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Congenital Heart Defects (Congenital Heart Defect)

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Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.

Also Known As:

Congenital Heart Defect; Heart Defects, Congenital; Abnormality, Heart; Defects, Congenital Heart; Heart Defect, Congenital; Abnormalities, Heart; Defect, Congenital Heart; Heart Abnormality; Heart Abnormalities

Networked: 1340 relevant articles (28 outcomes, 109 trials/studies)

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Disease Context: Research Results

Related Diseases

1.	Heart Failure
2.	Pulmonary Hypertension (Ayerza Syndrome)
3.	Congenital Abnormalities (Deformity)
4.	Cardiomyopathies (Cardiomyopathy)
5.	Hypothermia

Experts

1.	Hobbs, Charlotte A: 9 articles (10/2011 - 01/2005)
2.	National Birth Defects Prevention Study: 8 articles (01/2016 - 04/2008)
3.	Bruneau, Benoit G: 8 articles (05/2012 - 03/2002)
4.	Cleves, Mario A: 8 articles (02/2011 - 01/2005)
5.	Steegers-Theunissen, Régine P M: 7 articles (09/2014 - 12/2006)
6.	Botto, Lorenzo D: 6 articles (01/2016 - 08/2003)
7.	Gaynor, J William: 6 articles (12/2014 - 01/2002)
8.	Correa, Adolfo: 6 articles (09/2014 - 07/2010)
9.	Stiller, Brigitte: 6 articles (12/2011 - 03/2004)
10.	Berger, Felix: 6 articles (12/2011 - 08/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Congenital Heart Defects:

