Renal Glycosuria

An autosomal inherited disorder due to defective reabsorption of GLUCOSE by the PROXIMAL RENAL TUBULES. The urinary loss of glucose can reach beyond 50 g/day. It is attributed to the mutations in the SODIUM-GLUCOSE TRANSPORTER 2 encoded by the SLC5A2 gene.

Also Known As:

Networked: 157 relevant articles (4 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Inborn Genetic Diseases (Disease, Hereditary)
2.	Type 2 Diabetes Mellitus (MODY)
3.	Hypercalciuria
4.	Glycosuria
5.	Glucose Intolerance

Experts

1.	Hou, Ping: 6 articles (01/2020 - 03/2011)
2.	Yu, Lei: 6 articles (01/2020 - 03/2011)
3.	Zhang, Hong: 6 articles (01/2020 - 03/2011)
4.	Liu, Guo-Ping: 3 articles (08/2016 - 11/2014)
5.	Lv, Ji-Cheng: 3 articles (01/2015 - 03/2011)
6.	Mount, David B: 2 articles (10/2022 - 12/2013)
7.	Gong, Siqian: 2 articles (03/2022 - 01/2017)
8.	Ji, Linong: 2 articles (03/2022 - 01/2017)
9.	Shao, Leping: 2 articles (03/2019 - 09/2016)
10.	Wang, Cui: 2 articles (03/2019 - 09/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Renal Glycosuria:

1.	Glucose (Dextrose)FDA LinkGeneric 01/01/1991 - "Glucose titration studies in his family revealed severe type A renal glucosuria in a younger brother, a mild type A defect in the mother and normal glucose reabsorption in the father; thus a spectrum of renal glucose transport defects was observed in members of the same family." 12/01/1980 - "Renal glucose titration studies were carried out in eight pregnant women with renal glucosuria and six female controls. " 10/01/1969 - "Renal glucose titration studies were carried out in 10 members of two pedigrees with familial renal glycosuria to test the accepted hypothesis of autosomal dominant inheritance and to investigate the genetic significance of "type A" and "type B" renal glycosuria. " 03/01/2022 - "During long-time follow up, the two patients had frequent unproportional renal glycosuria in the morning even when their fasting serum glucose was only slightly increased. " 01/01/2021 - "Physiologically, urine from the subject with normal kidney function does not contain detectable level of glucose unless otherwise renal glycosuria. "
2.	Sodium-Glucose Transporter 2 InhibitorsIBA 03/01/2022 - "Hereditary renal glycosuria, diabetes and responses to SGLT2 inhibitor." 01/01/2020 - "Tubuloglomerular Feedback in Renal Glucosuria: Mimicking Long-term SGLT-2 Inhibitor Therapy." 03/01/2022 - "To present the clinical features of two rare cases with hereditary renal glycosuria and diabetes, explore their responses to sodium-glucose cotransporter 2 (SGLT2) inhibitor, and summarize the reported solute carrier family 5 member 2 (SLC5A2) mutations and related phenotypes. " 07/01/2013 - "Genetic mutations in a SGLT2 isoform that results in benign renal glycosuria, as well as clinical studies with SGLT2 inhibitors in type 2 diabetes support the potential of this approach. " 07/01/2010 - "Genetic mutations in the kidney-specific SGLT2 isoform that result in benign renal glycosuria, as well as preclinical and clinical studies with SGLT2 inhibitors in type 2 diabetes, support the potential of this approach. "
3.	Sodium-Glucose Transport ProteinsIBA 01/01/2016 - "Genetic analysis revealed a separate, undescribed heterozygous mutation (c.265G>A; p.A89T) in the sodium/glucose cotransporter 2-encoding gene SGLT2 (also known as SLC5A2) in the family that segregated with the renal glucosuria phenotype. " 12/01/2002 - "Our data provide the first direct evidence of an etiologic role for the sodium/glucose cotransporter type 2 in the pathogenesis of renal glucosuria." 12/01/2002 - "Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)." 07/01/2012 - "Familial renal glucosuria (FRG) is an inherited renal tubular disorder characterized by persistent isolated glucosuria in the absence of hyperglycemia that is caused by mutations in the sodium-glucose cotransporter SGLT2 coding gene, SLC5A2. " 01/01/2010 - "[Sodium-glucose cotransporter type 2 inhibitors (SGLT2): from familial renal glucosuria to the treatment of type 2 diabetes mellitus]."
4.	Proteins (Proteins, Gene)FDA Link 08/09/1958 - "[Effect of lactoflavins on protein sensitivity in renal glycosuria]." 01/01/2020 - "A patient with renal glucosuria due to a congenital knock-out of the sodium-glucose cotransporter 2 (SGLT-2) protein because of a compound heterozygous mutation in the SLC5A2 gene may provide a natural model mimicking the effects of long-term SGLT-2 inhibitor therapy, which has been shown to exert kidney-protective effects beyond its antidiabetic properties. " 12/01/2013 - "DNA sequencing analysis of the SLC5A2 gene encoding the renal glucose transporter SGLT2 showed a homozygous frame-shift mutation (occurring after the glutamine at amino acid 168 and leading to premature termination of the protein at amino acid 186) diagnostic of familial renal glycosuria. "
5.	Hypoglycemic Agents (Hypoglycemics)IBA 08/01/1983 - "A male patient with recurring episodes of hypoglycemic attacks was diagnosed as having isolated ACTH deficiency as well as renal glycosuria and ichthyosis vulgaris. " 01/01/2020 - "A patient with renal glucosuria due to a congenital knock-out of the sodium-glucose cotransporter 2 (SGLT-2) protein because of a compound heterozygous mutation in the SLC5A2 gene may provide a natural model mimicking the effects of long-term SGLT-2 inhibitor therapy, which has been shown to exert kidney-protective effects beyond its antidiabetic properties. "
6.	Anti-Bacterial Agents (Antibiotics)IBA 12/01/2018 - "After antibiotic treatment, the UTI symptoms were relieved, but the renal glucosuria remained. "
7.	Protein Isoforms (Isoforms)IBA 07/01/2013 - "Genetic mutations in a SGLT2 isoform that results in benign renal glycosuria, as well as clinical studies with SGLT2 inhibitors in type 2 diabetes support the potential of this approach. " 07/01/2010 - "Genetic mutations in the kidney-specific SGLT2 isoform that result in benign renal glycosuria, as well as preclinical and clinical studies with SGLT2 inhibitors in type 2 diabetes, support the potential of this approach. "
8.	Amino AcidsFDA Link 05/01/2001 - "This case may represent a genetic defect unique from the abnormalities in previously described cases of primary renal glucosuria with different amino acid excretion patterns. " 12/01/1999 - "To distinguish between primary renal glucosuria and the Fanconi syndrome, measurement of the amino acid concentration in urine was performed." 03/20/1957 - "[True renal diabetes; glucose-amino acid diabetes (familial renal glycosuria and amino aciduria); 1st French report of a newly delineated syndrome; biological study]." 10/01/2014 - "Further, renal glucosuria, increased excretion of select amino acids, and abnormal fractional excretion of electrolytes were observed, indicating renal tubular dysfunction. " 11/01/2006 - "On referral, results of diagnostic tests indicated renal glucosuria, increased excretion of selected amino acids and abnormal fractional excretion of electrolytes consistent with renal tubular dysfunction. "
9.	Insulin (Novolin)FDA Link 11/01/1970 - "[Study of blood insulin in renal glycosuria]." 10/01/1976 - "[Determination of values of immunologically measurable insulin (IMI) in children with renal glycosuria]." 01/01/1967 - "[Renal glycosuria and blood insulin. " 07/01/1950 - "The effect of insulin on the death rate from diabetes mellitus, the diagnosis of diabetes mellitus, renal glycosuria and other innocent glycosurias." 01/01/2017 - "HOMA-IR and BMI were negatively associated with renal glycosuria after adjusting for age, sex, hypertension, and insulin therapy. "
10.	CalciumIBA 01/01/1987 - "Segmental sodium reabsorption in the proximal and distal tubule was evaluated by different methods in seven healthy subjects, seven patients with recurrent calcium nephrolithiasis, five patients with isolated renal glucosuria and three patients with Fanconi syndrome. " 11/01/1992 - "On the basis of studies that examined the site along the nephron responsible for hypercalciuria in rats with streptozocin-induced diabetes, we speculate that in children with renal glycosuria, there is defective reabsorption of glucose and calcium in the straight portion of the proximal tubule or in the collecting duct. "

