Sensorineural Hearing Loss

Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round windows. These elements include the AUDITORY NERVE and its connections in the BRAINSTEM.

Also Known As:

Networked: 2162 relevant articles (126 outcomes, 262 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Tinnitus
2.	Vertigo (Positional Vertigo)
3.	Hearing Loss (Hearing Impairment)
4.	Meniere Disease (Menieres Disease)
5.	Facial Paralysis (Facial Palsy)

Experts

1.	Nakashima, Tsutomu: 19 articles (11/2013 - 11/2002)
2.	Shepherd, Robert K: 14 articles (11/2014 - 05/2005)
3.	Sone, Michihiko: 12 articles (11/2013 - 11/2002)
4.	Grolman, Wilko: 11 articles (01/2016 - 09/2010)
5.	Guan, Min-Xin: 11 articles (05/2010 - 01/2004)
6.	Nakagawa, Takayuki: 10 articles (01/2014 - 12/2006)
7.	Sugiura, Saiko: 10 articles (11/2013 - 01/2003)
8.	Dai, Pu: 10 articles (11/2013 - 02/2006)
9.	Teranishi, Masaaki: 10 articles (11/2013 - 03/2007)
10.	Lalwani, Anil K: 9 articles (09/2015 - 07/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sensorineural Hearing Loss:

