Heart Rupture

Disease-related laceration or tearing of tissues of the heart, including the free-wall MYOCARDIUM; HEART SEPTUM; PAPILLARY MUSCLES; CHORDAE TENDINEAE; and any of the HEART VALVES. Pathological rupture usually results from myocardial infarction (HEART RUPTURE, POST-INFARCTION).

Also Known As:

Networked: 421 relevant articles (25 outcomes, 24 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Myocardial Infarction
2.	Infarction (Infarctions)
3.	Rupture
4.	Cardiogenic Shock
5.	Cardiac Tamponade

Experts

1.	Ingemansson, Richard: 9 articles (04/2015 - 02/2009)
2.	Du, Xiao-Jun: 8 articles (04/2017 - 10/2002)
3.	Gao, Xiao-Ming: 8 articles (04/2017 - 10/2002)
4.	Lindstedt, Sandra: 8 articles (04/2015 - 02/2009)
5.	Malmsjö, Malin: 8 articles (04/2015 - 02/2009)
6.	Yang, Xiao-Ping: 7 articles (08/2019 - 05/2003)
7.	Dart, Anthony M: 6 articles (04/2017 - 10/2002)
8.	Anzai, Toshihisa: 5 articles (01/2013 - 01/2003)
9.	Cavasin, Maria A: 5 articles (05/2006 - 05/2003)
10.	Nie, Shaoping: 4 articles (10/2021 - 10/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Heart Rupture:

