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Gynatresia

Absence of a normal opening in the lumen of the female genital tract, from the FALLOPIAN TUBES to the VAGINA. This anomaly may be congenital or acquired due to injuries, diseases, or TISSUE ADHESIONS.

Also Known As:

Asherman's Syndrome; Intrauterine Synechiae; Uterine Synechiae; Ashermans Syndrome; Gynatresias; Syndrome, Asherman; Syndrome, Asherman's; Synechiae, Intrauterine; Synechiae, Uterine; Asherman Syndrome

Networked: 85 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Female Urogenital Diseases and Pregnancy Complications
- Female Urogenital Diseases
  - Female Genital Diseases: 236
    - Gynatresia: 85

Related Diseases

1.	Vaginitis
2.	Gynatresia
3.	Amenorrhea
4.	Wounds and Injuries (Trauma)
5.	Infertility (Sterility)

Experts

1.	Fernandez, Hervé: 4 articles (03/2013 - 09/2006)
2.	Cervelló, Irene: 2 articles (12/2015 - 09/2015)
3.	Santamaría, Xavier: 2 articles (12/2015 - 09/2015)
4.	Simón, Carlos: 2 articles (12/2015 - 09/2015)
5.	Singh, Neeta: 2 articles (04/2014 - 02/2010)
6.	Deffieux, Xavier: 2 articles (03/2013 - 10/2012)
7.	Ugburo, Andrew O: 2 articles (09/2012 - 10/2011)
8.	Fadeyibi, Idowu O: 2 articles (09/2012 - 10/2011)
9.	Oluwole, Ayodeji A: 2 articles (09/2012 - 10/2011)
10.	Mofikoya, Bolaji O: 2 articles (09/2012 - 10/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gynatresia:

1.	Hyaluronic Acid (Hyaluronan)IBA 10/01/2013 - "To compare the efficacy of intrauterine balloon, intrauterine contraceptive device and hyaluronic acid gel in the prevention of the adhesion reformation after hysteroscopic adhesiolysis for Asherman's syndrome. " 10/01/2013 - "A comparison of intrauterine balloon, intrauterine contraceptive device and hyaluronic acid gel in the prevention of adhesion reformation following hysteroscopic surgery for Asherman syndrome: a cohort study."
2.	Estrogens (Estrogen)FDA Link 08/01/2014 - "Stem cells, when added to estrogen, are a highly effective alternative to induce regeneration of endometrium in Asherman Syndrome therapy." 10/01/1985 - "It seems that in mild and moderate Asherman's syndrome, lysis of adhesions and IUD insertion without estrogen administration yield satisfactory results." 07/01/2014 - "We evaluated the outcome of treatment of uterine synechiae (or adhesions, also known as Asherman syndrome) by cervical dilatation and sequential estrogen and progestogen administration for three months. " 03/01/2010 - "Her FSH, estrogen, prolactin, TSH and T4 levels were normal, her B-HCG was negative, her BMI was 22 and she had no history of Asherman's syndrome. "
3.	Hereditary renal agenesisIBA 01/01/1964 - "[UNILATERAL RENAL AGENESIS ASSOCIATED WITH HOMOLATERAL GYNATRESIA AND DOUBLE UTERUS]." 01/01/2014 - "Herlyn-Werner-Wunderlich Syndrome results in a doubling of the internal genitalia accompanied by unilateral gynatresia (with hemi-hematokolpos, hemi-hematometra and/or hemi-hematosalpings) and ipsilateral renal agenesis. "
4.	Tamoxifen FDA LinkGeneric 08/09/2003 - "SCHS is indicated in case of abnormal uterine bleeding (premenopausal and postmenopausal), bleeding while using tamoxifen, suspicion of a congenital uterine abnormality and Asherman's syndrome. "
5.	ProlactinIBA 03/01/2010 - "Her FSH, estrogen, prolactin, TSH and T4 levels were normal, her B-HCG was negative, her BMI was 22 and she had no history of Asherman's syndrome. "
6.	PlasticsIBA 10/01/2011 - "Joint management by plastic surgeons and gynecologists using the pudendal thigh flap for vaginoplasty in caustic gynatresia resulted in a functional vagina. "
7.	Methotrexate (Mexate)FDA LinkGeneric 03/01/2013 - "Ultrasound-guided in situ methotrexate injection could be a nonsurgical alternative to terminate an intrauterine pregnancy after EA when the pregnancy is located within uterine synechiae, as shown by the second case. "
8.	Aprotinin (Trasylol)FDA Link 01/01/1974 - "[Prevention and therapy of Asherman's syndrome by proteinase inhibitor Trasylol]."
9.	Danazol (Azol)FDA LinkGeneric 01/01/1990 - "This procedure has been used with considerable success to reproduce the signs and symptoms of Asherman's syndrome when combined with pretreatment using the synthetic steroid Danocrine (danazol). "
10.	CopperIBA 04/01/2003 - "Intrauterine synechiae formation was prevented by copper T insertion and oral contraceptive pills. "

