Renal Glycosuria

An autosomal inherited disorder due to defective reabsorption of GLUCOSE by the PROXIMAL RENAL TUBULES. The urinary loss of glucose can reach beyond 50 g/day. It is attributed to the mutations in the SODIUM-GLUCOSE TRANSPORTER 2 encoded by the SLC5A2 gene.

Also Known As:

Networked: 68 relevant articles (0 outcomes, 6 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Hypercalciuria
2.	Diabetes Mellitus
3.	Familial Hypophosphatemia (Phosphate Diabetes)
4.	Gestational Diabetes (Gestational Diabetes Mellitus)
5.	Proteinuria

Experts

1.	Wright, Ernest M: 2 articles (04/2011 - 02/2004)
2.	Okamoto, M M: 2 articles (11/2010 - 02/2008)
3.	Machado, U F: 2 articles (11/2010 - 02/2008)
4.	Freitas, H S: 2 articles (11/2010 - 02/2008)
5.	Prié, D: 1 article (12/2014)
6.	Duffield, Jeremy S: 1 article (12/2013)
7.	Zera, Chloe A: 1 article (12/2013)
8.	Pollak, Martin R: 1 article (12/2013)
9.	Mount, David B: 1 article (12/2013)
10.	Toka, Hakan R: 1 article (12/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Renal Glycosuria:

