Guanidines

A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.

Networked: 20 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hanson, Allison S: 2 articles (09/2012 - 07/2010)
2.	Casero, Robert A: 2 articles (09/2012 - 07/2010)
3.	Woster, Patrick M: 2 articles (09/2012 - 07/2010)
4.	Steinbergs, Nora: 2 articles (09/2012 - 07/2010)
5.	Vabre, Boris: 1 article (01/2013)
6.	Khan, Muhammad Rashid: 1 article (01/2013)
7.	Zargarian, Davit: 1 article (01/2013)
8.	Shah, Naseer Ali: 1 article (01/2013)
9.	Murtaza, Ghulam: 1 article (01/2013)
10.	Khan, Hizbullah: 1 article (01/2013)

Related Diseases

1.	Edema 01/01/1977 - "All substituted guanidines (50 mg/kg) provided 1-31% protection against carrageenin-induced edema in rats. "
2.	Tetany (Spasmophilia) 10/01/1924 - "The Parathyroids, Guanidines and Tetany." 01/01/1928 - "Guanidine studies: Distribution of guanidines in acute guanidine and parathyroprivia tetanies."
3.	Atherosclerosis 06/01/2004 - "In vitro study of the potential role of guanidines in leukocyte functions related to atherogenesis and infection."
4.	Infection 06/01/2004 - "In vitro study of the potential role of guanidines in leukocyte functions related to atherogenesis and infection."
5.	Neoplasms (Cancer) 01/01/2013 - "The synthesized guanidines were tested for antitumor activities against potato tumor, and showed excellent inhibition against Agrobacterium tumefaciens (AT10)-induced tumor. " 08/01/2012 - "Effect of substitution at N″-position of N'-hydroxy-N-amino guanidines on tumor cell growth." 10/26/2011 - "Protein arginine N-methyltransferases (PRMTs) selectively replace N-H for N-CH(3) at substrate protein guanidines, a post-translational modification important for a range of biological processes, such as epigenetic regulation, signal transduction and cancer progression. " 07/22/2010 - "We recently reported a series of (bis)guanidines and (bis)biguanides that are potent inhibitors of LSD1 and induce the re-expression of aberrantly silenced tumor suppressor genes in tumor cells in vitro. " 05/01/2011 - "The WO2010078247 patent application shows the development of some novel sphingo-guanidines, including their water soluble salts, as inhibitors of SphK, and for use in treating and/or preventing diseases and disorders related to undesirable ceramidase, ceramidase-related or SphK activity, including cancer and other proliferative diseases. "

Related Drugs and Biologics

1.	Carrageenan
2.	Guanidine (Guanidine Nitrate)
3.	Biguanides
4.	Ceramidases
5.	Nitric Oxide Synthase (NO Synthase)
6.	Collagenases (Collagenase)
7.	Urea (Carbamide)
8.	Thiourea
9.	Sphingomyelin Phosphodiesterase (Sphingomyelinase)
10.	Salts

Related Therapies and Procedures

1.	Therapeutics