS) for their surgeries. " 11/01/1993 - "Surgical closure of cardiac rupture was performed in twelve patients under cardiopulmonary bypass (CPB). " 07/01/1981 - "This led to surgical exploration and to the repair of a cardiac rupture under cardiopulmonary bypass. " 03/01/2014 - "We report three cases of left ventricular free wall rupture (LVFWR) after acute myocardial infarction, which were repaired using a sutureless technique without cardiopulmonary bypass. " 02/01/2002 - "Under the cardiopulmonary bypass, we safely repaired the tracheal laceration and cardiac rupture."
5.	Negative-Pressure Wound Therapy 04/01/2015 - "Right ventricular heart rupture is a devastating complication associated with negative pressure wound therapy (NPWT) in cardiac surgery. " 10/01/2011 - "Right ventricular heart rupture is a devastating complication associated with negative pressure wound therapy (NPWT) following cardiac surgery. " 10/01/2011 - "Effects on drainage of the mediastinum and pleura during negative pressure wound therapy when using a rigid barrier to prevent heart rupture." 08/01/2011 - "Right ventricular heart rupture is a devastating complication associated with negative pressure wound therapy (NPWT) in cardiac surgery. " 08/01/2011 - "Haemodynamic effects of negative pressure wound therapy when using a rigid barrier to prevent heart rupture."