Guaiacol

An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)

Also Known As:

2-Hydroxy-Anisole; 2-Hydroxyanisole; 2-Methoxy-Phenol; 2-Methoxyphenol; Guaicol; Methyl Catechol; Catechol, Methyl; Phenol, 2-methoxy-

Networked: 73 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Catechols: 121
        Guaiacol: 73
        Guaifenesin: 117
        zingerone: 106
        gigantol: 30
        dihydroguaiaretic acid: 20
        6-paradol: 13
        cinnamophilin: 8
        yakuchinone-A: 7
        4-ethylguaiacol: 4
        CA 432: 4
        guaiacolsulfonic acid: 4
        6-dehydrogingerdione: 3
        6-gingesulfonic acid: 3
        hylin: 3
        metoxibutropate: 3
        (10)-shogaol: 2
        (8)-shogaol: 2
        1,4-O-diferuloylsecoisolariciresinol: 2
        2-(4-hydroxy-3-methoxyphenyl)benzothiazole: 2
        4-vinylguaiacol: 2
        dehydroparadol: 2
        12-dehydrogingerdione: 1
        2,3-dihydroxy-4-methoxyacetophenone: 1
        2-methoxy-4-vinylphenol: 1
        3-(3-hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,2,5-selenadiazole: 1
        4-(3-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one: 1
        gingerdione: 1
        N-(4-hydroxy-3,5-dimethoxyphenethyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide: 1
        terpene drug combination sulfurgaicol codeine bromoform: 1
        (10)-dehydrogingerdione
        (10)-gingerdiol
        (E)-2-((2-chlorobenzylimino)methyl)methoxyphenol
        (Z)-2-(3-methoxybenzylidene)-1-azabicyclo(2.2.2)octan-3-one
        1,2,2-trithioeethyl ethylguaiacol
        1,2-dihydroxy-1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3'',4'',5''-trimethoxyphenyl)ethane
        1,4-dimethoxycatechol
        1-(4-(3-fluoropropoxy)-3-methoxyphenyl)-5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one
        1-(4-hydroxy-3-methoxyphenyl)-2-(4-(3-hydroxypropyl)-2-methoxyphenoxy)propane-1,3-diol
        1-(4-hydroxy-3-methoxyphenyl)-2-propanone
        1-hydroxy-2,5-diguaicyl-3,7-dioxabicyclo(3.3.0)octane
        10-hydroxyoleuropein
        2'-methoxy-5'-(1-(4'-methoxybenzyl)-4,5-dimethyl-3-(3'',4'',5''-trimethoxyphenyl)-1H-pyrrol-2-yl)phenol
        2,2'-dihydroxy-5,5'-dimethoxybiphenyl-3,3'-dicarbaldehyde
        2-(3-hydroxy-4-methoxybenzylidene)-1-azabicyclo(2.2.2)octan-3-one
        2-(3-hydroxy-4-methoxyphenyl)-3-((3,4,5-trimethoxyphenyl)carbonyl)thiophene
        2-(3-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)thiophene
        2-(3-methoxy-4-hydroxyphenyl)-3-hydroxymethyl-5-carboxyethylene-7-methoxy-2,3-dihydrobenzofuran
        2-(3-methoxy-4-hydroxyphenyl)ethanol-O-arabinopyranosyl-(1-2)-rhamnopyranosyl-(1-3)-glucopyranoside
        2-(3-methoxyl-4-hydroxyphenyl)ethanol-O-rhamnopyranosyl-(1-3) (glucopyranosyl-(1-6))-glucopyranoside
        2-guaiacolethanol acetylsalicylate
        2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol
        3,3'-dimethoxy-4,4'-dihydroxystilbene
        3,4,5-trichloroguaiacol
        3,4,6-trichloroguaiacol
        3-hydroxy-4-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one
        3-hydroxy-4-methoxybenzaldehyde thiosemicarbazone
        3-vanillyl propanol
        4,5,6-trichloroguaiacol
        4,8-bis(4-hydroxy-3-methoxyphenyl)-3,7-dioxabicyclo(3.3.0)octane-2,6-dione
        4-(1-ethoxy-1-(4-hydroxy-3-methoxy)benzyl)methyl-2-(4-hydroxy-3-methoxy)benzyl-3-hydroxymethyltetrahydrofuran
        4-(3-hydroxymethyl-5-(3-hydroxypropyl)-2,3-dihydrobenzofuran-2-yl)-2-methoxyphenol
        4-(5-(4-hydroxy-3-methoxyphenyl)-3-oxopenta-1,4-dienyl)-2-methoxyphenol
        4-bromo-2-methoxyphenol
        4-chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide
        4-chloroguaiacol
        4-fluoroguaiacol
        4-hydroxy-N-(3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl)-3-methoxybenzamide
        4-methyl-2,6-dicarbomethoxyphenol
        4-propylguaiacol
        5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-3- heptanone
        7,7'-oxodihydroguaiaretic acid
        7,8-dihydro-9'-dehydroxyimperanene
        8'-hydroxylariciresinol-4'-O-glucopyranoside
        9'-dehydroxyimperanene
        apocynol
        aza-(6)-gingerol
        bisvanillyl-hydralazone
        deoxysappanone B 7,4' dimethyl ether
        erythro-guaiacylglycerol-beta-ferulic acid ether
        FR dental filling
        graminone B
        guaiacol salicylate
        guaiacol-salsalate
        isoquebecol
        mimosifoliol
        N,N'-bis(2-hydroxy-3-methoxybenzylidene)-1,2-diaminobenzene
        N,N'-bis(2-hydroxy-3-methoxybenzylidene)-1,3-diaminobenzene
        N-(2-bromo-5-hydroxy-4-methoxybenzylidene)-2-methylpropan-2-amine oxide
        PCG (combination)
        pinopalustrin
        pyrrolidinemethyltetracycline guaiacol sulfonate
        rourinoside
        scaphopetalone
        Shin Ruru A
        solorinine