1.	Dexamethasone (Maxidex)FDA LinkGeneric 01/09/2012 - "The average period between onset of sudden sensorineural hearing loss and initiation of intratympanic dexamethasone injection was significantly shorter (207 days) in the improved group than in the unchanged group (482 days) (P<0.001). " 08/01/2006 - "Intratympanic dexamethasone medication can be beneficial in treating patient with sudden sensorineural hearing loss. " 09/01/2015 - "Dose Effect of Intratympanic Dexamethasone for Idiopathic Sudden Sensorineural Hearing Loss: 24 mg/mL Is Superior to 10 mg/mL." 12/01/2010 - "To determine if intratympanic dexamethasone injection (ITDI) is an effective treatment for sudden sensorineural hearing loss (SSNHL) in patients that systemic steroid treatment has failed. " 08/01/2006 - "The purpose of this study was to evaluate the efficacy of intratympanic administration of dexamethasone (IT-DEX) treatment on sudden sensorineural hearing loss (SSNHL) patients with diabetes by comparing the results with intravenous administration of dexamethasone (IV-DEX) treatment. "
2.	SteroidsIBA 07/01/2010 - "Treatment in sudden sensorineural hearing loss is a contentious issue, today, oral steroids are the most common choice and considered the best treatment option, but the use of intratympanic steroids has become an attractive alternative, especially in cases when systemic therapy fails, or to avoid the side effects of the systemic use of steroids. " 09/01/1991 - "The use of immediate postoperative low dose steroids provides marked decrease in the motion sensitivity and elimination of the transient sensorineural hearing loss. " 10/01/2004 - "Sudden sensorineural hearing loss has been managed with transtympanic steroid delivery, and this appears to be beneficial for some patients who have failed to respond to oral steroids, or have medical contraindications to systemic steroids. " 01/01/2011 - "Are systemic oral steroids effective for sensorineural hearing loss in bullous myringitis? " 09/01/2005 - "Instillation of intratympanic steroids represents a safe and potentially effective treatment of sudden idiopathic sensorineural hearing loss."
3.	OxygenIBA 12/15/1999 - "We report the case of a 14-year-old girl with a large vestibular aqueduct (LVA) in whom hyperbaric oxygen (HBO) therapy was effective for the treatment of sensorineural hearing loss. " 10/01/2013 - "The objective of this study was to compare the efficacy of intratympanic steroid injection (ITS), hyperbaric oxygen (HBO), and combination therapy as salvage treatment in patients with sudden sensorineural hearing loss (SSNHL) after failure of systemic therapy. " 08/01/2006 - "The aim of this study was to investigate the efficacy of hyperbaric oxygen (HBO) therapy in idiopathic sudden sensorineural hearing loss (ISSHL) by comparing hearing gain and improvement rate in patients who have been placed on both HBO and medical treatment (MT) (37 patients), and patients who have received MT only (17 patients). " 05/01/2012 - "The efficacy of intratympanic steroid administration was examined in comparison with hyperbaric oxygen (HBO) therapy in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). " 12/01/2011 - "We aimed to compare the efficacy of hyperbaric oxygen, oral steroid, intratympanic steroid therapy and their combinations in idiopathic sudden sensorineural hearing loss patients. "
4.	MethylprednisoloneFDA LinkGeneric 10/01/2003 - "In preliminary studies, inner ear perfusion of methylprednisolone in patients with severe, profound sudden sensorineural hearing loss who fail to respond to standard treatment is beneficial, with improvement in hearing thresholds of 16 to 25 dB and dramatic improvement in speech discrimination scores. " 11/01/2013 - "The purpose of this study was to compare the efficacy of systemic steroid alone and combined with intratympanic methylprednisolone in the treatment of patients with idiopathic sudden sensorineural hearing loss. " 01/01/2011 - "Intratympanic methylprednisolone improves hearing function in refractory sudden sensorineural hearing loss: a control study." 10/01/2002 - "The aim of this study was to determine if high-dose delivery of methylprednisolone to the round window can improve hearing after the failure of conventional treatment for sudden sensorineural hearing loss (SSHL). " 01/01/1998 - "The value of methylprednisolone in the treatment of an experimental sensorineural hearing loss following drill-induced ossicular chain injury: a randomized, blinded study in guinea-pigs."
5.	Adrenal Cortex Hormones (Corticosteroids)IBA 02/01/2002 - "Although autoimmune sensorineural hearing loss can be effectively treated with corticosteroids, little is known about how these drugs affect cochlear function. " 03/01/2000 - "Therefore, in patients with sensorineural hearing loss on the last hearing ear, we recommend a therapeutic trial with corticosteroids." 10/01/2015 - "High-dose corticosteroids are currently recommended for idiopathic sudden sensorineural hearing loss (ISSNHL) treatment. " 01/01/2014 - "To investigate the therapeutic effect of topical corticosteroids injection and systemic application in the treatment of typing idiopathic sudden sensorineural hearing loss (ISSNHL). " 05/25/2011 - "Idiopathic sudden sensorineural hearing loss has been treated with oral corticosteroids for more than 30 years. "
