H-Y Antigen

A sex-specific cell surface antigen produced by the sex-determining gene of the Y chromosome in mammals. It causes syngeneic grafts from males to females to be rejected and interacts with somatic elements of the embryologic undifferentiated gonad to produce testicular organogenesis.

Also Known As:

Networked: 97 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fry, Terry J: 3 articles (01/2014 - 04/2009)
2.	Walsh, Meghaan P: 2 articles (01/2013 - 04/2009)
3.	Manjili, Masoud H: 2 articles (04/2011 - 03/2011)
4.	Yang, Arvin S: 2 articles (10/2003 - 05/2003)
5.	Lattime, Edmund C: 2 articles (10/2003 - 05/2003)
6.	Grąt, Michał: 1 article (01/2015)
7.	Zborowska, Hanna: 1 article (01/2015)
8.	Krasnodębski, Maciej: 1 article (01/2015)
9.	Lewandowski, Zbigniew: 1 article (01/2015)
10.	Ligocka, Joanna: 1 article (01/2015)

Related Diseases

1.	Gonadal Dysgenesis (Gonadal Agenesis) 04/15/1977 - "In the present article, we report positive results in the first case of 46,XY pure gonadal dysgenesis (Swyer's syndrome) to be typed for H-Y antigen. " 01/01/1981 - "These observations of genetic heterogeneity must be considered when interpreting studies in which individuals with XY gonadal dysgenesis may or may not show H-Y antigen." 04/01/1986 - "These findings suggest a relation between the tumorization potentiality of the gonadal remnants and the H-Y antigen levels in 46,XY pure gonadal dysgenesis." 06/01/1984 - "Absence of H-Y antigen in a case of sporadic pure gonadal dysgenesis." 01/01/1984 - "The authors describe a case they have personally seen of pure gonadal dysgenesis with caryotype 46 XY (Swyers' syndrome) in which they found absence of HY antigen. "
2.	Graves Disease (Basedow Disease) 01/03/1983 - "The H gene theory is superior to the linkage disequilibrium theory in that it accounts for all the known genetic features of Graves' disease, including the female sex preponderance, which is ascribed to the effect of clonal deletions imposed by the H-Y antigen."
3.	Neoplasms (Cancer) 04/01/1986 - "After resection of the tumors, H-Y antigen level became intermediate. " 04/01/1986 - "Three patients, after gonadal tumor ablation, had intermediate H-Y antigen levels. " 04/01/1986 - "Three patients, without gonadal tumor, had female H-Y antigen. " 07/01/1985 - "Since these tumors lack the Y chromosome (required for production of the H-Y antigen that is presumably obligatory for embryonic male sexual differentiation), identifiable male sex organ structures should not be found in the tumor. " 01/01/2014 - "To test this hypothesis, we utilized the clinically relevant male-specific antigen HY and studied the fate of adoptively transferred, HY-CD8(+) T cells (HY-CD8) against a HY-expressing epithelial tumor (MB49) and pre-B cell leukemia (HY-E2APBX ALL) in BMT recipients. "
4.	Ovotesticular Disorders of Sex Development 05/01/1987 - "When the study is done HY antigen is always increased in patients with true hermaphroditism and sometimes slightly increased in their mothers who are phenotypically normal." 01/01/1980 - "H-Y antigen expression in a case of XX true hermaphroditism." 12/01/1976 - "Presence of H-Y antigen and testis in 46, XX true hermaphroditism, evidence for Y-chromosomal function." 03/01/1985 - "A newly developed enzyme-linked immunosorbent assay (ELISA) has been applied to the study of H-Y antigen in cases of XY, XYY, and X,dicY gonadal dysgenesis, testicular feminization syndrome, XXXXY syndrome, and XX true hermaphroditism. " 07/01/1978 - "The status of H-Y antigen was studied in 10 intersexual cases (three pure gonadal dysgenesis with XY genotype, three Klinefelter's syndrome, two true hermaphroditism with XX genotype, two male hermaphroditism) and in 18 normal adult subjects (nine males and nine females). "
5.	Transsexualism 02/01/1986 - "Recent reports have implied that patients with transsexualism exhibit H-Y antigen phenotypes at variance with those of normal males and females and, thus, that H-Y serology might provide a tool for the diagnosis and study of the transsexual condition. " 01/15/1981 - "[Transsexualism and the H-Y antigen]." 01/01/1981 - "[H-Y antigen in gender dysphoria and transsexualism (author's transl)]." 01/01/1980 - "The relevance of H-Y antigen for the aetiology of transsexualism is discussed."

Related Drugs and Biologics

1.	Antigens
2.	Immunoglobulins (Immunoglobulin)
3.	Cyproterone Acetate
4.	Interleukin-10 (Interleukin 10)
5.	alpha-beta T-Cell Antigen Receptors (T-Cell Receptor alpha-Chain)
6.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
7.	Minor Histocompatibility Antigens
8.	Steroid 21-Hydroxylase (21 Hydroxylase)
9.	Sepharose (Agarose)
10.	Antigen Receptors (Antigen Receptor)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Liver Transplantation