        tetrachloroguaiacol
        tetraguaiacol
        thioguaiacol
        XH-14
        Phenyl Ethers: 8
        Guaiacol: 73
        Guaifenesin: 117
        zingerone: 106
        gigantol: 30
        dihydroguaiaretic acid: 20
        6-paradol: 13
        cinnamophilin: 8
        yakuchinone-A: 7
        4-ethylguaiacol: 4
        CA 432: 4
        guaiacolsulfonic acid: 4
        6-dehydrogingerdione: 3
        6-gingesulfonic acid: 3
        hylin: 3
        metoxibutropate: 3
        (10)-shogaol: 2
        (8)-shogaol: 2
        1,4-O-diferuloylsecoisolariciresinol: 2
        2-(4-hydroxy-3-methoxyphenyl)benzothiazole: 2
        4-vinylguaiacol: 2
        dehydroparadol: 2
        12-dehydrogingerdione: 1
        2,3-dihydroxy-4-methoxyacetophenone: 1
        2-methoxy-4-vinylphenol: 1
        3-(3-hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,2,5-selenadiazole: 1
        4-(3-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one: 1
        gingerdione: 1
        N-(4-hydroxy-3,5-dimethoxyphenethyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide: 1
        terpene drug combination sulfurgaicol codeine bromoform: 1
        (10)-dehydrogingerdione
        (10)-gingerdiol
        (E)-2-((2-chlorobenzylimino)methyl)methoxyphenol
        (Z)-2-(3-methoxybenzylidene)-1-azabicyclo(2.2.2)octan-3-one
        1,2,2-trithioeethyl ethylguaiacol
        1,2-dihydroxy-1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3'',4'',5''-trimethoxyphenyl)ethane
        1,4-dimethoxycatechol
        1-(4-(3-fluoropropoxy)-3-methoxyphenyl)-5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one
        1-(4-hydroxy-3-methoxyphenyl)-2-(4-(3-hydroxypropyl)-2-methoxyphenoxy)propane-1,3-diol
        1-(4-hydroxy-3-methoxyphenyl)-2-propanone
        1-hydroxy-2,5-diguaicyl-3,7-dioxabicyclo(3.3.0)octane
        10-hydroxyoleuropein
        2'-methoxy-5'-(1-(4'-methoxybenzyl)-4,5-dimethyl-3-(3'',4'',5''-trimethoxyphenyl)-1H-pyrrol-2-yl)phenol
        2,2'-dihydroxy-5,5'-dimethoxybiphenyl-3,3'-dicarbaldehyde
        2-(3-hydroxy-4-methoxybenzylidene)-1-azabicyclo(2.2.2)octan-3-one
        2-(3-hydroxy-4-methoxyphenyl)-3-((3,4,5-trimethoxyphenyl)carbonyl)thiophene
        2-(3-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)thiophene
        2-(3-methoxy-4-hydroxyphenyl)-3-hydroxymethyl-5-carboxyethylene-7-methoxy-2,3-dihydrobenzofuran
        2-(3-methoxy-4-hydroxyphenyl)ethanol-O-arabinopyranosyl-(1-2)-rhamnopyranosyl-(1-3)-glucopyranoside
        2-(3-methoxyl-4-hydroxyphenyl)ethanol-O-rhamnopyranosyl-(1-3) (glucopyranosyl-(1-6))-glucopyranoside
        2-guaiacolethanol acetylsalicylate
        2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol
        3,3'-dimethoxy-4,4'-dihydroxystilbene
        3,4,5-trichloroguaiacol
        3,4,6-trichloroguaiacol
        3-hydroxy-4-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)azetidin-2-one
        3-hydroxy-4-methoxybenzaldehyde thiosemicarbazone
        3-vanillyl propanol
        4,5,6-trichloroguaiacol
        4,8-bis(4-hydroxy-3-methoxyphenyl)-3,7-dioxabicyclo(3.3.0)octane-2,6-dione
        4-(1-ethoxy-1-(4-hydroxy-3-methoxy)benzyl)methyl-2-(4-hydroxy-3-methoxy)benzyl-3-hydroxymethyltetrahydrofuran
        4-(3-hydroxymethyl-5-(3-hydroxypropyl)-2,3-dihydrobenzofuran-2-yl)-2-methoxyphenol
        4-(5-(4-hydroxy-3-methoxyphenyl)-3-oxopenta-1,4-dienyl)-2-methoxyphenol
        4-bromo-2-methoxyphenol
        4-chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide
        4-chloroguaiacol
        4-fluoroguaiacol
        4-hydroxy-N-(3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl)-3-methoxybenzamide
        4-methyl-2,6-dicarbomethoxyphenol
        4-propylguaiacol
        5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-3- heptanone
        7,7'-oxodihydroguaiaretic acid
        7,8-dihydro-9'-dehydroxyimperanene
        8'-hydroxylariciresinol-4'-O-glucopyranoside
        9'-dehydroxyimperanene
        apocynol
        aza-(6)-gingerol
        bisvanillyl-hydralazone
        deoxysappanone B 7,4' dimethyl ether
        erythro-guaiacylglycerol-beta-ferulic acid ether
        FR dental filling
        graminone B
        guaiacol salicylate
        guaiacol-salsalate
        isoquebecol
        mimosifoliol
        N,N'-bis(2-hydroxy-3-methoxybenzylidene)-1,2-diaminobenzene
        N,N'-bis(2-hydroxy-3-methoxybenzylidene)-1,3-diaminobenzene
        N-(2-bromo-5-hydroxy-4-methoxybenzylidene)-2-methylpropan-2-amine oxide
        PCG (combination)
        pinopalustrin
        pyrrolidinemethyltetracycline guaiacol sulfonate
        rourinoside
        scaphopetalone
        Shin Ruru A
        solorinine
        tetrachloroguaiacol
        tetraguaiacol
        thioguaiacol
        XH-14
- Ethers: 242
  - Methyl Ethers: 19
    - Guaiacol: 73
  - Phenyl Ethers: 8
    - Guaiacol: 73

