Guanosine Triphosphate (GTP)

12/15/1992 - "Topical application of varying doses of GTP (1-24 mg) 30 min prior to that of each TPA application resulted in highly significant protection against skin tumor promotion in a dose-dependent manner. "
04/01/2013 - "In vivo efficacy studies showed that intravenously injected GTP-loaded LCPs triggered effective apoptosis of tumor cells, significant reduction of tumor cell proliferation and cell cycle progression, leading to dramatic inhibition of tumor growth, with little in vivo toxicity. "
01/01/2012 - "The results suggest that GTP treatment offers significant protection against 4-NQO induced lipid peroxidation and bone marrow toxicity and might be a promising potential candidate for prevention of mutations leading to cancer."
04/01/2011 - "Both GTP and BTP are effective in significantly inhibiting the cumulative number of mammary tumors (by ~92% and 77%, respectively) and in reducing their growth. "
07/01/2000 - "Total Ki-ras p21 and activated ras-GTP were not significantly greater in tumors than in normal lung or in tumors with versus those without Ki-ras mutations. "

09/30/1993 - "In the case of lung tumorigenesis protocol, however, the protective effects of GTP were 41 and 39%, respectively. "
01/01/2007 - "The goal of this review is to provide the rationale, and discuss the use of EGCG in GTP as a chemopreventive agent for prevention of colon carcinogenesis and present evidence for the efficacy and safety of these agents based on epidemiological, animal, in vitro studies and Phase I clinical trials."
08/01/1991 - "In this study we assessed the effect of oral feeding and topical application of GTP on ultraviolet B (UVB) radiation-induced skin carcinogenesis in female SKH-1 hairless mice. "
01/01/2022 - "We demonstrate these fusions increase cellular levels of active GTP-RAS, induce cellular transformation, and promote in vivo tumorigenesis. "
01/01/2017 - "Nuclear HuR expression was not associated with any parameters such as carcinogenesis, muscle invasion, and GTP intake. "

10/01/2010 - "Neither LPS administration nor GTP levels affected body weight and femoral bone area throughout the study period. "
01/01/2023 - "Changes in AST, ALT, γ-GTP and body weight were significantly correlated with change in SWV. "
10/01/2022 - "Six-week young adult Wistar rats were fed with standard chow or HFD in the presence and absence of GTP (200 mg/kg body weight) for 18 weeks. "
03/01/2021 - "One hundred Holstein cows were assigned to GTP (0.2 g/kg DM; n = 50) or control (without GTP; n = 50) group based on body weight, previous milk yield, and parity on d 15 before expected parturition. "
07/01/2006 - "We found no correlation between the prevalence of GTP and body weight or length, femoral offset or size of the prosthetic components used."

11/01/1995 - "Topical application of GTP (1-6 mg/animal), 30 min prior to or 30 min after exposure to a single dose of UVB (2 kJ/m2) resulted in significant protection against local (25-90%) and systemic suppression (23-95%) of CHS and inflammation in mouse dorsal skin (70-80%). "
01/01/2011 - "GTP supplementation sustained microarchitecture and improved bone quality via a decrease in inflammation. "
01/01/2011 - "In conclusion, GTP supplementation mitigated deterioration of bone microarchitecture and improved bone integrity in rats with chronic inflammation by suppressing bone erosion and modulating cancellous and endocortical bone compartments, resulting in a larger net bone volume. "
01/01/2011 - "This study evaluated whether GTP can restore bone microstructure along with a molecular mechanism in rats with chronic inflammation. "
01/01/2021 - "These results indicate that LRRK2 is actively involved in proinflammatory responses in human lymphoblasts, and inhibition of GTP binding by 68 results in an anti-inflammation effect against proinflammatory stimuli. "

09/01/2015 - "Pregnant women were considered to be Torchs positive (Gtp) when they had positive results for at least one of these infections, and to be Torchs negative (Gtn) when they had negative results for all of them. "
12/20/2022 - "Thus, host cell reduction in GTP levels amplifies the nutritional stress to intracellular chlamydiae in infection-relevant models of persistence, illustrating the determinative role the infected host cell plays in bacterial stress responses. "
01/01/2019 - "This is the first report of concurrent infection of PPR and GTP in mixed flock of sheep and goats in Nigeria. "
12/01/2016 - "Furthermore, Arf6 is activated early during infection, with GTP-bound Arf6 localized to the R. "
07/01/2015 - "contortus infections in lambs decreased meat quality, but appropriate levels of dietary GTP supplementation diminished these negative effects though lower dose of GTP supplement showed negative effects on digestion."