Therapies and Procedures

1.	Intrauterine Devices (Intrauterine Device) 11/01/2008 - "Efficiency and pregnancy outcome of serial intrauterine device-guided hysteroscopic adhesiolysis of intrauterine synechiae." 01/01/1990 - "[The use of the Medusa-type intrauterine contraceptive device in treating uterine synechiae in a woman with a bicornuate uterus. " 08/01/1988 - "[Surgical hysteroscopy in preventing the occurrence of Asherman's syndrome following the removal of intrauterine contraceptive devices]." 10/01/1985 - "Fifty-one women with only minimal and moderate intrauterine adhesions (Asherman's syndrome) underwent dilatation of the cervix, lysis of adhesions and insertion of intrauterine contraceptive devices (IUDs). " 02/15/1976 - "[The use of intrauterine contraceptive devices in the treatment and prevention of Asherman's syndrome]."
2.	Transplantation (Transplant Recipients) 01/01/2014 - "BMDSC transplantation is a potential novel treatment for Asherman's Syndrome and may also be useful to prevent Asherman's syndrome after uterine injury. " 01/01/2014 - "We evaluate stem cell recruitment and pregnancy after BMDSCs transplantation in a model of Asherman's syndrome. " 01/01/2014 - "Bone Marrow-Derived Stem Cell (BMDSC) transplantation improves fertility in a murine model of Asherman's syndrome."
3.	Aftercare (After-Treatment) 10/01/2012 - "To study the anatomic and fertility results after treatment for Asherman syndrome involving more than two separate surgical procedures. " 06/01/2015 - "To identify, by routine hysteroscopy, how many patients who were treated because of intrauterine pathology developed uterine synechiae within the first six months after treatment with monopolar resectoscope. " 09/01/2006 - "Fertility after treatment of Asherman's syndrome stage 3 and 4." 05/01/1990 - "Uterine rupture after treatment of Asherman's syndrome." 05/01/1989 - "Spontaneous uterine rupture during pregnancy after treatment of Asherman's syndrome."
4.	Sutures (Suture) 03/01/2011 - "This study suggests a significant risk of uterine synechiae after placement of compression sutures for PPH that transverse the uterine cavity. " 10/01/2014 - "[Risk of uterine synechiae following uterine compression sutures during postpartum haemorrhage]." 03/01/2011 - "Four women (26.7%) developed uterine synechiae and one had a subsequent pregnancy 18 months after uterine compression sutures. " 08/01/2010 - "In this report, we present a case of Asherman syndrome with complete obliteration of the uterine cavity after the B-Lynch suture." 03/01/2011 - "To determine with hysteroscopy or hysterosalpingogram the risk of uterine synechiae following uterine compression sutures for major postpartum haemorrhage (PPH) caused by uterine atony. "
5.	Tubal Sterilization (Tubal Ligation) 01/01/2005 - "Patients who showed tubal occlusion or Asherman Syndrome were excluded from the study. " 04/01/2011 - "A small proportion of patients may develop post-procedure intrauterine synechiae that impaired the ability to document tubal occlusion by hysterosalpingogram." 07/01/2007 - "Intrauterine synechiae do not appear to adversely affect the ability to perform HSG at 3 months or to document tubal occlusion."