Granuloma Inguinale (Donovanosis)

Anogenital ulcers caused by Calymmatobacterium granulomatis as distinguished from lymphogranuloma inguinale (see LYMPHOGRANULOMA VENEREUM) caused by CHLAMYDIA TRACHOMATIS. Diagnosis is made by demonstration of typical intracellular Donovan bodies in crushed-tissue smears.

Also Known As:

Networked: 134 relevant articles (9 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Chancroid
2.	Syphilis
3.	Ulcer
4.	Infection
5.	Bacterial Vaginosis

Experts

1.	Venyo, Anthony Kodzo-Grey: 1 article (01/2015)
2.	Kanwar, A J: 1 article (11/2012)
3.	Narang, T: 1 article (11/2012)
4.	Monti, E: 1 article (08/2012)
5.	Lattuada, D: 1 article (08/2012)
6.	Bolis, G: 1 article (08/2012)
7.	Pignatari, C: 1 article (08/2012)
8.	Mangano, S: 1 article (08/2012)
9.	Liverani, C A: 1 article (08/2012)
10.	Puglia, D: 1 article (08/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Granuloma Inguinale:

1.	Anti-Bacterial Agents (Antibiotics)IBA 03/01/1952 - "A five-year study of antibiotics in the treatment of granuloma inguinale." 05/01/2004 - "Many antibiotics are used in the treatment of donovanosis. " 02/01/1995 - "Donovanosis is usually treated by readily available antibiotics but treatment failure may occur in advanced HIV disease. " 12/01/1991 - "The antibiotics reported as showing good activity in donovanosis are those with good activity against gram negative bacilli and whose lipid solubility ensures good intracellular penetration. " 11/01/1991 - "Although the availability of antibiotics has reduced the general incidence of donovanosis, the disease remains prevalent in India, Papua New Guinea, parts of southern Africa, and the West Indies. "
2.	Streptomycin (Streptomycin Sulfate)FDA Link 12/01/1971 - "Continued efficacy of streptomycin in the treatment of granuloma inguinale." 01/01/1950 - "[Efficacy of streptomycin in granuloma venereum; two observations]." 10/01/1950 - "Granuloma inguinale of the cervix uteri and vulva treated with streptomycin." 09/01/1950 - "Granuloma inguinale treated by vulvectomy and streptomycin; report of four cases." 08/01/1950 - "Streptomycin in the treatment of granuloma inguinale of the cervix uteri and vulva."
3.	Tetracycline (Achromycin)FDA LinkGeneric 05/01/1981 - "In the therapy of granuloma venereum Cotrimoxazol proved to be even more effective than tetracycline. " 07/01/1977 - "Tetracycline-resistant granuloma inguinale." 06/01/1955 - "Tetracycline (tetracyn) in the treatment of donovanosis." 11/01/1954 - "The effect of tetracycline hydrochloride in lymphogranuloma venereum and donovanosis." 01/01/2009 - "Trimethoprim-sulfamethoxazole has replaced tetracycline derivatives as preferred treatment for donovanosis in many regions. "
4.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)FDA LinkGeneric 12/01/1980 - "Further evidence of the efficacy of co-trimoxazole in granuloma venereum." 10/01/1978 - "Efficacy of co-trimoxazole in Donovanosis. " 12/01/1980 - "Co-trimoxazole is considered to be the treatment of choice for granuloma venereum because of its high efficacy, few side effects, easy administration, and absence of any risk of masking concomitant syphilis." 01/01/2009 - "Trimethoprim-sulfamethoxazole has replaced tetracycline derivatives as preferred treatment for donovanosis in many regions. " 12/01/1980 - "One hundred and sixteen patients with granuloma venereum were treated with cotrimoxazole two tablets twice daily. "
5.	Azithromycin (Zithromax)FDA LinkGeneric 02/01/1996 - "A further 17 patients with donovanosis who were unable to meet the entry criteria were also treated successfully with azithromycin during the study period. " 08/01/2012 - "A diagnosis of vulvar and perianal donovanosis was reached; the patient decided to terminate the pregnancy and was treated with azithromycin, which led to clinical resolution." 01/01/2009 - "A diagnosis of pelvic donovanosis was reached; the patient was treated with azithromycin resulting in clinical and radiographic resolution." 05/01/2004 - "[Short treatment of donovanosis with azithromycin]." 01/01/1998 - "Donovanosis: treatment with azithromycin."
