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Guaifenesin

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An expectorant that also has some muscle relaxing action. It is used in many cough preparations.

Also Known As:

Breonesin; Glycerol Guaiacolate; Guaiphenezine; Guiatuss; Humibid; Hytuss; My-301; Scott-Tussin; Ether, Guaiacol Glyceryl; Glyceryl Ether, Guaiacol; Guaiacolate, Glycerol; My 301; My301; Scott Tussin; ScottTussin; Guaiacol Glyceryl Ether; Guaiphenesin; 1,2-Propanediol, 3-(2-methoxyphenoxy)-

Networked: 76 relevant articles (14 outcomes, 11 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Phenols: 309
  - Catechols: 85
    - Guaiacol: 47
      - Guaifenesin: 76
        Broncho-binotal: 2
        duopect: 1
        hexapneumine: 1
        sagittacin: 1
        beta-(2-methoxyphenoxy)lactic acid
        guaiacylglycerol-beta-coniferyl ether
        guaiacylglycerol-beta-guaiacyl ether
        guaifenesin drug combination caffeine acetaminophen
        linctifed
        veratrylglycerol-beta-guaiacyl ether
  - Phenyl Ethers: 4
    - Guaiacol: 47
      - Guaifenesin: 76
        Methocarbamol: 63
        Broncho-binotal: 2
        duopect: 1
        hexapneumine: 1
        sagittacin: 1
        beta-(2-methoxyphenoxy)lactic acid
        guaiacylglycerol-beta-coniferyl ether
        guaiacylglycerol-beta-guaiacyl ether
        guaifenesin drug combination caffeine acetaminophen
        linctifed
        veratrylglycerol-beta-guaiacyl ether
- Ethers: 174
  - Methyl Ethers: 14
    - Guaiacol: 47
      - Guaifenesin: 76
        Methocarbamol: 63
        Broncho-binotal: 2
        duopect: 1
        hexapneumine: 1
        sagittacin: 1
        beta-(2-methoxyphenoxy)lactic acid
        guaiacylglycerol-beta-coniferyl ether
        guaiacylglycerol-beta-guaiacyl ether
        guaifenesin drug combination caffeine acetaminophen
        linctifed
        veratrylglycerol-beta-guaiacyl ether
  - Phenyl Ethers: 4
    - Guaiacol: 47
      - Guaifenesin: 76
        Methocarbamol: 63
        Broncho-binotal: 2
        duopect: 1
        hexapneumine: 1
        sagittacin: 1
        beta-(2-methoxyphenoxy)lactic acid
        guaiacylglycerol-beta-coniferyl ether
        guaiacylglycerol-beta-guaiacyl ether
        guaifenesin drug combination caffeine acetaminophen
        linctifed
        veratrylglycerol-beta-guaiacyl ether

Experts

1.	Rubin, Bruce K: 2 articles (05/2014 - 07/2007)
2.	Solomon, Gail: 2 articles (01/2012 - 06/2009)
3.	Dicpinigaitis, Peter V: 2 articles (06/2009 - 12/2003)
4.	Gayle, Yvonne E: 2 articles (06/2009 - 12/2003)
5.	Turak, Fatma: 1 article (01/2016)
6.	Dinç, Erdal: 1 article (01/2016)
7.	Güzel, Remziye: 1 article (01/2016)
8.	Wu, J: 1 article (11/2015)
9.	Duckworth, H: 1 article (11/2015)
10.	Kala, A: 1 article (11/2015)

