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GTP Cyclohydrolase (GTP Cyclohydrolase I)

(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
Also Known As:
GTP Cyclohydrolase I; GTP Cyclohydrolase II; 7,8-Dihydroneopterintriphosphate Synthetase; 7,8 Dihydroneopterintriphosphate Synthetase; 8-Formylhydrolase, GTP; Cyclohydrolase I, GTP; Cyclohydrolase II, GTP; Cyclohydrolase, GTP; Dihydrolase, GTP; GTP 8 Formylhydrolase; GTP Ring Opening Enzyme; Ring-Opening Enzyme, GTP; Synthetase, 7,8-Dihydroneopterintriphosphate; GTP 8-Formylhydrolase; GTP Dihydrolase; GTP Ring-Opening Enzyme; GTP 7,8-8,9-dihydrolase
Networked: 302 relevant articles (9 outcomes, 27 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Channon, Keith M: 16 articles (01/2017 - 03/2004)
2. Lötsch, Jörn: 10 articles (02/2013 - 11/2006)
3. Tegeder, Irmgard: 9 articles (06/2015 - 11/2006)
4. Ichinose, Hiroshi: 6 articles (01/2019 - 05/2004)
5. Alp, Nicholas J: 6 articles (05/2010 - 03/2004)
6. Blau, Nenad: 5 articles (01/2021 - 05/2006)
7. Shi, Yang: 5 articles (09/2017 - 01/2012)
8. Geisslinger, Gerd: 5 articles (02/2013 - 11/2006)
9. Segawa, Masaya: 5 articles (12/2011 - 11/2003)
10. Chen, Alex F: 5 articles (12/2010 - 09/2003)

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