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Gold Sodium Thiomalate (Sodium Aurothiomalate)

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A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.

Also Known As:

Sodium Aurothiomalate; Aurothiomalate; Altana Pharma Brand of Gold Sodium Thiomalate; Aurolate; Aventis Brand of Gold Sodium Thiomalate; Gold Disodium Thiomalate, Monohydrate; Gold Thiomalic Acid; JHC Brand of Gold Sodium Thiomalate; Mercaptobutanedioic Acid Monogold(1+) Sodium Salt; Merck Brand of Gold Sodium Thiomalate; Miocrin; Miocrisin; Monogold (1+) Disodium Thiomalate; Myochrysine; Myocrisin; Myocrysine; Rubio Brand of Gold Sodium Thiomalate; Sodium Thiomalatoaurate; Tauredon; Taylor Brand of Gold Sodium Thiomalate; Aurothiomalate, Sodium; Gold Thiomalate, Sodium; Sodium Thiomalate, Gold; Thiomalate, Gold; Thiomalatoaurate, Sodium; Gold Thiomalate; Sodium Gold Thiomalate; Butanedioic acid, mercapto-, monogold(1+) sodium salt

Networked: 341 relevant articles (18 outcomes, 45 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Fields, Alan P: 6 articles (06/2015 - 02/2006)
2.	Regala, Roderick P: 3 articles (10/2009 - 02/2006)
3.	Murray, Nicole R: 2 articles (06/2015 - 02/2006)
4.	Kean, W F: 2 articles (12/2012 - 06/2008)
5.	Belsky, Yu P: 2 articles (08/2012 - 06/2011)
6.	Danilets, M G: 2 articles (08/2012 - 06/2011)
7.	Ivanova, A N: 2 articles (08/2012 - 06/2011)
8.	Belska, N V: 2 articles (08/2012 - 06/2011)
9.	Leitges, Michael: 2 articles (04/2012 - 10/2009)
10.	Moilanen, Teemu: 2 articles (06/2010 - 06/2008)

Related Diseases

1.	Rheumatoid Arthritis 01/01/1988 - "In a prospective 24 week study of 25 patients with rheumatoid arthritis (RA) weekly intramuscular (IM) sodium aurothiomalate resulted in a small but significant reduction in the circulating lymphocyte count. " 12/01/1997 - "The good results of a therapy with small doses of sodium aurothiomalate (20 mg/month) in 17 patients suffering from rheumatoid arthritis are reported. " 09/01/1987 - "We examined the possibility that gold sodium thiomalate (GST), an effective treatment for rheumatoid arthritis, would inhibit gamma-IFN-mediated stimulation of monocyte/macrophages. " 11/01/1995 - "We report a study of 40 Caucasian patients with rheumatoid arthritis, treated with intramuscular sodium aurothiomalate, of whom 31 had chrysiasis. " 04/01/1984 - "During studies of the metabolism of disodium aurothiomalate in patients with rheumatoid arthritis we have found that its pharmaceutical preparation. "
2.	Exanthema (Rash) 01/01/1999 - "The aim of our study is to examine the possibility for the continuation of therapy after achieving clinical improvement in patients with skin rash and stomatitis as a result of treatment with ATM (Tauredon, "Byk Gulden", Germany)." 01/01/1984 - "There was a clear distinction concerning the nature of side effects: mucocutaneous symptoms, especially rash and pruritus, were approximately twice as common with Tauredon, whereas diarrhoea was much more frequent in patients treated with auranofin.(ABSTRACT TRUNCATED AT 250 WORDS)" 01/01/1984 - "With D-penicillamine treatment, the incidence of proteinuria rises during 6-12 months and then declines, but with aurothiomalate treatment the incidence of proteinuria and rash progressively decline. " 05/01/1988 - "A patient with seropositive, nodular rheumatoid arthritis (RA) developed contact allergy to gold jewellery following a severe skin rash which occurred after 13 weeks of treatment with sodium aurothiomalate. " 07/01/1992 - "Sixteen cases of either a pityriasiform or discoid eczematous rash occurring in patients with rheumatoid arthritis receiving treatment with gold (sodium aurothiomalate and auranofin) were studied. "
3.	Stomatitis 01/01/1999 - "The aim of our study is to examine the possibility for the continuation of therapy after achieving clinical improvement in patients with skin rash and stomatitis as a result of treatment with ATM (Tauredon, "Byk Gulden", Germany)." 03/01/1992 - "Skin rashes and stomatitis due to parenteral treatment of rheumatoid arthritis with sodium aurothiomalate." 06/01/2005 - "Nineteen patients (16%) reported an ADR taking aurothiomalate not previously experienced with aurothioglucose, the most frequently reported being pruritus, dermatitis/stomatitis, and chrysiasis/hyperpigmentation. " 03/01/1985 - "proteinuria, haematological abnormalities, stomatitis, diarrhoea and dermatitis) in rheumatoid arthritis (RA) to sodium aurothiomalate (gold) and to D-penicillamine (PA) were studied in 32 patients. "
4.	Inflammation 08/01/2012 - "Effect of NF-κB inhibitor aurothiomalate on local inflammation in experimental Th1- and Th2-type immune response." 06/01/2010 - "Aurothiomalate is a disease-modifying antirheumatic drug that suppresses inflammation and retards cartilage degradation and bone erosion in arthritis. " 08/01/2012 - "We compared the effect of NF-κB inhibitor aurothiomalate and voltaren on local inflammation in different types of immune response. " 08/01/1998 - "Therefore, aurothiomalate may attenuate inflammation by acting as a pro-drug which is reliant on neutrophils and monocytes to produce hypothiocyanite. " 01/01/1992 - "Effect of sodium aurothiomalate on carrageenan induced inflammation of the air pouch in mice."
5.	Synovitis 11/01/1988 - "Six patients received sodium aurothiomalate, up to 100 mg intramuscularly a week, and in these patients the early improvement in synovitis induced by methylprednisolone was maintained. " 08/01/1981 - "A mechanism of action of gold sodium thiomalate in diseases characterized by a proliferative synovitis: reversible changes in collagen production in cultured human synovial cells."

Related Drugs and Biologics

1.	Auranofin (Ridaura)
2.	Gold
3.	Methotrexate (Mexate)
4.	Azathioprine (Imuran)
5.	Penicillamine (Cuprimine)
6.	Sulfasalazine (Azulfidine)
7.	Gold Compounds
8.	Hydroxychloroquine (Plaquenil)
9.	Antigens
10.	Methylprednisolone

Related Therapies and Procedures

1.	Intramuscular Injections
2.	Heterologous Transplantation (Xenotransplantation)
3.	Drug Therapy (Chemotherapy)
4.	Injections
5.	Drug Repositioning