Guanosine

A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)

Networked: 815 relevant articles (24 outcomes, 60 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rathbone, Michel P: 12 articles (01/2015 - 12/2003)
2.	Souza, Diogo O: 12 articles (04/2010 - 04/2004)
3.	Jiang, Shucui: 11 articles (02/2013 - 12/2003)
4.	Schmidt, André P: 10 articles (04/2010 - 04/2004)
5.	Ballerini, Patrizia: 9 articles (01/2015 - 11/2006)
6.	Souza, Diogo Onofre: 7 articles (12/2015 - 06/2002)
7.	D'Alimonte, Iolanda: 7 articles (01/2015 - 11/2006)
8.	Caciagli, Francesco: 7 articles (01/2015 - 12/2003)
9.	Ciccarelli, Renata: 6 articles (01/2015 - 12/2003)
10.	Rathbone, M P: 6 articles (07/2013 - 01/2000)

Related Diseases

1.	Infection 09/01/2014 - "A TLR9 inhibitory oligonucleotide containing five adjacent guanosine residues (G-ODN) exhibited virucidal activity and inhibited HSV-1 replication when added post-infection. " 07/01/2009 - "IDU, TFT) for the treatment of herpes simplex virus (HSV) infections; (vi) acyclic guanosine analogues (e.g. " 04/01/2002 - "Temporal pattern of herpes simplex virus type 1 infection and cell death in the mouse brain stem: influence of guanosine nucleoside analogues." 03/19/1995 - "In the early stage of virus infection, radio-detoxified endotoxin might bind to receptors of immature T cells and facilitate cell cycle through cyclic guanosine 3',5'-monophosphate stimulation. " 09/22/1993 - "The assay involves a heat inactivation step at 56 degrees C to prevent risk of infection, ultrafiltration as a pretreatment step prior to ion-pair reversed-phase liquid chromatography using guanosine as internal standard, and ultraviolet detection at 254 nm. This method has excellent recovery (97-100%), linearity (0.5-100 mg/l) and precision (1.2-8.0% coefficient of variation). "
2.	Ischemia 12/01/2015 - "Guanosine Protects Against Cortical Focal Ischemia. " 01/01/2014 - "Ischemia also affected glutamatergic parameters, illustrated by increased EAAC1 levels and decreased GLT1 levels; guanosine reversed the decreased GLT1 levels and did not affect the EAAC1 levels. " 01/01/2014 - "The potential therapeutic effect of guanosine after cortical focal ischemia in rats." 11/01/2001 - "Male C57 black mice (the "I" group of animals) underwent bilateral renal artery clamp for 32 minutes to induce ischemia and then received either normal saline ("NS") or guanosine ("G"). " 07/01/1993 - "Addition of the permeable analogue of guanosine 3',5'-cyclic monophosphate, 8-bromoguanosine 3',5'-cyclic monophosphate, improved reperfusion-induced intestinal blood flow significantly but did not provide protection against mucosal barrier disruption associated with the first hour of ischemia-reperfusion. "
3.	Anoxia (Hypoxia) 12/01/1997 - "Reoxygenation of the myocytes after 30 min of anoxia returned guanosine salvage rates to nearly normal (87% of control). " 12/01/1997 - "Anoxia inhibits guanosine salvage in cardiac myocytes." 10/01/1993 - "Hypoxia decreased guanosine 3',5'-cyclic monophosphate (cGMP) content 54 +/- 4% in all LPS and 33 +/- 4% in the non-LPS intact rings (P < 0.05). " 05/01/1992 - "Our laboratory has previously described in isolated 1- to 4-mm calf pulmonary arteries, an endothelium-independent contraction to hypoxia that appears to involve the removal of a H2O2-elicited guanosine 3',5'-cyclic monophosphate (cGMP)-mediated relaxation. " 03/01/1992 - "With 15 min of hypoxia, PA contracted and guanosine 3',5'-cyclic monophosphate content decreased. "
4.	Melanoma (Melanoma, Malignant) 06/01/1980 - "3. Urinary excretion of guanosine 3':5'-cyclic monophosphate was significantly greater than normal in patients with lymphoid tumours (both sexes) and in male patients with myeloid tumours or malignant melanoma. " 05/28/2008 - "Guanosine promotes B16F10 melanoma cell differentiation through PKC-ERK 1/2 pathway." 02/01/1993 - "The guanosine deletion in B2m gene was detected also in the melanoma tissue from which SK-MEL-33 cells had originated. " 01/01/2014 - "Improving topical non-melanoma skin cancer treatment: In vitro efficacy of a novel guanosine-analog phosphonate." 10/31/2013 - "Our data identify GMPR as a melanoma invasion suppressor and establish a link between guanosine metabolism and Rho-GTPase-dependent melanoma cell invasion. "
5.	Chronic Hepatitis B 05/01/2006 - "Entecavir, a guanosine analog, has been recently approved in US for the therapy of chronic hepatitis B and its registration is expected soon in Europe. " 10/01/2011 - "We investigated the efficacy of entecavir, a cyclopentyl guanosine nucleoside analogue, as monoprophylaxis in patients with chronic hepatitis B who received a liver transplant. " 12/01/2000 - "Antiviral efficacy of lobucavir (BMS-180194), a cyclobutyl-guanosine nucleoside analogue, in the woodchuck (Marmota monax) model of chronic hepatitis B virus (HBV) infection." 08/01/2008 - "Entecavir is a guanosine nucleoside analogue approved for the treatment of chronic hepatitis B virus (HBV) infection. " 02/01/2008 - "Entecavir, a cyclopentyl guanosine analog, is a potent inhibitor of chronic hepatitis B virus DNA polymerase, inhibiting both the priming and elongation steps of viral DNA replication. "

Related Drugs and Biologics

1.	Cytosine
2.	DNA (Deoxyribonucleic Acid)
3.	Ribavirin (Virazole)
4.	zaprinast
5.	Adenosine
6.	Glutamic Acid (Glutamate)
7.	Guanine
8.	Cytidine
9.	Guanosine Triphosphate (GTP)
10.	Guanosine Diphosphate (GDP)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Ligation
3.	Renal Dialysis (Hemodialysis)
4.	Highly Active Antiretroviral Therapy (HAART)
5.	Immunotherapy