1.	Idiopathic pulmonary hypertensionIBA 05/01/2012 - "Lung neovascularity in pulmonary arterial hypertension associated with congenital heart defects and idiopathic pulmonary arterial hypertension: study of 198 patients." 06/01/2015 - "Pulmonary arterial hypertension in congenital heart defects with left-to-right shunt." 07/01/2014 - "Pulmonary arterial hypertension is a common complication of congenital heart defects with left-to-right shunts. " 04/01/2014 - "In contrast with this, right chamber is pathologically an active part in severe pulmonary arterial hypertension (PAH) associated with congenital heart defects and also importantly influences its course and prognosis. " 10/01/2013 - "Pulmonary arterial hypertension (PAH) is one of the most severe complications of congenital heart defects with left to right shunt. "
2.	Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/01/2014 - "Previous studies suggest a possible association between maternal use of selective serotonin-reuptake inhibitors (SSRIs) during early pregnancy and congenital heart defects (CHD). " 11/01/2015 - "Evidence of an association between early pregnancy exposure to selective serotonin reuptake inhibitors (SSRI) and congenital heart defects (CHD) has contributed to recommendations to weigh benefits and risks carefully. " 05/01/2015 - "Selective Serotonin Reuptake Inhibitors (SSRIs) and the Risk of Congenital Heart Defects: A Meta-Analysis of Prospective Cohort Studies." 01/01/2014 - "Increased risk of severe congenital heart defects in offspring exposed to selective serotonin-reuptake inhibitors in early pregnancy--an epidemiological study using validated EUROCAT data." 11/01/2015 - "Major studies in 2014 and the first half of 2015 suggest that selective serotonin reuptake inhibitors are not strongly associated with congenital heart defects, that paroxetine 7.5 mg is effective for treating menopausal symptoms, and that women with heart failure may benefit more from cardiac resynchronization therapy than men. "
3.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 03/01/2015 - "The reported yield of congenital heart defects detection during the mid-gestational routine obstetrical screening has improved over time and detection rates up to 85% of major congenital heart defects have been reported when outflow tract and three-vessel views are included in conjunction with the four-chamber view. " 01/01/2010 - "To evaluate the effectiveness of the complete three-vessel view (c3VV) in assessment of fetuses with prenatally diagnosed congenital heart defects (CHD). " 01/01/2010 - "The complete three-vessel view in prenatal detection of congenital heart defects." 08/01/2009 - "In surgical reconstructions for congenital heart defects, vessel and anastomotic site patency is critical to success. " 08/01/2002 - "In 43 children with PVD due to congenital heart defects and 12 control subjects, pulmonary arterial pulsatility (the relative increase in vessel area during the cardiac cycle) and distensibility (the inverse of the stress/strain elastic modulus) were determined with intravascular ultrasound. "
4.	Paroxetine (Paxil)FDA LinkGeneric 02/01/2010 - "First-trimester use of paroxetine and congenital heart defects: a population-based case-control study." 01/01/2014 - "This article reports a newborn, whose mother used paroxetine during pregnancy, presenting with multiple congenital heart defects associated to typical physical characteristics of Treacher Collins syndrome." 01/01/2014 - "Treacher Collins syndrome with multiple congenital heart defects after paroxetine exposure: case report." 10/01/2010 - "An association between use of paroxetine and congenital heart defects was verified and a similar effect on hypospadias was seen. " 11/01/2015 - "Major studies in 2014 and the first half of 2015 suggest that selective serotonin reuptake inhibitors are not strongly associated with congenital heart defects, that paroxetine 7.5 mg is effective for treating menopausal symptoms, and that women with heart failure may benefit more from cardiac resynchronization therapy than men. "
5.	CosmeticsIBA 11/01/2009 - "We demonstrate the safety and efficacy of ministernotomy for the correction of a range of congenital heart defects with improved cosmetic results." 01/01/2013 - "The RVAI surgical approach to simple congenital heart defects was a safe procedure and could be performed with excellent cosmetic and clinical outcomes. " 01/01/2009 - "We conclude that the right anterolateral minithoracotomy for correction of congenital heart defects offers superior cosmetic results without increasing morbidity or mortality rates and confers upon patients psychological and social satisfaction." 10/01/2005 - "The Port-Access (Heartport Inc, Redwood City, CA) technique for correction of acquired and congenital heart defects in adults produces superior cosmetic results without increasing perioperative morbidity. " 10/01/2004 - "Much more concern is recently paid to the cosmetics when simple congenital heart defect is repaired. "
6.	Fentanyl (Sublimaze)FDA LinkGeneric 12/01/2005 - "Plasma fentanyl levels were measured during five consecutive operations on neonates and infants undergoing repair of congenital heart defects. " 08/01/1989 - "The use of fentanyl by an incremental intravenous (IV) bolus technique was evaluated in eight pediatric patients (ages 4 months to 5 years, ASA III-IV) undergoing corrective surgery for congenital heart defects. " 12/01/1985 - "After repair of congenital heart defects, stress responses in the pulmonary circulation of fourteen infants produced by a brief endotracheal suctioning procedure were studied before and after fentanyl (25 micrograms/kg). " 05/01/1985 - "Pulmonary and systemic hemodynamic responses to fentanyl were studied in 12 infants after repair of congenital heart defects. " 09/01/2002 - "In conclusion, the safety and efficacy of sufentanil in patients undergoing repair of complex congenital heart defects was the same as fentanyl. "
7.	Epoprostenol (Prostacyclin)FDA LinkGeneric 11/01/1985 - "Prostacyclin may be of some use in the assessment of the reversibility of an elevated pulmonary vascular resistance when surgery for the underlying congenital heart defect is being contemplated." 04/13/1999 - "Long-term prostacyclin for pulmonary hypertension with associated congenital heart defects." 04/13/1999 - "Although long-term prostacyclin (PGI2) has been shown to improve hemodynamics, quality of life, and survival in patients with primary pulmonary hypertension, its use in patients with pulmonary hypertension (PHT) and associated congenital heart defects (CHD) has not been evaluated. " 07/01/2006 - "Heparin-induced thrombocytopenia type II in an infant with a congenital heart defect--anticoagulation during cardiopulmonary bypass with epoprostenol sodium and heparin." 08/01/2010 - "To investigate the mechanisms, we evaluated the biosynthesis of thromboxane (TX) A(2) and prostacyclin (PGI(2)) in four groups of infants, cross-classified as shown below, by measuring the urinary excretion levels of 11-dehydro-TXB(2) and 2,3-dinor-6-keto-PGF(1alpha): DS infants with a left-to-right shunt and PH (D-PH, n = 18), DS infants without congenital heart defect (D-C, n = 8), non-DS infants with a left-to-right shunt and PH (ND-PH, n = 12), and non-DS infants without congenital heart defect (ND-C, n = 22). "
8.	Sufentanil (Sufenta)FDA LinkGeneric 09/01/2002 - "In conclusion, the safety and efficacy of sufentanil in patients undergoing repair of complex congenital heart defects was the same as fentanyl. " 03/01/1987 - "The pharmacodynamic and pharmacokinetic profiles of high-dose sufentanil (15 micrograms/kg) and oxygen were determined in 20 infants and children undergoing repair of congenital heart defects. " 08/01/1989 - "[Sufentanil-N2O2/O2 or halothane-N2O/O2 anesthesia in surgery of infants and children with congenital heart defects. "
9.	Lysine (L-Lysine)FDA Link 06/01/2005 - "For the purpose of screening for congenital heart defects, we used endocardial painting with fluorescently labeled poly-L-lysine and imaged BABB-cleared hearts with a 5x objective up to a depth of 2 mm. Two-photon imaging of whole-mount specimens stained with Hoechst nuclear dye produced clear images all the way through stage 29 hearts without significant signal attenuation. " 07/01/2010 - "In this paper, we discussed the mechanism of histone lysine methylation related to congenital heart defect in order to provide a useful reference for researchers working in this area." 07/01/2010 - "[Research progress in modification of histone lysine methylation and congenital heart defect]." 05/01/2009 - "Specific local cardiovascular changes of Nepsilon-(carboxymethyl)lysine, vascular endothelial growth factor, and Smad2 in the developing embryos coincide with maternal diabetes-induced congenital heart defects."
10.	Ampicillin (Omnipen)FDA LinkGeneric 08/01/1972 - "[Experience in the use of ampicillin to prevent complications following surgery for congenital heart defects]." 01/01/1974 - "[Clearance of ampicillin in children with congenital heart defects and heart failure (author's transl)]."