1.	Glucose (Dextrose)FDA LinkGeneric 08/01/1976 - "Clearance and micropuncture studies were performed in 23 dogs without glucose loading to examine the tubule mechanism of renal glycosuria. " 08/01/1976 - "Micropuncture studies of glucose transport in the dog: mechanism of renal glycosuria." 10/01/1969 - "Renal glucose titration studies were carried out in 10 members of two pedigrees with familial renal glycosuria to test the accepted hypothesis of autosomal dominant inheritance and to investigate the genetic significance of "type A" and "type B" renal glycosuria. " 03/20/1957 - "[True renal diabetes; glucose-amino acid diabetes (familial renal glycosuria and amino aciduria); 1st French report of a newly delineated syndrome; biological study]." 12/01/2014 - "Familial renal glycosuria and modifications of glucose renal excretion."
2.	Insulin (Novolin)FDA Link 11/01/1970 - "[Study of blood insulin in renal glycosuria]." 10/01/1976 - "[Determination of values of immunologically measurable insulin (IMI) in children with renal glycosuria]." 01/01/1967 - "[Renal glycosuria and blood insulin. " 07/01/1950 - "The effect of insulin on the death rate from diabetes mellitus, the diagnosis of diabetes mellitus, renal glycosuria and other innocent glycosurias." 01/01/1997 - "Abnormal blood glucose and insulin response during oral glucose tolerance test in familial renal glycosuria."
3.	Streptozocin (Streptozotocin)FDA Link 11/01/1992 - "On the basis of studies that examined the site along the nephron responsible for hypercalciuria in rats with streptozocin-induced diabetes, we speculate that in children with renal glycosuria, there is defective reabsorption of glucose and calcium in the straight portion of the proximal tubule or in the collecting duct. "
4.	Histidine (L-Histidine)FDA Link 01/01/1958 - "[Studies on the reabsorption of histidine in pregnancy, renal glycosuria and in patients with diminished kidney function]."
5.	CalciumIBA 11/01/1992 - "On the basis of studies that examined the site along the nephron responsible for hypercalciuria in rats with streptozocin-induced diabetes, we speculate that in children with renal glycosuria, there is defective reabsorption of glucose and calcium in the straight portion of the proximal tubule or in the collecting duct. "
6.	Galactose (Galactopyranose)FDA LinkGeneric 04/01/2011 - "We also discuss the physiology and pathophysiology of SGLTs, e.g., glucose galactose malabsorption and familial renal glycosuria, and briefly report on targeting of SGLTs for new therapies for diabetes." 01/01/1998 - "Defects in concentrative glucose transporters cause renal glycosuria and glucose-galactose malabsorption. " 01/01/1992 - "In epithelial cells lining the jejunum and proximal renal tubules, Na+/glucose cotransporters concentrate glucose inside cells using the transmembrane electrochemical potential of Na+. Molecular defects of different transporters of this class cause familial glucose-galactose malabsorption and renal glycosuria. " 09/01/1970 - "Glucose reabsorption in familial renal glycosuria and glucose-galactose malabsorption." 11/01/2010 - "It also considers congenital defects of sugar metabolism caused by aberrant expression of the SGLT1 in glucose-galactose malabsorption and the SGLT2 in familial renal glycosuria. "
7.	Blood Glucose (Blood Sugar)IBA 06/01/1993 - "High serum trehalase values were seen in diabetics with renal glycosuria at comparatively low levels of blood glucose. " 01/01/1984 - "Renal glycosuria is an inherited disorder of renal tubule function in which significant amounts of glucose are excreted in the urine in the simultaneous presence of normal blood glucose levels. " 08/01/2003 - "Her initial laboratory evaluation revealed hyponatremia (Na 117 mEq/L), polyuria (urine output >400 mL/h for several hours), renal glycosuria (blood glucose 120 mg/dL, urine glucose >1,000 mg/dL), and solute diuresis (urine osmolality 552 mOsm/kg H2O). " 01/01/1976 - "Fifty-eight patients with biochemical reactive hypoglycemia (blood glucose 45 mg% or less after a 100 g OGTT) were tested, of whom 11 subjects were obese with normal glucose tolerance, 9 were obese with chemical diabetes, 9 had chemical diabetes without obesity, 6 had undergone gastrectomy, 7 had renal glycosuria and 16 were apparently isolated. " 01/01/1997 - "Abnormal blood glucose and insulin response during oral glucose tolerance test in familial renal glycosuria."
8.	Uric Acid (Urate)IBA 08/01/2011 - "The patient also manifested hypouricaemia (serum uric acid 1.7 mg/dl [101 µmol/l]) with renal uric acid wasting and renal glycosuria. " 01/01/1991 - "A 59-year-old woman with kappa light-chain myeloma had Fanconi's syndrome characterized by renal glycosuria, generalized aminoaciduria, bicarbonaturia and decrease of phosphorus and uric acid reabsorption. " 11/01/2008 - "However, a variety of renal tubular abnormalities including hypercalciuria, hypo-magnesemia with renal magnesium wasting, decreased tubular absorption of phosphorus, hypo-uricemia with renal uric acid wasting, renal glycosuria and tubular proteinuria have been described even in patients with beta thalassemia minor. " 01/01/1992 - "Increased urinary amino acid nitrogen occurred in 8, raised fractional beta 2-microglobulin excretion in 2, hypophosphataemia in 4, renal glycosuria in 1 and enhanced fractional urate excretion in 1. Urinary N-acetyl-beta-glucosaminidase (NAG) excretion increased in 7; the mean urinary NAG/creatinine ratio was raised to twice the upper limit of the normal range. "
9.	SodiumIBA 07/25/1975 - "[Relation between glucose and sodium absorption in renal glycosuria (author's transl)]." 09/01/2013 - "[Sodium-glucose co-transporter-2 inhibitors: from the bark of apple trees and familial renal glycosuria to the treatment of type 2 diabetes mellitus]." 01/01/2005 - "Phlorizin's principal pharmacological action is to produce renal glycosuria and block intestinal glucose absorption through inhibition of the sodium-glucose symporters located in the proximal renal tubule and mucosa of the small intestine. " 08/01/1991 - "Glycine also attenuated the weight loss, polyuria, increased fractional excretion of sodium and potassium, decreased urinary osmolality, and renal glycosuria observed in control, saline-treated rats after cisplatin, while substantially decreasing the percentage of S3 tubules with evident morphological injury. "
10.	PhosphorusIBA 08/01/1947 - "Osteoporosis associated with low serum phosphorus and renal glycosuria." 07/01/1979 - "A case of osteomalacia associated with hypophosphatemia, decreased tubular reabsorption of phosphorus, hyperphosphaturia and renal glycosuria with associated bone pain and myopathy is presented. " 01/01/1991 - "A 59-year-old woman with kappa light-chain myeloma had Fanconi's syndrome characterized by renal glycosuria, generalized aminoaciduria, bicarbonaturia and decrease of phosphorus and uric acid reabsorption. " 11/01/2008 - "However, a variety of renal tubular abnormalities including hypercalciuria, hypo-magnesemia with renal magnesium wasting, decreased tubular absorption of phosphorus, hypo-uricemia with renal uric acid wasting, renal glycosuria and tubular proteinuria have been described even in patients with beta thalassemia minor. "

Therapies and Procedures

1.	Transplants (Transplant) 09/17/1984 - "Transient renal glycosuria was observed in eight renal transplant patients during the recovery phase from initial tubular necrosis or acute rejection. "
2.	Homologous Transplantation (Allograft) 09/17/1984 - "Renal glycosuria in renal homograft recipients."
3.	Transplantation (Transplant Recipients) 04/01/1984 - "The only difference observed between the two groups was the rate of decrease of plasma creatinine levels during the 1st week after transplantation: it was faster in the group without renal glycosuria. "
4.	Gastrectomy 01/01/1976 - "Fifty-eight patients with biochemical reactive hypoglycemia (blood glucose 45 mg% or less after a 100 g OGTT) were tested, of whom 11 subjects were obese with normal glucose tolerance, 9 were obese with chemical diabetes, 9 had chemical diabetes without obesity, 6 had undergone gastrectomy, 7 had renal glycosuria and 16 were apparently isolated. "
5.	Drug Therapy (Chemotherapy) 08/01/1991 - "One (0.009%) had renal glycosuria, two (0.019%) were possibly NIDDY (MODY) and one (0.009%) had transient glycosuria while receiving anti-tuberculous chemotherapy. "