Glyoxal (Ethanedial)

08/15/1999 - "Impairment of alpha-oxoaldehyde detoxification is cytotoxic, and this may contribute to toxicity associated with GSH oxidation and S conjugation in oxidative stress and chemical toxicity, and to chronic pathogenesis associated with diabetes mellitus where there is oxidative stress and the formation of glyoxal, MG, and 3-DG is increased."
08/01/2010 - "These data attest to the presence of LDL-modifying agents differing from MDA (e.g., glyoxal and methylglyoxal) in the blood of diabetes mellitus patients. "
04/01/2008 - "Previous studies have demonstrated that reactive dicarbonyl compounds (e.g., methylglyoxal [MG] and glyoxal [GO]), formed as intermediate products of the Maillard reaction, irreversibly and progressively modify proteins over time and yield advanced glycation end products (AGEs), which are thought to contribute to the development of diabetes mellitus and its complications. "
12/01/2007 - "Previous studies have demonstrated that reactive dicarbonyl compounds [e.g., methylglyoxal (MGO) and glyoxal (GO)] irreversibly and progressively modify proteins over time and yield advanced glycation end products (AGEs), which are thought to contribute to the development of diabetes mellitus and its subsequent complications. "
08/05/2014 - "Immunogenicity of DNA-advanced glycation end product fashioned through glyoxal and arginine in the presence of Fe³⁺: its potential role in prompt recognition of diabetes mellitus auto-antibodies."

11/01/2007 - "We have now initiated studies on testing the hormetic effects of glyoxal and heat shock on the wound-healing capacity of skin fibroblasts and on the angiogenic ability of endothelial cells. "
01/12/2006 - "Room temperature and shock tube study of the reaction HCO+O2 using the photolysis of glyoxal as an efficient HCO source."
11/21/2008 - "The multi-channel thermal unimolecular decomposition of glyoxal was experimentally investigated in the temperature range 1106 K < T < 2320 K and at total densities of 1.7 x 10(-6) mol cm(-3) < rho < 1.9 x 10(-5) mol cm(-3) by monitoring HCO (frequency modulation spectroscopy, FMS), (CHO)(2) (UV absorption), and H atom (atom resonance absorption spectroscopy, H-ARAS) concentration-time profiles behind shock waves. "
07/16/2015 - "Additionally, new experiments on glyoxal pyrolysis and oxidation have been performed with glyoxal and glyoxal/oxygen mixtures in Ar behind shock waves at temperatures of 1285-1760 K at two different total density ranges. "
04/01/2008 - "Among these, the age-associated accumulation of advanced glycation end products (AGEs), such as N(epsilon)-(carboxymethyl)lysine (CML), has been demonstrated to be effectively prevented in glyoxal-exposed human skin fibroblasts following mild heat shock treatment. "

05/01/1999 - "In this study, effects of methyl-glyoxal bis(cyclopentylamidinohydrazone) (MGBCP), a potent inhibitor of the polyamine biosynthetic pathway, on the growth of human osteosarcoma HuO9 cells have been investigated. "
01/01/2004 - "In this study, we investigated the influence of collagen type I coating on the cytotoxic effect of glyoxal on rat calvarial osteoblastic cells and on human osteosarcoma cells (Saos-2) grown on titanium alloy, Ti6Al4V. "

02/01/2014 - "Here, we analyse the neuroprotective properties of the GLP-1 analogue liraglutide in human neuroblastoma cell line SH-SY5Y during methyl glyoxal stress. "
01/15/2005 - "In the present study, a human neuroblastoma cell line expressing the C-terminal 100 residues of APP (SH-SY5Y-SPA4CT) was used to determine the effect of proteasome inhibition, by lactacystin and Bz-LLL-COCHO (benzoyl-Leu-Leu-Leu-glyoxal), on APP processing at the gamma-secretase site. "

01/01/1983 - "Methyl-glyoxal bis guanyl hydrazone (methyl-GAG, MGBG) in lymphoma and Hodgkin's disease. "
07/01/1989 - "A phase II trial of combination chemotherapy with mitoxantrone, cisplatin, and methyl-glyoxal bix-guanylhydrazone (MGBG) was conducted in 32 patients with unfavorable histology malignant lymphoma. "