Growth Inhibitors

Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth (= PLANT GROWTH REGULATORS).

Also Known As:

Growth Inhibitor, Cell; Growth Inhibitors, Cell; Inhibitor, Cell Growth; Inhibitor, Growth; Inhibitors, Cell Growth; Inhibitors, Growth; Cell Growth Inhibitor; Cell Growth Inhibitors; Growth Inhibitor

Networked: 787 relevant articles (16 outcomes, 63 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Physiological Effects of Drugs: 1
    - Growth Substances: 16
      - Growth Inhibitors: 787
        Angiogenesis Inhibitors: 3809

Experts

1.	Pettit, George R: 22 articles (01/2018 - 09/2002)
2.	Zhang, Ning: 11 articles (11/2018 - 07/2009)
3.	Chapuis, Jean-Charles: 11 articles (01/2018 - 02/2004)
4.	Pettit, Robin K: 11 articles (07/2010 - 04/2003)
5.	Arai, Masayoshi: 10 articles (01/2020 - 04/2014)
6.	Herald, Delbert L: 10 articles (05/2015 - 04/2003)
7.	Kobayashi, Motomasa: 9 articles (03/2019 - 04/2014)
8.	Kotoku, Naoyuki: 8 articles (03/2019 - 04/2014)
9.	Yang, Yong: 8 articles (11/2018 - 01/2013)
10.	Jiang, Wen G: 8 articles (01/2017 - 01/2006)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2016 - "We also show that decreased response of tumor cells to growth inhibitors can reduce the size of the Allee region and increase stem cell densities, which may help to explain why this phenomenon is a hallmark of cancer." 03/01/2018 - "These systematic studies provide insights in the development of novel AHAMACs compounds as potential cell growth inhibitors for cancer treatment." 09/30/2014 - "In our study, we tested two different toxins derived from class II addictive modules, pasAB from plasmid pTF-FC2 (Thiobacillus ferrooxidans) and vapBC 2829Rv (Mycobacterium tuberculosis), in terms of their usefulness as growth inhibitors of human cancer cell lines, namely KYSE 30, MCF-7 and HCT 116. " 09/01/2010 - "The findings of this in vivo study suggest that SVB may have potential as a tumor growth inhibitor. " 03/23/2007 - "For the first time this study demonstrates the potential usage of anti-TfR scFv-intrabody as a growth inhibitor of TfR overexpressing tumors."
2.	Infections 10/31/2021 - "Here, we evaluated eight novel membrane-affecting anti-APEC small molecule growth inhibitors (GIs), identified in our previous study, against APEC infection in chickens. " 01/01/2022 - "These small molecules and the workflow, featuring a high-throughput phenotypic screen for growth inhibitors of intracellular Rickettsia spp. and machine learning models for the prediction of growth inhibition of an obligate intracellular Gram-negative bacterium, should prove useful in the search for new therapeutic strategies to treat infections from Rickettsia spp. and other obligate intracellular bacteria." 10/31/2021 - "Novel Small Molecule Growth Inhibitor Affecting Bacterial Outer Membrane Reduces Extraintestinal Pathogenic Escherichia coli (ExPEC) Infection in Avian Model." 12/01/2018 - "They act as growth inhibitors for many microorganisms: they are released upon microbial attack, helping to fight infection in plant tissues. " 08/01/1997 - "Retroviral infection of keratinocytes with E7-expressing constructs resulted in growth inhibitor resistance, whereas infection with E6 constructs did not. "
3.	Melanoma (Melanoma, Malignant) 11/01/2023 - "based on the developed tool we were able to produce QSAR models and identify a wide variety of molecules with potential melanoma cell growth inhibitors, many of which with anti-tumoral activity already described. " 08/07/2023 - "Artichoke as a melanoma growth inhibitor." 12/17/2012 - "The role of IFN-γ in melanoma is not fully understood: it is a well-known growth inhibitor of melanoma cells in vitro. " 12/07/2011 - "Morphological changes in early melanoma development: influence of nutrients, growth inhibitors and cell-adhesion mechanisms." 12/31/2018 - "Moreover, these compounds are potent growth inhibitors of colon, central nervous system, melanoma, ovarian, and renal cancer cell lines with 50% growth inhibition values as low as 1.04 μM."
4.	Lung Neoplasms (Lung Cancer) 01/01/2021 - "This study aimed to observe the efficacy of continuous i.v. infusion of Recombinant Human Vascular Endothelial Growth Inhibitor (rhVEGI) in combination with chemotherapy in patients with advanced lung cancer (ALC). " 01/01/2021 - "Efficacy of continuous i.v. infusion of recombinant human vascular endothelial growth inhibitor in combination with chemotherapy in patients with advanced lung cancer." 01/01/2018 - "As an efficient tumor growth inhibitor with relatively small molecular weight, BTO is a viable addition to the existing list of lung cancer treatment." 01/01/2014 - "In the present study, we demonstrated that curcumin acted as a growth inhibitor for lung cancer cells. " 11/02/2010 - "Secondary metabolite mapping of lung cancer growth inhibitors in crude extracts may be an important first step to qualify Chinese herbal prescriptions required for meaningful clinical trials of such integrated therapies."
5.	Neoplasm Metastasis (Metastasis) 05/01/1997 - "Most studies have focused on the phenomenon, that advanced tumors or metastases have lost the sensitivity to growth inhibitors. " 11/24/2023 - "It is involved in classic ensigns of cancers such as self-dependent growth, resistance to growth inhibitors, restricting apoptosis, cancer metastasis, and bone-related disorders. " 08/24/2023 - "It includes the capacity to regulate proliferative signalling, circumvent growth inhibitors, escape cell death, enable replicative immortality, promote angiogenesis, stimulate invasion and metastasis, prevent immunological destruction, and genomic instability. " 01/01/2021 - "Its potentialities have been recorded against the standard hallmarks of cancer such as continuous proliferation, escaping apoptosis, continuous angiogenesis, insensitivity to growth inhibitors, tissue invasion, and metastasis. " 02/01/2008 - "Hallmarks of cancer development include self-sufficiency in growth signals, insensitivity to growth-inhibitors, evasion of apoptosis, limitless replicative potential, tissue invasion and metastasis, and sustained angiogenesis. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Phosphotransferases (Kinase)
3.	Proteins (Proteins, Gene)
4.	Thalidomide (Thalomid)
5.	Sulfadimethoxine
6.	Octreotide (Sandostatin)
7.	Tyrosine (L-Tyrosine)
8.	Metals
9.	ErbB Receptors (EGF Receptor)
10.	Charcoal (Charbon)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Radioimmunotherapy
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Stents