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Guanethidine

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An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.

Also Known As:

((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine; Guanethidine Monosulfate; Guanethidine Sulfate; Guanethidine Sulfate (1:1); Guanethidine Sulfate (1:2); Guanethidine Sulfate (2:1); Guanethidine Sulfate (2:1), 14C-Labeled; Ismelin; Isobarin; Octadine; Oktadin; Monosulfate, Guanethidine; Sulfate, Guanethidine; Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-

Networked: 568 relevant articles (31 outcomes, 45 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amidines: 11
  - Guanidines: 20
    - Guanethidine: 568

Experts

1.	Ribeiro-da-Silva, Alfredo: 2 articles (01/2015 - 06/2013)
2.	Samara, Maria: 2 articles (09/2006 - 07/2005)
3.	Paraskevas, Kosmas I: 2 articles (09/2006 - 07/2005)
4.	Wang, Xue-Long: 1 article (12/2015)
5.	Peng, Xiao-Yan: 1 article (12/2015)
6.	Huang, Ya: 1 article (12/2015)
7.	Liu, Tong: 1 article (12/2015)
8.	Chen, Li-Hua: 1 article (12/2015)
9.	Cao, Lei-Fang: 1 article (12/2015)
10.	Luo, Wei-Feng: 1 article (12/2015)

Related Diseases

1.	Pain (Aches) 03/01/1996 - "There were no significant differences between groups, but the group receiving guanethidine showed greater improvement in pain relief at all three follow up visits compared with those receiving placebo (9% v 7% at one week; 15% v 6% at four weeks and 36% v 16% at eight weeks). " 10/01/2003 - "The results of clinical studies have raised doubts on the effectiveness of regional sympathetic blocks with guanethidine (IVRSB) in patients suffering from complex regional pain syndrome (CRPS). " 06/01/1994 - "The present study investigated, for the first time whether pain suppressing, as typically occurring under the IT, would correlate in RSD to the pain relieving effect following a diagnostic guanethidine blockade. " 12/01/1986 - "Compared to placebo, guanethidine produced a decrease in pain (p less than 0.025) and an increase in pinch strength (less than 0.025) over the 2-week duration of the study. " 09/01/2011 - "Intravenous regional guanethidine block without local anaesthesia for complex regional pain syndrome."
2.	Open-Angle Glaucoma (Glaucoma, Open Angle) 09/01/1972 - "Local guanethidine drops in the treatment of chronic simple glaucoma." 08/01/1971 - "Guanethidine in chronic simple glaucoma." 05/01/1978 - "We present the results of a double-blind trial comparing the efficacy of a single dose combination of guanethidine 3% and adrenaline 0.5% with that of adrenaline 1% alone in reducing the intraocular pressure of eyes suffering from chronic open-angle glaucoma. " 04/01/1977 - "Low dosage combined adrenaline-guanethidine formulations in the management of chronic simple glaucoma." 01/01/1979 - "This study showed that an association of adrenaline and guanethidine in drop form, used in cases of open-angle glaucoma, achieved a rapid and lasting stabilisation of intraocular pressure. "
3.	Hypertension (High Blood Pressure) 03/01/1962 - "Guanethidine in the long-term management of hypertension: clinical studies." 08/20/1960 - "Clinical and pharmacological studies with guanethidine in the treatment of hypertension." 12/01/1984 - "Only combined adrenal demedullation and guanethidine pretreatment prevented ABD-induced hypertension, and autonomic blockade normalized MAP in ABD rats. " 04/01/1984 - "Guanethidine is a sympatholytic antihypertensive drug used for the treatment of severe or resistant hypertension. " 11/01/1983 - "Guanethidine-treated rats did not develop hypertension in response to isolation whereas control rats did. "
4.	Reflex Sympathetic Dystrophy (Reflex Sympathetic Dystrophy Syndrome) 12/01/1991 - "The regional guanethidine blocks seemed to be a good treatment for algodystrophy after failure of other treatments." 07/01/1983 - "Regional intravenous guanethidine vs. stellate ganglion block in reflex sympathetic dystrophies: a randomized trial." 06/15/2001 - "Use of intravenous guanethidine for the treatment of complex regional pain syndrome type I is of variable efficacy. " 11/01/1996 - "Intravenous regional guanethidine Bier block (IVRGBB) has been used predominantly in Europe for treating reflex sympathetic dystrophy (RSD). " 11/01/1996 - "Intravenous guanethidine in patients with reflex sympathetic dystrophy."
5.	Hyperalgesia 01/01/2015 - "In SNI animals, mechanical allodynia in the lateral paw was significantly improved by guanethidine at 2 and 6 weeks, and the development of cold hyperalgesia, which roughly paralleled the appearance of ectopic sympathetic fibres, was alleviated by guanethidine at 6 weeks. " 04/12/2001 - "To investigate the effect of guanethidine pretreatment on thermal hyperalgesia. " 05/01/1998 - "Sympatholytic treatment with guanethidine significantly reduced both the thermal and mechanical allodynia. " 01/01/1993 - "Guanethidine treatment was ineffective on hyperalgesia exhibited in arthritic rats but was able to reduce reliably and even suppress the abnormal reactions to cold stimulus in neuropathic animals. " 02/01/1992 - "Guanethidine (20 mg/kg, s.c.) did not abolish the allodynia in most of the rats. "

Related Drugs and Biologics

1.	Epinephrine (Adrenaline)
2.	Phentolamine (Z-Max)
3.	Lidocaine (Xylocaine)
4.	Guanethidine
5.	Methylprednisolone
6.	Methyldopa (Aldomet)
7.	Reserpine (Serpasil)
8.	Clonidine (ST 155)
9.	Prazosin (Minipress)
10.	Bethanidine (Batel)

Related Therapies and Procedures

1.	Sympathectomy (Sympathectomies)
2.	Ligation
3.	Adrenalectomy
4.	Vagotomy
5.	Ganglionectomy