Halothane (Fluothane)

A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)

Also Known As:

Networked: 3222 relevant articles (77 outcomes, 252 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Bhardwaj, Anish: 10 articles (09/2008 - 06/2003)
2.	Hashimoto, Keitaro: 9 articles (08/2008 - 08/2002)
3.	Sugiyama, Atsushi: 8 articles (07/2015 - 08/2002)
4.	Bina, Saiid: 7 articles (03/2015 - 11/2002)
5.	Schuster, Frank: 7 articles (01/2014 - 06/2005)
6.	Anetseder, Martin: 7 articles (01/2013 - 08/2003)
7.	Roewer, Norbert: 7 articles (01/2013 - 08/2003)
8.	Toung, Thomas J K: 7 articles (07/2006 - 06/2003)
9.	Riazi, Sheila: 6 articles (09/2015 - 07/2010)
10.	Kraeva, Natalia: 5 articles (09/2015 - 07/2010)

Related Diseases

1.	Contracture 09/01/1990 - "The effect of varying temperatures on biopsies of skeletal muscle from these animals showed a marked decrease in contracture response to halothane when the muscle was cooled to 25 degrees C. " 09/01/1990 - "The rate of tension development of cooling-induced contractures in the absence or presence of halothane was significantly greater in denervated (2-90 days) than in innervated muscles. " 07/01/1987 - "The magnitude of contractures was, however, significantly greater in the dynamic than in the static halothane test for halothane concentrations less than 3%, but this did not influence diagnosis. " 04/01/2011 - "The aim of this study was to investigate whether these agents can be considered possible substitutes for halothane in a modified in-vitro contracture test. " 09/01/1989 - "The present study examines lipid profiles of human muscle (vastus lateralis) prior to halothane challenge, relating the lipid profiles to the magnitude of halothane contracture response in muscle from the same biopsy. "
2.	Malignant Hyperthermia 07/18/1998 - "The delayed onset of malignant hyperthermia after delivery of halothane is unusual and for successful treatment careful monitoring and rapid and aggressive therapy are needed." 08/01/1993 - "Metabolic response to halothane in piglets susceptible to malignant hyperthermia: an in vivo 31P-NMR study." 01/01/1991 - "[Malignant hyperthermia: halothane kinetics in a study model of muscular contraction. " 10/01/1990 - "In the present study cerebral blood flow (CBF) and spontaneous electroencephalogram (EEG) were recorded in 8 pigs susceptible (MHS) for the development of malignant hyperthermia and 8 non-susceptible pigs (nMHS) after exposure to 1% halothane. " 12/01/1983 - "The results of these studies do not support a use of halothane-induced aggregation of platelets to detect an abnormality in individuals susceptible to malignant hyperthermia, but do provide new evidence of the effects of halothane on cellular function."
3.	Ischemia 08/01/1997 - "In the current study, we investigate halothane effects on induction of perifocal SD-like depolarizations, CBF, and infarct evolution in focal ischemia. " 02/01/2002 - "Intraluminal focal ischemia was induced for 2 hours in 6 rats anesthetized with halothane and mechanically ventilated. " 12/01/1998 - "Recovery of cardiac function after ischemia was better in the 1% halothane group than in the control group but suppression on cardiac function inclined to increase concentration dependently. " 12/01/1998 - "Experimental group: Global ischemia was induced at the same time course as the control group and during reperfusion, halothane administered at the concentration of 1%, 2%, 3%. " 05/01/1998 - "Halothane-anesthetized rats were prepared for near-complete forebrain ischemia. "
4.	Cardiac Arrhythmias (Arrythmia) 01/01/1996 - "Two children in the halothane group developed cardiac dysrhythmia and were dropped from the study. " 04/01/1986 - "The incidence of arrhythmia with halothane in the Chinese population in this study was significantly higher than that reported previously in non-Chinese patients." 09/01/2004 - "Halothane may sometimes induce arrhythmia. " 08/01/2004 - "The persistence of respiratory RRI fluctuations under halothane might reflect reflex respiratory arrhythmia rather than efficient parasympathetic baroreflex activity." 03/01/1998 - "The effects of halothane on cardiac arrhythmias caused by abnormal automaticity are controversial, with either antiarrhythmic effects or enhancement of abnormal automaticity reported by different authors. "
5.	Hypothermia 07/01/1999 - "The modified FAWB was effective in minimizing the degree of hypothermia experienced in cats anesthetized with halothane for 90 minutes. " 05/01/1997 - "However, the final neurologic status and histopathology in both groups were worse than in the halothane-mild hypothermia or halothane-moderate hypothermia groups. " 11/01/1995 - "Although halothane and low CaCl2 both reduce intracellular Ca2+, contractile force, and metabolic demand, the better protective effect of halothane is not likely simply due to a reduction in contractile function and metabolic rate before or initially after hypothermia because these were reduced much more by low CaCl2 than by halothane." 11/01/1995 - "Halothane administered during hypothermia restores left ventricular pressure, cardiac efficiency, basal coronary flow, and flow responses better than low CaCl2. " 11/01/1995 - "During normothermic reperfusion after hypothermia, both concentrations of halothane protected better than low CaCl2. "

Related Drugs and Biologics

1.	Isoflurane
2.	Caffeine (No Doz)
3.	sevoflurane (Ultane)
4.	Enflurane (Ethrane)
5.	Antigens
6.	Antibodies
7.	Fentanyl (Sublimaze)
8.	Ethyl Ether (Ether)
9.	Proteins (Proteins, Gene)
10.	Oxygen

Related Therapies and Procedures

1.	Anesthesia
2.	Artificial Respiration (Mechanical Ventilation)
3.	Inhalation Anesthesia
4.	General Anesthesia
5.	Premedication