Guanosine Triphosphate (GTP)

12/15/1992 - "Topical application of varying doses of GTP (1-24 mg) 30 min prior to that of each TPA application resulted in highly significant protection against skin tumor promotion in a dose-dependent manner. "
04/01/2013 - "In vivo efficacy studies showed that intravenously injected GTP-loaded LCPs triggered effective apoptosis of tumor cells, significant reduction of tumor cell proliferation and cell cycle progression, leading to dramatic inhibition of tumor growth, with little in vivo toxicity. "
01/01/2012 - "The results suggest that GTP treatment offers significant protection against 4-NQO induced lipid peroxidation and bone marrow toxicity and might be a promising potential candidate for prevention of mutations leading to cancer."
04/01/2011 - "Both GTP and BTP are effective in significantly inhibiting the cumulative number of mammary tumors (by ~92% and 77%, respectively) and in reducing their growth. "
07/01/2000 - "Total Ki-ras p21 and activated ras-GTP were not significantly greater in tumors than in normal lung or in tumors with versus those without Ki-ras mutations. "

11/01/1995 - "Topical application of GTP (1-6 mg/animal), 30 min prior to or 30 min after exposure to a single dose of UVB (2 kJ/m2) resulted in significant protection against local (25-90%) and systemic suppression (23-95%) of CHS and inflammation in mouse dorsal skin (70-80%). "
01/01/2011 - "GTP supplementation sustained microarchitecture and improved bone quality via a decrease in inflammation. "
06/01/2012 - "This study shows that GTP supplementation benefited body composition and bone properties in obese rats possibly through enhancing antioxidant capacity and suppressing inflammation."
01/01/2011 - "In conclusion, GTP supplementation mitigated deterioration of bone microarchitecture and improved bone integrity in rats with chronic inflammation by suppressing bone erosion and modulating cancellous and endocortical bone compartments, resulting in a larger net bone volume. "
01/01/2011 - "This study evaluated whether GTP can restore bone microstructure along with a molecular mechanism in rats with chronic inflammation. "

09/01/2015 - "Pregnant women were considered to be Torchs positive (Gtp) when they had positive results for at least one of these infections, and to be Torchs negative (Gtn) when they had negative results for all of them. "
10/30/1983 - "Second, a study of the kinetics of appearance of this activity, has demonstrated that the capacity to methylate GTP did not appear until 1 hr after infection and reached maximal levels by about 3 hr. Third, de novo protein synthesis was required. "
07/01/2015 - "contortus infections in lambs decreased meat quality, but appropriate levels of dietary GTP supplementation diminished these negative effects though lower dose of GTP supplement showed negative effects on digestion."
07/01/2015 - "contortus infections did not affect digestion but the apparent digestibilities of nutrients were decreased by dietary 2g of GTP/kg feed supplementation. "
01/01/2015 - "Levels of RhoA-GTP and ROCK1 activity were elevated upon ARV S1133 infection, while inhibition of RhoA and ROCK1 reduced autophagy and subsequent apoptosis. "

10/01/2010 - "Neither LPS administration nor GTP levels affected body weight and femoral bone area throughout the study period. "
01/01/2012 - "Supplementation of GTP in the drinking water in the HF+GTP group reduced body weight as compared to the HF group. "
07/01/2006 - "We found no correlation between the prevalence of GTP and body weight or length, femoral offset or size of the prosthetic components used."
12/01/2005 - "The administration of red meat significantly elevated T-Hg concentrations in the liver, kidney, erythrocytes, cerebral cortex and medulla oblongata from the control levels but did not elevate the T-Hg concentration in serum, showing the typical distribution pattern of M-Hg, not of inorganic Hg. The administration slightly but significantly increased GTP activity and P concentration and decreased BUN concentration in serum, although no abnormalities were observed in rat body weight gain and movement during the 7 days. "
11/01/2003 - "SCLN, IPLN, kidneys and IPAT weights in both sexes, spleen weight in males and body weight increase in males were significantly lower in GTP-fed mice. "

03/01/1997 - "GTP resulted in significant protection against the malignant conversion of papillomas to SCC in all the protocols employed. "
01/01/2011 - "Using a combination of genetically-modified mouse models that allow for the tissue-selective activation or deletion of signaling molecules and an activation-state sensitive Rac1 antibody that detects GTP-bound Rac1, we found that Rac1 contributes to K-Ras induced epidermal papilloma initiation and growth and that Rac1 activity is elevated by oncogenic K-Ras in vivo. "
11/01/1988 - "The K 1/2 for GTP activation of papilloma ODC was approximately 7 x 10(-9) M. "
12/01/1987 - "The two forms of papilloma OrnDCase differed in their sensitivities to heat inactivation and the ability of GTP to protect against heat inactivation. "
03/01/1997 - "The present study was designed to further evaluate the protective effect of GTP against the induction and subsequent progression of papillomas to squamous cell carcinomas (SCCs) in experimental protocols where papillomas were developed with a low or high probability of their malignant conversion. "