Related Diseases

1.	Cough 12/01/1982 - "The efficacy of guaifenesin in reducing cough frequency in young adults with acute respiratory disease was evaluated by both an objective cough counting system and a questionnaire. " 12/01/2003 - "Our results demonstrate that guaifenesin inhibits cough reflex sensitivity in subjects with URI, whose cough receptors are transiently hypersensitive, but not in healthy volunteers. " 12/01/2003 - "To evaluate the effect of guaifenesin on cough reflex sensitivity. " 12/01/2003 - "Guaifenesin, a commonly used agent for the treatment of cough, is termed an expectorant since it is believed to alleviate cough discomfort by increasing sputum volume and decreasing its viscosity, thereby promoting effective cough. " 12/01/2003 - "Effect of guaifenesin on cough reflex sensitivity."
2.	Respiratory Tract Infections (Respiratory Tract Infection) 01/01/2012 - "We compared the efficacy of extended-release guaifenesin with placebo for treatment of symptoms of upper respiratory tract infection using subjective efficacy assessments in a pilot study and confirmed precision of assessments in a validation study. " 01/01/2012 - "Patient-reported outcomes to assess the efficacy of extended-release guaifenesin for the treatment of acute respiratory tract infection symptoms." 05/01/2014 - "Guaifenesin has no effect on sputum volume or sputum properties in adolescents and adults with acute respiratory tract infections." 01/01/2012 - "Guaifenesin is a component of medicines used to improve symptoms associated with upper respiratory tract infections. " 11/01/2015 - "Observational studies suggest that orally administered guaifenesin (GGE) may thin lower respiratory tract secretions but none have examined its effects on mucociliary and cough clearance (MCC/CC) during a respiratory tract infection (RTI). "
3.	Common Cold 03/01/2010 - "Guaifenesin compound pseudoephedrine hydrochloride oral solution showed significant efficacy and safety in children for treatment of cough, expectoration, nasal congestion and runny nose caused by common cold or acute tracheobronchitis." 01/01/2006 - "Data for this review were obtained from several National Library of Medicine (PubMed) searches (from 1960 to 2004), which were performed between May and September 2004, of the literature published in the English language, limited to human studies, using combinations of the search terms "cough," "double-blind placebo-controlled," "antitussive," "mucolytic," "cough clearance," "common cold," "protussive," "guaifenesin," "glycerol," and "zinc." Mucolytic agents are not consistently effective in ameliorating cough in patients with bronchitis, although they may be of benefit to this population in other ways. " 01/01/2013 - "This paper reports the establishment of a method for rapid identification 15 effective components of anti common cold medicine (paracetamol, aminophenazone, pseudoephedrine hydrochloride, methylephedrine hydrochloride, caffeine, amantadine hydrochloride, phenazone, guaifenesin, chlorphenamine maleate, dextromethorphen hydrobromide, diphenhydramine hydrochloride, promethazine hydrochloride, propyphenazone, benorilate and diclofenac sodium) with MRM by LC-MS/MS. The samples were extracted by methanol and were separated from a Altantis T3 column within 15 min with a gradient of acetonitrile-ammonium acetate (containing 0.25% glacial acetic acid), a tandem quadrupole mass spectrometer equipped with electrospray ionization source (ESI) was used in positive ion mode, and multiple reaction monitoring (MRM) was performed for qualitative analysis of these compounds. "
4.	Bronchitis 01/01/1974 - "Changes in the fibre system and viscosity of the sputum of bronchitis during treatment with bromhexine and guaiphenesin (guaiacol glyceryl ether)." 01/01/2006 - "Data for this review were obtained from several National Library of Medicine (PubMed) searches (from 1960 to 2004), which were performed between May and September 2004, of the literature published in the English language, limited to human studies, using combinations of the search terms "cough," "double-blind placebo-controlled," "antitussive," "mucolytic," "cough clearance," "common cold," "protussive," "guaifenesin," "glycerol," and "zinc." Mucolytic agents are not consistently effective in ameliorating cough in patients with bronchitis, although they may be of benefit to this population in other ways. "
5.	Seizures (Seizure) 06/01/2013 - "The ED50s of Guaifenesin for protection against PTZ-induced clonic and tonic-clonic seizures and death were 744.88 (360-1540), 256 (178-363), and 328 (262-411) mg/kg, respectively. " 06/01/2013 - "In addition, Guaifenesin at the dose of 300 mg/kg increased the latency to tonic-clonic seizure. " 06/01/2013 - "Guaifenesin at all the studied doses significantly increased the latency to myoclonic and clonic convulsions in a dose-dependent manner. " 06/01/2013 - "Anticonvulsant effect of Guaifenesin was assessed via Pentylenetetrazol (PTZ)-induced convulsion. " 06/01/2013 - "Anticonvulsant Effect of Guaifenesin against Pentylenetetrazol-Induced Seizure in Mice."

Related Drugs and Biologics

1.	Expectorants (Mucolytics)
2.	Dextromethorphan (Levomethorphan)
3.	Pseudoephedrine
4.	Codeine (Codeine Phosphate)
5.	Diphenhydramine (Benadryl)
6.	Glycerol (Glycerine)
7.	Zinc
8.	Anti-Bacterial Agents (Antibiotics)
9.	Narcotics (Narcotic Analgesics)
10.	Antitussive Agents (Antitussives)

Related Therapies and Procedures

1.	Anesthesia
2.	Transplants (Transplant)