6.	Cisplatin (Platino)FDA LinkGeneric 08/01/2007 - "Both cisplatin and radiation therapy were proven to induce sensorineural hearing loss, in this study with short-term follow-up. " 02/01/2000 - "Recent studies demonstrate that up to 30% of patients experience sensorineural hearing loss on multimodality therapy with cisplatin and radiation. " 11/01/2015 - "In addition to age and noise-induced damage, ototoxicity is a common cause of sensorineural hearing loss with chemotherapeutic agents, for example, cisplatin, being a major contributor. " 03/01/2013 - "Cisplatin may cause permanent cochlear damage by changing cochlear frequency selectivity and can lead to irreversible sensorineural hearing loss. " 01/01/2009 - "Animals receiving radiation or cis-platinum and radiation experienced permanent significant ABR shifts at all frequencies, with 33% of the animals experiencing complete unilateral sensorineural hearing loss at 2 or more frequencies in the ear receiving the full radiation dose (7075 cGy over 25 fractions) (P < .05, paired t test analysis). "
7.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 05/01/1989 - "The second patient, who was on maintenance haemodialysis, achieved a 40 dB improvement in sensorineural hearing loss within two weeks of adding cyclophosphamide to pre-existing corticosteroid therapy. " 12/01/1990 - "Cyclophosphamide was used in this study to define the contribution of the inflammatory response relative to direct cytopathic effects of guinea pig cytomegalovirus (GPCMV) in inducing sensorineural hearing loss in the guinea pig. " 09/01/1980 - "Sensorineural hearing loss was improved in five of the nine patients after control of the disease with prednisone and cyclophosphamide." 05/01/1989 - "The first patient showed complete recovery of a sensorineural hearing loss averaging 50 dB after ten months treatment with cyclophosphamide and high-dose prednisolone. " 05/01/2001 - "Medical therapy with corticosteroids and cyclophosphamide improved the clinical picture but were ineffective in improving the bilateral sensorineural hearing loss and the facial paralysis on the operated side. "
8.	Vasodilator Agents (Vasodilators)IBA 10/01/2010 - "Further randomized, double-blind, placebo-controlled trials are needed in order to define the efficacy and acceptability of vasodilators in the treatment of sudden sensorineural hearing loss." 10/01/2010 - "Randomized controlled trials about using vasodilators to treat sudden sensorineural hearing loss were included. " 02/01/2002 - "[Vasodilators for sudden sensorineural hearing loss: a systematic review of randomized controlled trials]." 10/01/2010 - "The evidence currently available does not support the use of vasodilators in the treatment of sudden sensorineural hearing loss. " 10/01/2010 - "To evaluate the efficacy and safety of vasodilators for sudden sensorineural hearing loss. "
9.	Prednisone (Sone)FDA LinkGeneric 11/01/2010 - "Following intratympanic therapy with prednisone, 16 patients (47%) reported complete recovery of sudden sensorineural hearing loss, with a pure tone average that returned within 25 dB; 11 patients (32.3%) showed improvement in hearing of more than 30 dB; 4 patients presented improvement in pure-tone average between 10 and 30 dB. " 07/01/2014 - "A prospective, multi-centered study of the treatment of idiopathic sudden sensorineural hearing loss with combination therapy versus high-dose prednisone alone: a 139 patient follow-up." 10/01/2011 - "Intratympanic steroid treatment as primary treatment for sudden sensorineural hearing loss appears equivalent to treatment with high-dose oral prednisone therapy. " 07/01/2001 - "To treat patients with sudden sensorineural hearing loss (SSNL) who failed oral prednisone therapy by using a round window membrane (RWM) microcatheter. " 05/25/2011 - "Among patients with idiopathic sudden sensorineural hearing loss, hearing level 2 months after treatment showed that intratympanic treatment was not inferior to oral prednisone treatment. "
10.	MagnesiumIBA 08/01/2004 - "Magnesium is a relatively safe and convenient adjunct to steroid treatment for enhancing the improvement in hearing, especially in the low-tone range, in patients with sudden sensorineural hearing loss." 07/01/2002 - "Magnesium: a new therapy for idiopathic sudden sensorineural hearing loss." 07/01/1999 - "A negative Rinne test result with a 256-Hz magnesium tuning fork proved to be the best test to separate far-advanced otosclerosis from sensorineural hearing loss of other causes. " 01/01/2011 - "Recent studies in noise-induced and idiopathic sensorineural hearing loss have suggested that magnesium supplementation may lessen both hearing loss and the severity of tinnitus in patients. " 08/01/2004 - "In a prospective, randomized, double-blind, placebo-controlled trial, 28 patients with idiopathic sudden sensorineural hearing loss were treated with either steroids and oral magnesium (study group) or steroids and a placebo (control group). "