6.	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 04/01/1994 - "The pharmacokinetics and safety profile of ceftriaxone make it a useful and cost-effective agent in the ambulatory management of donovanosis, especially in remote communities. " 04/01/1994 - "To determine the effectiveness of intramuscular (IM) ceftriaxone sodium in the treatment of chronic donovanosis, and the acceptability to patients and staff of supervised outpatient treatment in rural clinics. " 04/01/1994 - "Ceftriaxone in the treatment of chronic donovanosis in central Australia." 04/01/1992 - "Failure of single dose ceftriaxone in donovanosis (granuloma inguinale)" 06/01/1991 - "Failure of single dose ceftriaxone in donovanosis (granuloma inguinale)"
7.	Cephalosporins (Cephalosporin Antibiotics)IBA 01/01/1987 - "The cephalosporins have no clear role in the treatment of syphilis, granuloma inguinale, Mycoplasma or chlamydial infections or bacterial vaginosis, but ceftriaxone may be effective in chancroid, and cefoxitin in combination with an antichlamydial agent (such as a tetracycline) might be used for the treatment of pelvic inflammatory disease."
8.	Cefoxitin (Cefoxitin Sodium)FDA LinkGeneric 01/01/1987 - "The cephalosporins have no clear role in the treatment of syphilis, granuloma inguinale, Mycoplasma or chlamydial infections or bacterial vaginosis, but ceftriaxone may be effective in chancroid, and cefoxitin in combination with an antichlamydial agent (such as a tetracycline) might be used for the treatment of pelvic inflammatory disease."
9.	Complement System Proteins (Complement)IBA 05/01/1950 - "Complement fixation studies in granuloma inguinale." 01/01/1953 - " II. The complement fixation test in the diagnosis of granuloma inguinale." 01/01/1945 - "6. The high proportion of precipitation and complement fixation reactions obtained from patients with active granuloma inguinale is indicative of a specific immunological relationship of the Donovan microorganism cultivated in embryonic yolk to the disease, granuloma inguinale. " 01/01/1945 - "Serum from 12 of 15 cases of granuloma inguinale demonstrated complement fixation. " 01/01/1945 - "5. The "capsular" material fixed complement in the presence of serum from patients with granuloma inguinale. "
10.	AntigensIBA 10/01/1991 - "HLA Class I, Class II and DQ antigens were detected in patients with genital ulceration caused by donovanosis and in a control group. " 01/01/1945 - "1. A washed bacterial suspension of Donovan microorganisms cultivated in the yolk of chick embryos was used as an antigen in intracutaneous tests in 6 cases of granuloma inguinale in the active stage of the disease. " 01/01/1945 - "6. The microorganism produces in culture antigens that elicit immune reactions in the skin and serum of granuloma inguinale patients. " 06/01/1947 - "Complement fixation studies with pus antigen in granuloma inguinale."

Therapies and Procedures

1.	Lymph Node Excision (Lymph Node Dissection) 01/01/2010 - "It may follow granuloma inguinale, carcinomas, lymph node dissection or irradiation and tuberculosis but this happens rarely. "
2.	Intramuscular Injections 07/01/1951 - "Intramuscular injections of chloromycetin in the treatment of granuloma inguinale."
3.	Hysterectomy 02/01/1998 - "The patient had no genital lesions at the time of diagnosis of extragenital donovanosis but had undergone a hysterectomy, thus raising the possibility of prior disease of the uterine cervix (most previous cases have been associated with primary cervical disease). "
4.	Curettage 06/01/1983 - "Granuloma inguinale of the cervix, labia majora, and anus developed after diagnostic endometrial curettage. "
5.	Amputation 09/01/2008 - "Donovanosis with auto-amputation of penis in a HIV-2 infected person." 09/01/2008 - "A final diagnosis of donovanosis with auto-amputation of penis with HIV-2 infection was made. "