1.	CollagenIBA 01/01/2021 - "The appropriate production of collagen is beneficial for preserving the structural integrity of the heart, and protects the heart from cardiac rupture. " 11/01/2007 - "Our study illustrates the breakdown of fibril collagen as a central mechanism of cardiac rupture." 09/09/2023 - "The global and fibroblast-specific ALKBH5-knockout mice both exhibited low survival rates along with poor collagen repair, impaired cardiac function, and cardiac rupture. " 01/01/2023 - "Cthrc1 deficiency aggravated cardiac function and reduced collagen deposition as well as increased mortality attributable to cardiac rupture after MI. " 11/15/2018 - "miR-144 KO mice had a lower incidence of acute cardiac rupture compared with WT littermates early after MI but there was impaired late remodeling, reflected by increased total cardiac collagen content and collagen cross-linkage associated with changes in Zeb1/LOX1 axis, and decreased left ventricular ejection fraction. "
2.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 01/01/2019 - "Acute left ventricular free wall rupture treated by percutaneous intra-pericardial fibrin-glue infusion." 09/01/2002 - "[Surgical repair of left ventricular free wall rupture using layered fibrin glue sheet and fibrin glue; report of a case]." 04/01/2000 - "Oozing type cardiac rupture repaired with percutaneous injection of fibrin-glue into the pericardial space: case report." 07/01/2002 - "This case suggests that percutaneous intrapericardial fibrin-glue fixation therapy is an effective treatment for the oozing type of left ventricular free wall rupture and that there is no risk of left ventricular restriction during long-term follow-up." 07/01/2002 - "This report describes a long-term survival case of left ventricular free wall rupture treated with percutaneous intrapericardial fibrin-glue fixation therapy. "
3.	DobutamineFDA LinkGeneric 12/01/1990 - "Hemodynamic efficacy of rapid saline infusion and dobutamine versus saline infusion alone in a model of cardiac rupture." 02/15/2005 - "We report one case of cardiac rupture during contrast-enhanced dobutamine stress echocardiography." 02/15/2005 - "Cardiac rupture during contrast-enhanced dobutamine stress echocardiography." 03/01/2002 - "[Left ventricular free wall rupture during dobutamine stress echocardiography]." 04/01/1998 - "Cardiac rupture during dobutamine stress test."
4.	Cetuximab (Erbitux)FDA Link 05/01/2011 - "Treatment with cetuximab significantly decreased the incidence of cardiac rupture and improved survival post-MI in TIMP-3(-/-) mice. " 05/01/2011 - "Inhibition of EGFR by cetuximab protects against cardiac rupture and improves survival post-MI." 05/01/2011 - "Deficiency in TIMP-3 increases cardiac rupture and mortality post-myocardial infarction via EGFR signaling: beneficial effects of cetuximab." 05/01/2011 - "This study investigated the role of tissue inhibitor of metalloproteinase-3 (TIMP-3)/matrix metalloproteinase (MMP)/epidermal growth factor (EGF)/transforming growth factor (TGF)-β1 pathway in infarct healing and effects of cetuximab on cardiac rupture after MI. "
5.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 05/01/2010 - "It was also found that beta blockers and ACE inhibitors are variables providing protection against heart rupture. " 05/01/2010 - "A propensity score analysis was also performed to determine the involvement of beta blockers, ACE inhibitors, and fibrinolytics in the development of heart rupture. " 02/01/2008 - "Early administration of ACE inhibitors in unselected patients with acute MI should be considered standard therapy to reduce early deaths, specifically those due to cardiac rupture. " 05/01/2010 - "Heart rupture is associated with older age, female gender, absence of previous infarct, and the administration of thrombolysis, while ACE inhibitors and beta blockers seem to prevent this complication." 05/01/2010 - "Heart rupture was associated with female gender, older age, the absence of previous infarct, and the administration of thrombolysis, while ACE inhibitors and beta blockers acted as protective variables. "
6.	CatecholaminesIBA 11/01/1972 - "[Catecholamine concentration in different parts of the heart following myocardial infarct complicated by cardiac rupture]." 06/01/2007 - "The article concludes that: the LV functional disorder in takotsubo cardiomyopathy may be caused by distracted foci of coagulation and contraction band necrosis in the myocardium; contraction band necrosis (a sign of catecholamine cardiotoxicity) may reflect the sympathetic hyperactivity in this disease; persistent myocardial damage expressed by persistent ST-segment elevation without an electrocardiographic time evolution should be carefully observed with sequential echocardiographic examinations because of the possibility of cardiac rupture." 07/01/1984 - "Our data indicate that improvement in mortality due to pulmonary edema and arrhythmias and reduction in incidence of cardiac rupture are evident effectiveness of the CCU, and that there is no improvement in survival rate of patients with cardiogenic shock even under the use of newly introduced vasodilator and catecholamine therapy or intraaortic balloon pumping." 01/01/1989 - "The possible mechanisms of the benefit of beta-blockade in the prevention of cardiac damage are (a) reduction in the myocardial oxygen requirement by slowing the heart rate and lowering blood pressure and the velocity of left ventricular contraction, (b) reduction of infarct size, (c) prevention of catecholamine-induced myocardial necrosis, (d) prevention of catecholamine-induced life-threatening arrhythmias, (e) prevention of cardiac rupture, and (f) prevention of atheromatous plaque formation and rupture by reduction of arterial flow disturbance and wall stress. "
7.	tachocombIBA 06/01/2005 - "Sutureless repair with TachoComb sheets for oozing type postinfarction cardiac rupture." 09/01/2002 - "This experience suggests that the layered TachoComb and fibrin glue are effective for left ventricular free wall rupture." 01/01/2019 - "Sutureless repair using TachoComb/TachoSil patches can be a viable treatment option for left ventricular free wall rupture. " 07/01/2005 - "A blow-out left ventricular free wall rupture (LVFWR) with an epicardial tear, 1 mm in diameter, was found, and sutureless repair with a collagen hemostat (TachoComb) was performed. " 06/01/2005 - "We present a case of oozing type postinfarction cardiac rupture that was treated successfully by a sutureless patch technique using a fibrin tissue-adhesive collagen fleece (TachoComb [Torii Pharmaceutical, Tokyo, Japan]). "
8.	Glycoproteins (Glycoprotein)IBA 01/01/2022 - "Glycoprotein IIb/IIIa inhibitors are beneficial in preventing heart rupture, and the use of IABP in early PPCI is also helpful in preventing heart rupture." 05/01/2002 - "A subacute left ventricular free wall rupture after thrombolytic and glycoprotein IIb/IIIa inhibitor treatment: an overlooked finding of left ventriculography." 05/01/2002 - "We report a case of subacute cardiac rupture with frank pericardial effusion receiving thrombolytic and glycoprotein IIb/IIIa inhibitor therapies." 06/01/2001 - "The effect of antiplatelet therapy with glycoprotein IIb-IIIa receptor blockers (abciximab) on cardiac rupture is unknown. "
9.	goralatideIBA 08/01/2019 - "Thus, Ac-SDKP decreased cardiac rupture, ameliorated adverse cardiac remodeling, and improved cardiac function after MI, likely through preserved SERCA2 expression and inhibition of endoplasmic reticulum stress." 01/01/2018 - "Ac-SDKP prevents cardiac rupture and decreases mortality post-acute MI. " 01/01/2018 - "In infarcted mice, Ac-SDKP significantly decreased cardiac rupture incidence from 51.0% (26 of 51 animals) to 27.3% (12 of 44) and mortality from 56.9% (29 of 51) to 31.8% (14 of 44). " 01/01/2006 - "Ac-SDKP also reduced cardiac rupture rate in mice post-MI. " 01/01/2018 - "Ac-SDKP decreases mortality and cardiac rupture after acute myocardial infarction."
10.	Vasodilator Agents (Vasodilators)IBA 09/01/1987 - "[A change in the cause of death in myocardial infarction and the beneficial effect of vasodilator therapy on cardiac rupture following myocardial infarction]." 07/01/1984 - "Our data indicate that improvement in mortality due to pulmonary edema and arrhythmias and reduction in incidence of cardiac rupture are evident effectiveness of the CCU, and that there is no improvement in survival rate of patients with cardiogenic shock even under the use of newly introduced vasodilator and catecholamine therapy or intraaortic balloon pumping."