Therapies and Procedures

1.	Cochlear Implantation 04/01/2000 - "Multielectrode cochlear implantation is the most effective treatment for profound sensorineural hearing loss. " 12/01/2013 - "Cochlear implantation is beneficial for elderly patients with severe-profound sensorineural hearing loss as demonstrated by long-term stability of function, with the caveat that some individuals may experience significant decreases in speech recognition over time. " 09/01/2011 - "Bilateral cochlear implantation is a safe and effective intervention for severe sensorineural hearing loss and is believed to be more effective than unilateral implantation. " 11/01/2009 - "Supported by improved diagnostic tools allowing more definitive diagnosis of profound sensorineural hearing loss in young children, cochlear implantation in children <12 months of age is now common. " 07/01/2013 - "Cochlear implantation (CI) has become the mainstay of treatment for children with severe-to-profound sensorineural hearing loss (SNHL). "
2.	Hearing Aids (Hearing Aid) 01/01/1987 - "These results indicate that a multichannel compression hearing aid can be very effective in some individuals with sensorineural hearing loss and is superior to a conventional hearing aid in most subjects." 04/01/2011 - "To assess whether an improvement in speech recognition conferred by Vibrant Soundbridge is more marked than that afforded by open-fit hearing aids in patients with sloping high frequency sensorineural hearing loss (SNHL). " 01/01/2013 - "The present study aims to generate high-quality preliminary evidence for the efficacy of working memory training for adult hearing aid users with mild-to-moderate sensorineural hearing loss who are existing hearing aid users. " 04/01/2011 - "The Esteem(®) device proved to offer beneficial results in subjects suffering from high frequency, severe bilateral sensorineural hearing loss (SNHL) and may be considered as an alternative procedure to conventional hearing aids (HAs) or electroacoustic stimulation (EAS) systems. " 07/01/2014 - "The aims of this study were to (i) evaluate the efficacy of phoneme discrimination training for hearing and cognitive abilities of adults aged 50 to 74 years with mild sensorineural hearing loss who were not users of hearing aids, and to (ii) determine participant compliance with a self-administered, computer-delivered, home- and game-based auditory training program. "
3.	Hyperbaric Oxygenation 10/01/2015 - "Hyperbaric oxygen therapy (HBOT) is a promising treatment in the management of idiopathic sudden sensorineural hearing loss (ISSNHL), but the specific mechanisms of HBOT in ISSNHL are still unclear. " 09/01/2014 - "This study aims to evaluate the clinical efficacy of hyperbaric oxygen therapy (HBO2) in the management of idiopathic sudden sensorineural hearing loss. " 06/01/2010 - "This study investigated the efficacy of hyperbaric oxygen therapy (HBOT) as a secondary treatment for patients with idiopathic sudden sensorineural hearing loss (ISSNHL) in the subacute and chronic phases. " 01/01/2015 - "To investigate the efficacy of hyperbaric oxygen therapy as a salvage treatment for patients with sudden sensorineural hearing loss (SSHL). " 05/01/2012 - "Efficacy of intratympanic steroid administration on idiopathic sudden sensorineural hearing loss in comparison with hyperbaric oxygen therapy."
4.	Catheters 02/01/2009 - "Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic therapy." 03/01/2012 - "To observe and compare the efficacy of intratympanic application of dexamethasone (DXM) for the treatment of refractory sudden sensorineural hearing loss (SSNHL), the DXM was given in three different ways: by tympanic membrane injection, by drip through a ventilation tube, and by perfusion through a round window catheter. " 02/01/2007 - "To investigate the efficacy of round window catheter placement with dexamethasone perfusion for 13 patients with intractable sudden sensorineural hearing loss (SSNHL). " 04/01/2005 - "Nine patients with sudden sensorineural hearing loss showed an improvement with intratympanic steroid therapy, consisting of MicroWick placement with dexamethasone drop (Decadron) administration for 1-2 weeks and/or round window catheter placement with steroid perfusion. " 02/01/2007 - "[Round window catheter placement with dexamethasone perfusion for intractable sudden sensorineural hearing loss]."
5.	Cochlear Implants (Cochlear Implant) 10/05/1999 - "Severe to profound sensorineural hearing loss can be effectively treated with cochlear implants. " 12/01/2002 - "Cochlear implants are a safe and effective treatment for children with severe to profound sensorineural hearing loss. " 01/01/2015 - "Cochlear implants (CIs) are currently the most promising intervention for improving hearing and speech in individuals with AN. Although previous studies have shown optimistic results, there was large variability concerning benefits of CIs among individuals with AN. The data indicate that different criteria are needed to evaluate the benefit of CIs in these children compared to those with sensorineural hearing loss. " 01/01/2013 - "Recently, several studies have shown that a cochlear implant is a suitable treatment for hearing rehabilitation of adults with unilateral sensorineural hearing loss (UHL), and benefits for speech comprehension in noise and localization have been demonstrated. " 12/01/2008 - "The aim of this study was to provide more information on the causes of sensorineural hearing loss (SNHL) in children cochlear implant candidates in Croatia. "