Growth Inhibitors

Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth (= PLANT GROWTH REGULATORS).

Also Known As:

Networked: 243 relevant articles (2 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pettit, George R: 11 articles (03/2015 - 02/2004)
2.	Pettit, Robin K: 7 articles (03/2008 - 02/2004)
3.	Chapuis, Jean-Charles: 6 articles (03/2015 - 02/2004)
4.	Doubek, Dennis L: 6 articles (03/2008 - 02/2004)
5.	Herald, Delbert L: 4 articles (01/2005 - 02/2004)
6.	Kawachi, Takashi: 3 articles (03/2015 - 07/2014)
7.	Kobayashi, Motomasa: 3 articles (03/2015 - 07/2014)
8.	Arai, Masayoshi: 3 articles (03/2015 - 07/2014)
9.	Ivanek, Renata: 3 articles (11/2011 - 05/2009)
10.	Pradhan, Abani K: 3 articles (11/2011 - 05/2009)

Related Diseases

1.	Adenocarcinoma 12/01/2009 - "Identification of the targets of LCS-1 and other growth inhibitors found in this screen may help to develop new agents for the treatment of lung adenocarcinomas, including those driven by mutant EGFR and KRAS." 02/01/1996 - "Retinoids including retinoic acid (RA) have been demonstrated to be effective growth inhibitors of a number of human cancer cell lines including ovarian adenocarcinoma cells. "
2.	Thyroid Neoplasms (Thyroid Cancer) 03/15/2006 - "Compounds that inhibit kinase activity are effective growth inhibitors for poorly differentiated thyroid cancer cell lines with either RET or RAF mutations, and hold promise for treatment of most forms of papillary thyroid carcinoma."
3.	Neoplasms (Cancer) 10/01/2014 - "In our study, we tested two different toxins derived from class II addictive modules, pasAB from plasmid pTF-FC2 (Thiobacillus ferrooxidans) and vapBC 2829Rv (Mycobacterium tuberculosis), in terms of their usefulness as growth inhibitors of human cancer cell lines, namely KYSE 30, MCF-7 and HCT 116. " 09/01/2015 - "Follow-up experiments are focused on the tumor suppressor HHEX, one of the strongest growth inhibitors. " 06/01/2015 - "However, mutations in genes that encode growth inhibitors can trigger the onset of tumorigenesis and cancer. " 03/27/2015 - "The recent advances in the development of antibody and other drug conjugates for targeted cancer treatment have further increased the need for powerful cancer cell growth inhibitors. " 12/01/2013 - "Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53."
4.	Breast Neoplasms (Breast Cancer) 04/01/2000 - "In this review, we present an overview of current information about major autocrine and paracrine growth inhibitors of breast epithelial cells, and we discuss their potential functions in the control of breast cancer development." 04/01/2000 - "Autocrine and paracrine growth inhibitors of breast cancer cells." 01/01/1997 - "Very few growth inhibitors have been identified which can inhibit the proliferation of a broad spectrum of human breast cancer cell lines. " 06/09/1995 - "Vitamin-D3 derivatives are now well-recognized growth inhibitors of numerous tumoral cells and in particular breast-cancer cells. " 01/01/2012 - "The Cancer BioChip System (CBCS) allows for the simultaneous, quantitative, and real time evaluation of multitudes of anchorage-independent breast cancer cell growth inhibitors. "
5.	Neoplasm Metastasis (Metastasis) 05/01/1997 - "Most studies have focused on the phenomenon, that advanced tumors or metastases have lost the sensitivity to growth inhibitors. " 02/01/2008 - "Hallmarks of cancer development include self-sufficiency in growth signals, insensitivity to growth-inhibitors, evasion of apoptosis, limitless replicative potential, tissue invasion and metastasis, and sustained angiogenesis. " 01/01/1996 - "Most of these studies have focused on the phenomenon, that advanced and more aggressive tumors or metastases lost the sensitivity to growth inhibitors, such as transforming growth factor beta. " 01/01/2015 - "Curcumin has been shown to act in a multi-faceted manner by targeting the classical hallmarks of cancer like sustained proliferation, evasion of apoptosis, sustained angiogenesis, insensitivity to growth inhibitors, tissue invasion and metastasis etc. However, one of the emerging hallmarks of cancer is the avoidance of immune system by tumors. " 01/01/2000 - "Organ specific tumor metastasis is thought in part to require the ability of metastatic cells to respond to target-organ-associated growth factors or to avoid the effects of target organ associated growth inhibitors. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	papillary Thyroid cancer
3.	Transforming Growth Factor beta (TGF-beta)
4.	Hormones
5.	Methotrexate (Mexate)
6.	Progesterone
7.	Iron
8.	Chelating Agents
9.	Mitogens
10.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Transplants (Transplant)
4.	Stents
5.	Vasectomy (Vas Occlusion)