Experts

1.	Hassanali, Ahmed: 3 articles (01/2021 - 05/2007)
2.	Kabaka, Joy M: 2 articles (01/2021 - 11/2020)
3.	Mireji, Paul O: 2 articles (01/2021 - 11/2020)
4.	Murilla, Grace A: 2 articles (01/2021 - 11/2020)
5.	Okoth, Sylvance O: 2 articles (01/2021 - 11/2020)
6.	Wachira, Benson M: 2 articles (01/2021 - 11/2020)
7.	Boltia, Shereen A: 2 articles (07/2019 - 09/2018)
8.	Tsutsui, Takeki: 2 articles (01/2008 - 01/2005)
9.	Gür, Bahri: 1 article (10/2022)
10.	Gür, Fatma: 1 article (10/2022)

Related Diseases

1.	Hypothermia 01/15/2022 - "Although the pharmacokinetics indicated facile clearance of parent O-methyl catechol nucleosides 21 and 31, prolonged mA3AR activation in vivo was observed in a hypothermia model, suggested potential formation of active metabolites through demethylation. "
2.	Wounds and Injuries (Trauma) 08/01/1976 - "[Clinico-pathological study on the effects of guaiacol and zinc oxide guaiacol to the wounds of pulp and periapical tissues after vital pulpectomy (author's transl)]." 07/01/2002 - "Since peroxidase is known to catalyse the cross-linking of cell wall polymers, we stained native and wound periderm for the presence of peroxidase utilizing guaiacol as a substrate. "
3.	Atherosclerotic Plaque (Atheroma) 01/01/2020 - "This study reveals that there is great potential for guaiacol derivatives as therapeutics for CVD by modulating lipid profiles, reducing atherosclerotic plaque burden, and subsequently optimizing cardiovascular functions."
4.	Hyperpigmentation 10/01/2022 - "The present study aims to investigate the substrate (4-methyl catechol and catechol) specificity and inhibition mechanisms (l-ascorbic acid, citric acid, and l-cysteine) of the tyrosinase enzyme (TYR), which is held responsible for browning in foods and hyperpigmentation in the human skin, through kinetic and molecular docking studies. "
5.	Trypanosomiasis 05/01/2007 - "Our study shows that the presence of a methyl substituent at the 4-position of guaiacol enhances the repellency of the molecule to savannah tsetse and suggests that 4-methylguaiacol may represent a promising additional tool in the arsenal of techniques in trypanosomiasis control."

Related Drugs and Biologics

1.	Nucleosides
2.	Peroxidase (Myeloperoxidase)
3.	Zinc Oxide
4.	Enzymes
5.	catechol (pyrocatechol)
6.	Citric Acid (Citrate)
7.	Monophenol Monooxygenase (Tyrosinase)
8.	Lipids
9.	Cysteine (L-Cysteine)
10.	Cyclodextrins

Related Therapies and Procedures

1.	Therapeutics
2.	Pulpectomy
3.	Pallidotomy
4.	Deep Brain Stimulation
5.	Occupational Therapy (Therapy, Occupational)