Therapies and Procedures

1.	Cardiopulmonary Bypass (Heart-Lung Bypass) 04/01/2010 - "Improvements in peri- and postoperative surgical techniques have greatly improved outcomes for pediatric patients undergoing cardiopulmonary bypass (CPB) in the treatment of congenital heart defects (CHDs). " 01/01/2001 - "Advances in cardiopulmonary bypass and cardiac surgical techniques have tremendously improved the outlook for children born with congenital heart defects. " 01/01/2013 - "Salivary samples of 25 patients undergoing elective surgery for congenital heart defects with cardiopulmonary bypass and an age and gender matched control group of 25 healthy children were enrolled in the study. " 07/01/2009 - "This study investigates the effects of controlled reoxygenation cardiopulmonary bypass on oxidative stress, inflammatory response, and organ function in children undergoing repair of cyanotic congenital heart defects. " 12/01/2001 - "The aim of our study was to investigate myocardial lesions and systemic inflammatory response after cardiac surgery with cardiopulmonary bypass in children suffering from congenital heart defects. "
2.	Heart Transplantation (Grafting, Heart) 10/01/2011 - "Cardiac transplantation is a challenging operation, and even more so in children with complex congenital heart defects. " 01/01/2006 - "Orthotopic heart transplantation for congenital heart defects: anomalies of the systemic venous return." 10/01/1998 - "Heart transplantation in the pediatric age-group and for end-stage congenital heart defects." 10/01/1998 - "To review the outcome of cardiac transplantation undertaken in patients with congenital heart defects. " 10/01/1998 - "Cardiac transplantation for end-stage congenital heart defects: the Mayo Clinic experience. "
3.	Sternotomy 03/01/2008 - "The right anterior minithoracotomy incision is a safe and effective alternative to a median sternotomy for correction of congenital heart defects. " 02/01/2001 - "Ministernotomy is as safe and effective as a full sternotomy in the repair of simple congenital heart defects in older children and adults. " 12/01/2010 - "Aim of the study was to evaluate the safety and efficiency of the partial inferior sternotomy approach to repair various congenital heart defects. " 04/01/2007 - "Our study demonstrated that the minithoracotomy is a safe effective and technically viable alternative to a median sternotomy to correct selected simple congenital heart defects. " 02/01/2001 - "Ministernotomy versus full sternotomy in congenital heart defects: a prospective randomized study."
4.	Fontan Procedure (Fontan Operation) 08/01/2015 - "The Fontan procedure, the last of a series of operations performed in patients with congenital heart defects, offers improved exercise capacity compared to baseline function but is still reduced compared to healthy peers. " 07/01/2013 - "The Fontan procedure is used to treat various serious congenital heart defects. " 10/01/2010 - "Modifications of the Fontan procedure are applied to a wide range of complex congenital heart defects with single ventricle physiology. " 03/01/2010 - "The Fontan operation is a palliative surgical procedure performed on children, born with congenital heart defects that have yielded only a single functioning ventricle. " 01/01/2010 - "Between June 2007 and May 2009, 186 consecutive patients underwent off-pump bidirectional Glenn shunt for a variety of complex cyanotic congenital heart defects. "
5.	Anesthesia 06/01/2015 - "[Anesthesia in children and adolescents with congenital heart defects]." 10/01/2011 - "The Congenital Cardiac Anesthesia Society has partnered with the Society of Thoracic Surgeons Congenital Heart Surgery Database to develop a patient registry for patients with congenital heart defects in order to determine patient outcomes related to anesthesia in this high-risk population. " 03/01/1994 - "[Biologically active substances in patients with hypervolemic congenital heart defects undergoing general multicomponent anesthesia]." 08/01/1993 - "[Intradural anesthesia in a newborn infant with congenital heart defect. " 05/01/1984 - "[Anesthesia for surgery of congenital heart defects in children]."