Therapies and Procedures

1.	Therapeutics 11/01/1997 - "A diagnosis of renal glycosuria was made, oral hypoglycaemic therapy was stopped, patient improved and was discharged. " 12/01/1965 - "[Diagnosis, differential diagnosis and therapy of familial renal glycosuria]." 04/01/2011 - "We also discuss the physiology and pathophysiology of SGLTs, e.g., glucose galactose malabsorption and familial renal glycosuria, and briefly report on targeting of SGLTs for new therapies for diabetes." 05/24/2020 - "The girl has stable renal function and no residual nervous system damage in the next 1.5 years, but she underwent low dose prednisone therapy because of persistent renal glucosuria. " 01/01/2020 - "Tubuloglomerular Feedback in Renal Glucosuria: Mimicking Long-term SGLT-2 Inhibitor Therapy."
2.	Punctures 08/01/1976 - "Clearance and micropuncture studies were performed in 23 dogs without glucose loading to examine the tubule mechanism of renal glycosuria. " 08/01/1976 - "Micropuncture studies of glucose transport in the dog: mechanism of renal glycosuria."
3.	Drug Therapy (Chemotherapy) 08/01/1991 - "One (0.009%) had renal glycosuria, two (0.019%) were possibly NIDDY (MODY) and one (0.009%) had transient glycosuria while receiving anti-tuberculous chemotherapy. " 01/01/2022 - "We report about a patient who developed hyponatremia, hypokalemia with excessive urinary excretion of sodium and potassium, renal glycosuria, and aminoaciduria on the third day of the first cycle of cisplatin-containing chemotherapy."
4.	Transplantation 04/01/1984 - "The only difference observed between the two groups was the rate of decrease of plasma creatinine levels during the 1st week after transplantation: it was faster in the group without renal glycosuria. "
5.	Gastrectomy 01/01/1976 - "Fifty-eight patients with biochemical reactive hypoglycemia (blood glucose 45 mg% or less after a 100 g OGTT) were tested, of whom 11 subjects were obese with normal glucose tolerance, 9 were obese with chemical diabetes, 9 had chemical diabetes without obesity, 6 had undergone gastrectomy, 7 had renal glycosuria and 16 were apparently isolated. "