Haloperidol (Haldol)

A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)

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Networked: 5363 relevant articles (475 outcomes, 1001 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Citrome, Leslie: 23 articles (10/2014 - 02/2002)
2.	Lieberman, Jeffrey A: 22 articles (01/2013 - 02/2002)
3.	Leucht, Stefan: 20 articles (09/2022 - 03/2004)
4.	Kulkarni, Shrinivas K: 17 articles (02/2009 - 06/2002)
5.	Crespo-Facorro, Benedicto: 16 articles (01/2020 - 08/2006)
6.	Volavka, Jan: 16 articles (10/2014 - 02/2002)
7.	Czobor, Pal: 16 articles (07/2014 - 02/2002)
8.	Kane, John M: 15 articles (12/2015 - 05/2002)
9.	Devlin, John W: 13 articles (06/2021 - 04/2007)
10.	Bruera, Eduardo: 12 articles (12/2021 - 02/2010)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/1978 - "In the double blind study with haloperidol, both substances were found to be highly effective in the treatment of psychotic syndromes belonging predominantly to the schizophrenia group. " 01/01/2010 - "Treatment with RLAI is suggested to result in improved QALYs combined with cost savings compared with haloperidol LAI among the Swedish, high-risk non-compliant schizophrenia patient population. " 11/05/1997 - "It is as effective as haloperidol against the positive symptoms of schizophrenia, and more effective against negative symptoms, with significantly fewer extrapyramidal side-effects. " 10/31/2020 - "It might also be superior to haloperidol in inducing symptomatic remission in first episode schizophrenia. " 07/04/2006 - "Haloperidol is a prototype of typical APDs, and the other three drugs are atypical APDs, which are effective in reducing negative symptoms and cognitive deficits of schizophrenia, cause less side effects, and are more tolerable compared to haloperidol. "
2.	Delirium 11/01/2019 - "The AID-ICU trial is based on gold standard methodology applied to a large sample of clinically representative patients and will provide pivotal high-quality data on the benefits and harms of haloperidol for the treatment ICU-acquired delirium." 01/01/2017 - "These studies showed that short-term prophylactic administration of low-dose intravenous haloperidol significantly decreased the incidence of delirium in elderly patients admitted to intensive care units after non-cardiac surgery and in general intensive care unit patients with a high risk of delirium.However" 01/01/2016 - "Results from placebo-controlled prevention studies suggest a haloperidol-induced protective effect for delirium in older patients scheduled for surgery: two studies reported a significant reduction in ICU delirium incidence and one study found a significant reduction in delirium severity and duration. " 12/29/2022 - "Among patients in the ICU with delirium, treatment with haloperidol did not lead to a significantly greater number of days alive and out of the hospital at 90 days than placebo. " 05/01/2015 - "These results emphasize the need for more studies regarding the efficacy of haloperidol for treatment of delirium among older medical ICU patients and demonstrate the value of assessing nonintubated patients."
3.	Psychotic Disorders (Schizoaffective Disorder) 04/01/1997 - "The present study was undertaken with the aim to compare the efficacy of high and low oral doses of haloperidol in the treatment of acute and transient psychotic disorders. " 11/01/2010 - "Over the period of 1 week his oedema subsided, following which he was started on Haloperidol 5 mg/day, with which his psychosis improved significantly." 01/01/2017 - "To examine whether haloperidol alone is an effective treatment for psychosis-induced aggression or agitation, wherein clinicians are required to intervene to prevent harm to self and others. " 11/27/2016 - "To examine whether haloperidol alone, administered orally, intramuscularly or intravenously, is an effective treatment for long-term/persistent aggression in psychosis. " 11/14/2012 - "To investigate whether haloperidol alone, administered orally, intramuscularly or intravenously, is effective treatment for psychosis-induced agitation or aggression. "
4.	Catalepsy 01/01/2017 - "Compounds 43 and 51 demonstrated antagonistic activity according to the results of cAMP measurements (cAMP IC50 = 1.67 and 1.80 μM, respectively) and showed good efficacy in the haloperidol-induced catalepsy (HIC) rat model for PD at doses of up to 30 mg/kg. Further lead optimization based on a substructure searching strategy led to the discovery of compound 84 as an excellent A2A AR antagonist (A2A Ki = 54 nM, A2A/A1 fold < 0.1, cAMP IC50 = 0.3 μM) that exhibited significant improvement in anti-PD efficacy in the HIC rat model." 07/11/1985 - "Ablation of the frontal or parietal cortex led to a marked decrease in haloperidol catalepsy, whereas lesions of the occipital cortex, or of the olfactory bulbs did not affect catalepsy, when measured 3 weeks post lesion in all cases. " 02/15/2015 - "A significant reduction of the catalepsy response was seen in rats previously given haloperidol and receiving DBS at the IC. " 10/15/2008 - "In addition, compound 35 had good metabolic stability with a scaled intrinsic clearance of 3 mL/min/kg (HLM) and demonstrated efficacy in the haloperidol induced catalepsy model." 01/01/1993 - "In contrast, haloperidol was found to be more effective in inducing catalepsy after i.v. (ED50 = 0.4 mumol/kg) than after i.p. "
5.	Mania (Manias) 07/19/2006 - "There is some evidence that haloperidol is an effective treatment for acute mania. " 06/01/2009 - "Recent studies have demonstrated clear evidence on the efficacy of haloperidol on the treatment of acute mania. " 01/01/2013 - "In Europe, haloperidol is still the reference substance used in clinical trials despite the fact that it is not officially indicated in the treatment of mania. " 01/01/2005 - "It is paradoxical to note that, in Europe, haloperidol is still the reference substance used in clinical trials despite the fact that it is not officially indicated in the treatment of mania. " 08/01/2001 - "In this study, the authors examined the relationship between steady-state haloperidol blood levels and clinical response in patients with acute psychotic mania. "

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1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Injections
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5.	General Anesthesia