Chronic Granulomatous Disease

A recessive X-linked defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation.
Also Known As:
Granulomatous Disease, Chronic; Chronic Granulomatous Diseases; Disease, Chronic Granulomatous; Diseases, Chronic Granulomatous; Granulomatous Diseases, Chronic
Networked: 1408 relevant articles (32 outcomes, 89 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Infection
2. Aspergillosis
3. X-Linked Combined Immunodeficiency Diseases (X Linked Severe Combined Immunodeficiency)
4. Wiskott-Aldrich Syndrome (Syndrome, Wiskott-Aldrich)
5. Acquired Immunodeficiency Syndrome (AIDS)


1. Malech, Harry L: 35 articles (04/2015 - 03/2002)
2. Holland, Steven M: 34 articles (11/2015 - 03/2002)
3. Roos, Dirk: 26 articles (12/2015 - 03/2002)
4. Dinauer, Mary C: 18 articles (01/2014 - 03/2002)
5. Gallin, John I: 17 articles (11/2015 - 03/2002)
6. Segal, Brahm H: 16 articles (05/2014 - 03/2002)
7. de Boer, Martin: 15 articles (12/2015 - 03/2002)
8. Roesler, Joachim: 13 articles (12/2013 - 12/2002)
9. Zarember, Kol A: 10 articles (11/2015 - 05/2007)
10. Marciano, Beatriz E: 10 articles (11/2015 - 09/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Granulomatous Disease:
1. Interferon-gamma (Interferon, gamma)IBA
2. Adrenal Cortex Hormones (Corticosteroids)IBA
3. Superoxides (Superoxide)IBA
4. Itraconazole (Sporanox)FDA LinkGeneric
5. Trimethoprim (Proloprim)FDA LinkGeneric
6. SulfamethoxazoleFDA LinkGeneric
7. NADPH Oxidase (NAD(P)H oxidase)IBA
8. Adenosine DeaminaseIBA
9. Nitroblue TetrazoliumIBA
10. Peroxidase (Myeloperoxidase)IBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
09/01/2012 - "Disseminated disease mainly occurs in immunocompromised patients with underlying illnesses such as chronic granulomatous disease, human immunodeficiency virus (HIV) infection, in patients undergoing cytotoxic chemotherapy, organ transplantation or prolonged glucocorticoid treatment. "
07/01/1991 - "Disseminated infection with Pseudallescheria boydii in a patient with chronic granulomatous disease: response to gamma-interferon plus antifungal chemotherapy."
11/01/2000 - "Cytokines are increasingly used for the therapy of infections in patient populations with special defects in immunity (chemotherapy, bone marrow transplantation, chronic granulomatous disease). "
06/01/2009 - "Granulocyte transfusion is a useful adjunct to antimicrobials and growth factors in post chemotherapy neutropenic sepsis and is highly effective in children with chronic granulomatous disease and life threatening infections."
07/01/1986 - "Because of their central role in host defense (in inflammatory responses, in antigen presentation, and in immunoregulatory networks), monocyte/macrophage dysfunction may result in one or more pathophysiologic consequences: defects in monocyte maturation, deficiencies in the clearance of physiologic substrates in lysosomal diseases (e.g., Gaucher's disease, mucopolysaccharidoses, osteopetrosis, metachromatic leukodystrophy), decreased synthesis and secretion of mediators (complement component deficiencies), defects in microbicidal activity (chronic granulomatous disease) and defects which are acquired following infection and during chemotherapy (e.g., acquired immune deficiency syndrome)."
2. Immunotherapy
3. Bone Marrow Transplantation (Transplantation, Bone Marrow)
4. Transplants (Transplant)
5. Hematopoietic Stem Cell Transplantation