Therapies and Procedures

1.	Therapeutics 09/01/2016 - "Since the natural history includes a high incidence of cardiac rupture and mortality in the 30-45% range within the first year after diagnosis, surgical repair has been the main therapy. " 09/01/2014 - "Thus, the use of Tβ4 could be explored as an alternative therapy in preventing cardiac rupture and restoring cardiac function in patients with MI. " 11/27/2009 - "This case demonstrates that left ventricular free wall rupture is not always fatal and that early diagnosis and emergency surgical therapy may be successful. " 02/01/2009 - "Furthermore, there have been reports of cardiac rupture during -125 mmHg negative pressure therapy. " 12/16/2008 - "The decline in the incidence in cardiac rupture and its rate of death over the last 30 years appears to be associated with the increasing use of reperfusion strategies and adjunct medical therapy."
2.	Percutaneous Coronary Intervention 01/01/2006 - "Further studies are required to clarify the risk and benefit of tPA administration before percutaneous coronary intervention and the necessity of the emergency correction of AS to prevent cardiac rupture." 04/01/2022 - "In percutaneous coronary intervention (PCI) era, more clinically valuable risk factors are still needed to determine the occurrence of cardiac rupture (CR). " 01/01/2020 - "Patients with cardiac rupture were more likely to be female, with more advanced age, lower rate of primary percutaneous coronary intervention (PPCI), and higher in-hospital mortality. " 03/01/2021 - "Transesophageal Echocardiographic Diagnosis of Cardiac Rupture During Extracorporeal Membrane Oxygenation-Assisted Percutaneous Coronary Intervention." 06/01/2006 - "The case of a 73-year-old female with an acute myocardial infarction, treated successfully with primary percutaneous coronary intervention who developed subacute left ventricular free wall rupture, is presented. "
3.	Cardiopulmonary Resuscitation (CPR) 09/01/2019 - "Furthermore, the possibility of cardiac rupture induced by cardiopulmonary resuscitation should also be discriminated in such cases." 11/01/2017 - "Extracorporeal cardiopulmonary resuscitation for blunt cardiac rupture." 01/01/2000 - "Even though CPR-related cardiac rupture is rare, emergency medical staff should be aware of this complication." 01/01/2000 - "Cardiac rupture by penetration of fractured sternum: a rare complication of cardiopulmonary resuscitation." 02/01/1997 - "Another patient underwent repair of cardiac rupture following manual cardiopulmonary resuscitation. "
4.	Extracorporeal Membrane Oxygenation 10/01/2009 - "Management of left ventricular free wall rupture under extracorporeal membrane oxygenation support." 03/01/2021 - "Transesophageal Echocardiographic Diagnosis of Cardiac Rupture During Extracorporeal Membrane Oxygenation-Assisted Percutaneous Coronary Intervention." 08/29/2020 - "Is preoperative extracorporeal membrane oxygenation effective for collapsed patients with left ventricular free wall rupture after myocardial infarction?" 05/30/2020 - "After tracheal intubation and mechanical assistance by venoarterial extracorporeal membrane oxygenation (VA-ECMO), the sudden onset of PEA appeared to be caused by cardiac tamponade due to a blowout-type left ventricular free wall rupture (BO-LVFWR) diagnosed by transthoracic echocardiography. " 01/01/2013 - "Extracorporeal life support in a severe blunt chest trauma with cardiac rupture."
5.	Sutures (Suture) 08/23/2023 - "This sutureless technique has the benefit of avoiding sutures in the fragile infarcted myocardium and might be effective for left ventricular free wall rupture treatment." 12/01/2019 - "The double suture line avoids the risk of blood infiltrating behind the valve, into the AV groove, causing cardiac rupture. " 09/01/2007 - "We have performed a patch-and-glue technique, with or without direct suture and using cardioplegic arrest, to treat postinfarction cardiac rupture. " 09/01/2007 - "Patch-and-glue repair in combination with or without direct suture for cardiac rupture after myocardial infarction." 03/01/1977 - "In this method, the following advantages were observed: Improvement of cardiac functions, reduction of mortality, prevention of ventricular aneurysm, prevention of the occurrence of arrhythmias and ventricular fibrillation, minimum reduction of the intracardiac capacity and no suture dehiscence resulting in cardiac rupture. "